PMID- 29978804 OWN - NLM STAT- MEDLINE DCOM- 20190215 LR - 20190215 IS - 1000-503X (Print) IS - 1000-503X (Linking) VI - 40 IP - 3 DP - 2018 Jun 28 TI - [Role of Paradoxical Hypersecretion of Glucagon in the Pathogenesis of Type 2 Diabetes Mellitus]. PG - 421-426 LID - 10.3881/j.issn.1000-503X.2018.03.022 [doi] AB - Insulin resistance and insulin deficiency have long been believed to be the two main causes of type 2 diabetes mellitus (T2DM). However,recent studies have shown that paradoxical hypersecretion of glucagon may also contribute the pathogenesis of T2DM. This article reviews the role of paradoxical hypersecretion of glucagon in the pathogenesis of T2DM and the recent advances in relevant treatment options. FAU - Nan, Min AU - Nan M AD - Department of Endocrinology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China. FAU - Li, Wen-Hui AU - Li WH AD - Department of Endocrinology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China. LA - chi PT - Journal Article PT - Review PL - China TA - Zhongguo Yi Xue Ke Xue Yuan Xue Bao JT - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae JID - 8006230 RN - 0 (Insulin) RN - 9007-92-5 (Glucagon) SB - IM MH - Diabetes Mellitus, Type 2/*physiopathology MH - Glucagon/*metabolism MH - Humans MH - Insulin MH - Insulin Resistance EDAT- 2018/07/07 06:00 MHDA- 2019/02/16 06:00 CRDT- 2018/07/07 06:00 PHST- 2018/07/07 06:00 [entrez] PHST- 2018/07/07 06:00 [pubmed] PHST- 2019/02/16 06:00 [medline] AID - 10.3881/j.issn.1000-503X.2018.03.022 [doi] PST - ppublish SO - Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2018 Jun 28;40(3):421-426. doi: 10.3881/j.issn.1000-503X.2018.03.022.