PMID- 29978132
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240426
IS  - 2450-7393 (Print)
IS  - 2450-8608 (Electronic)
IS  - 2450-7393 (Linking)
VI  - 62
IP  - 1
DP  - 2018 Mar
TI  - Toxicological Evaluation of Flumequine in Pubertal Male Rats After Oral 
      Administration for Six Weeks.
PG  - 87-96
LID - 10.1515/jvetres-2018-0012 [doi]
AB  - INTRODUCTION: Veterinarians use flumequine (FLU) widely but its toxicological 
      effects are still unclear. MATERIAL AND METHODS: FLU doses of 53, 200, or 750 
      mg/kg were administered orally for six weeks to pubertal male rats for evaluation 
      of their toxicity. RESULTS: Weight gain was poorer after seven days of exposure 
      to FLU 750, but relative weights of the brain, adrenal and thyroid glands, and 
      testes were notably higher. Haematological and lipid profile parameters, cardiac 
      markers, and inorganic phosphate significantly increased in the FLU 750 group. 
      Blood glucose, oestradiol and serum concentrations of immunoglobulins G (IgG) and 
      E (IgE) significantly decreased after treatment. The levels of interleukins 10 
      (IL-10) and 6 (IL-6) fell significantly in the FLU 200 and FLU 750 groups. 
      Cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) and 
      cyclooxygenase-2 (Cox-2) expression amplified after treatment. Serum levels of 
      free triiodothyronine (fT3) and free thyroxine (fT4) reduced in the FLU 200 and 
      FLU 750 groups without changes in total T3 or T4 level. All doses of FLU 
      significantly depressed concentrations of thyroid-stimulating hormone (TSH) and 
      testosterone. Histopathology of thyroid glands from rats treated with FLU 750 
      showed degeneration and depletion of thyroid follicular epithelial cells. 
      Expression of 8-hydroxydeoxyguanosine (8-OHdG) was increased in a dose-dependent 
      manner in the brain, but decreased in the testes. Expression of CYP1A1 increased 
      in the adrenal and pituitary glands. CONCLUSION: The results of this study 
      suggest that the toxicity of FLU in rats is an effect of its disruptive influence 
      on the pituitary-thyroid hormonal system and on the dysfunction of the immune 
      system.
FAU - Kang, JeongWoo
AU  - Kang J
AD  - Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, 177, 
      Hyeoksin 8-ro, Gimcheon-si, Gyeongsangbuk-do 39660, Republic of Korea.
FAU - Hossain, Md Akil
AU  - Hossain MA
AD  - Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, 177, 
      Hyeoksin 8-ro, Gimcheon-si, Gyeongsangbuk-do 39660, Republic of Korea.
FAU - Choi, Byungkook
AU  - Choi B
AD  - Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, 177, 
      Hyeoksin 8-ro, Gimcheon-si, Gyeongsangbuk-do 39660, Republic of Korea.
FAU - Cho, Joon-Hyoung
AU  - Cho JH
AD  - Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, 177, 
      Hyeoksin 8-ro, Gimcheon-si, Gyeongsangbuk-do 39660, Republic of Korea.
FAU - Kang, Seok-Jin
AU  - Kang SJ
AD  - Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, 177, 
      Hyeoksin 8-ro, Gimcheon-si, Gyeongsangbuk-do 39660, Republic of Korea.
FAU - Ku, Hyun-Ok
AU  - Ku HO
AD  - Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, 177, 
      Hyeoksin 8-ro, Gimcheon-si, Gyeongsangbuk-do 39660, Republic of Korea.
FAU - Jeong, Sang-Hee
AU  - Jeong SH
AD  - GLP Research Center, College of Natural Sciences, Hoseo University, 165, Asan 
      City, Republic of Korea.
FAU - Kang, Hwan-Goo
AU  - Kang HG
AD  - Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, 177, 
      Hyeoksin 8-ro, Gimcheon-si, Gyeongsangbuk-do 39660, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20180330
PL  - Poland
TA  - J Vet Res
JT  - Journal of veterinary research
JID - 101696630
PMC - PMC5957466
OTO - NOTNLM
OT  - flumequine
OT  - male rats
OT  - pituitary gland
OT  - thyroid gland
OT  - toxicity
COIS- Conflict of Interests Statement: The authors declare that there is no conflict of 
      interests regarding the publication of this article.
EDAT- 2018/07/07 06:00
MHDA- 2018/07/07 06:01
PMCR- 2018/03/30
CRDT- 2018/07/07 06:00
PHST- 2017/08/03 00:00 [received]
PHST- 2018/02/20 00:00 [accepted]
PHST- 2018/07/07 06:00 [entrez]
PHST- 2018/07/07 06:00 [pubmed]
PHST- 2018/07/07 06:01 [medline]
PHST- 2018/03/30 00:00 [pmc-release]
AID - jvetres-2018-0012 [pii]
AID - 10.1515/jvetres-2018-0012 [doi]
PST - epublish
SO  - J Vet Res. 2018 Mar 30;62(1):87-96. doi: 10.1515/jvetres-2018-0012. eCollection 
      2018 Mar.