PMID- 29978122
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220318
IS  - 2450-7393 (Print)
IS  - 2450-8608 (Electronic)
IS  - 2450-7393 (Linking)
VI  - 62
IP  - 1
DP  - 2018 Mar
TI  - Complete Genome Sequences of Three Sub-genotype 2.1b Isolates of Classical Swine 
      Fever Virus in China.
PG  - 7-15
LID - 10.2478/jvetres-2018-0002 [doi]
AB  - INTRODUCTION: Classical swine fever (CSF) has caused severe economic losses in 
      pig production in many countries. Recent CSF outbreaks in China are mainly 
      associated with sub-genotype 2.1 of CSF virus (CSFV). Although there is abundant 
      information regarding 2.1 isolates, few data are available on whole-genome 
      analysis. MATERIAL AND METHODS: The biological and genome characteristics of 
      three recently emerged Chinese CSFV isolates, i.e. SD2014-1, SD2014-2, and 
      SD2014-3, were fully analysed. RESULTS: Sequence analysis showed that the 
      isolates shared 83.4%-95.0% nucleotide identity with eight other CSFV isolates. 
      In addition, the 5' untranslated region (5'UTR) and the non-structural (NS) 
      proteins NS3, NS4A, and NS4B were more conserved than other regions of the 
      genome. Phylogenetic analysis based on the complete genome sequences or 
      full-length structural protein E2 gene sequences revealed that the three isolates 
      belonged to sub-genotype 2.1b. In addition, several unique molecular 
      characteristics of the 5'UTR, 3'UTR, and E2 were identified. CONCLUSION: The 
      genomic variations of the three isolates will support further analysis of 
      virulence determinants and the evolutionary trend of CSFV.
FAU - Liu, Chunxiao
AU  - Liu C
AD  - Henan Key Laboratory of Insect Biology in Funiu Mountain, Henan Provincial 
      Engineering Laboratory of Insects Bio-reactor, China-UK-NYNU-RRes Joint 
      Laboratory of Insect Biology, Nanyang Normal University, Nanyang, 473061, China.
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
FAU - Li, Mingliang
AU  - Li M
AD  - Henan Key Laboratory of Insect Biology in Funiu Mountain, Henan Provincial 
      Engineering Laboratory of Insects Bio-reactor, China-UK-NYNU-RRes Joint 
      Laboratory of Insect Biology, Nanyang Normal University, Nanyang, 473061, China.
FAU - Yin, Xingwang
AU  - Yin X
AD  - Henan Key Laboratory of Insect Biology in Funiu Mountain, Henan Provincial 
      Engineering Laboratory of Insects Bio-reactor, China-UK-NYNU-RRes Joint 
      Laboratory of Insect Biology, Nanyang Normal University, Nanyang, 473061, China.
FAU - Zhang, Hongliang
AU  - Zhang H
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
FAU - Xiang, Lirun
AU  - Xiang L
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
FAU - Zhai, Hongyue
AU  - Zhai H
AD  - Henan Key Laboratory of Insect Biology in Funiu Mountain, Henan Provincial 
      Engineering Laboratory of Insects Bio-reactor, China-UK-NYNU-RRes Joint 
      Laboratory of Insect Biology, Nanyang Normal University, Nanyang, 473061, China.
FAU - Wang, Congcong
AU  - Wang C
AD  - Henan Key Laboratory of Insect Biology in Funiu Mountain, Henan Provincial 
      Engineering Laboratory of Insects Bio-reactor, China-UK-NYNU-RRes Joint 
      Laboratory of Insect Biology, Nanyang Normal University, Nanyang, 473061, China.
FAU - Kan, Yunchao
AU  - Kan Y
AD  - Henan Key Laboratory of Insect Biology in Funiu Mountain, Henan Provincial 
      Engineering Laboratory of Insects Bio-reactor, China-UK-NYNU-RRes Joint 
      Laboratory of Insect Biology, Nanyang Normal University, Nanyang, 473061, China.
FAU - Yao, Lunguang
AU  - Yao L
AD  - Henan Key Laboratory of Insect Biology in Funiu Mountain, Henan Provincial 
      Engineering Laboratory of Insects Bio-reactor, China-UK-NYNU-RRes Joint 
      Laboratory of Insect Biology, Nanyang Normal University, Nanyang, 473061, China.
FAU - Tian, Zhijun
AU  - Tian Z
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
FAU - Leng, Chaoliang
AU  - Leng C
AD  - Henan Key Laboratory of Insect Biology in Funiu Mountain, Henan Provincial 
      Engineering Laboratory of Insects Bio-reactor, China-UK-NYNU-RRes Joint 
      Laboratory of Insect Biology, Nanyang Normal University, Nanyang, 473061, China.
LA  - eng
PT  - Journal Article
DEP - 20180330
PL  - Poland
TA  - J Vet Res
JT  - Journal of veterinary research
JID - 101696630
PMC - PMC5957456
OTO - NOTNLM
OT  - classical swine fever virus
OT  - complete genomic analysis
OT  - genomic variations
OT  - sub-genotype 2.1b
COIS- Conflict of Interests Statement: The authors declare that there is no conflict of 
      interests regarding the publication of this article.
EDAT- 2018/07/07 06:00
MHDA- 2018/07/07 06:01
PMCR- 2018/03/30
CRDT- 2018/07/07 06:00
PHST- 2017/10/22 00:00 [received]
PHST- 2018/03/15 00:00 [accepted]
PHST- 2018/07/07 06:00 [entrez]
PHST- 2018/07/07 06:00 [pubmed]
PHST- 2018/07/07 06:01 [medline]
PHST- 2018/03/30 00:00 [pmc-release]
AID - jvetres-2018-0002 [pii]
AID - 10.2478/jvetres-2018-0002 [doi]
PST - epublish
SO  - J Vet Res. 2018 Mar 30;62(1):7-15. doi: 10.2478/jvetres-2018-0002. eCollection 
      2018 Mar.