PMID- 29979416
OWN - NLM
STAT- MEDLINE
DCOM- 20180717
LR  - 20210109
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 27
DP  - 2018 Jul
TI  - Diagnostic value of quantitative coronary flow reserve and myocardial blood flow 
      estimated by dynamic 320 MDCT scanning in patients with obstructive coronary 
      artery disease.
PG  - e11354
LID - 10.1097/MD.0000000000011354 [doi]
LID - e11354
AB  - We have developed the method for dynamic 320-row multidetector computed 
      tomography (MDCT)-derived quantitative coronary flow reserve (CFRCT) and 
      hyperemic myocardial blood flow (MBFCT). We evaluated diagnostic value of CFRCT 
      and hyperemic MBFCT for detecting obstructive coronary artery disease (CAD) in 
      per-patient and per-vessel analysis, and their relations with the severity of CAD 
      burden.Adenosine stressed and rest dynamic myocardial perfusion MDCT were 
      prospectively performed in patients with known or suspected CAD. Per-patient and 
      per-vessel MBFCT were estimated from dynamic perfusion images in rest and 
      hyperemic phases, and per-patient and per-vessel CFRCT were calculated from the 
      ratio of rest and hyperemic MBFCT. Degree of stenosis was evaluated by coronary 
      CT angiography (CTA) and invasive coronary angiography (ICA). Obstructive 
      stenosis was defined as >/=70% stenosis in ICA. CAD burden with MDCT was calculated 
      by logarithm transformed coronary artery calcium (CAC) score and the CTA-adapted 
      Leaman risk score (CT-LeSc). A logistic regression analysis was used to measure 
      the receiver-operating characteristic curve and corresponding area under the 
      curve (AUC) for the detection of obstructive CAD.Twenty-seven patients and 81 
      vessels were eligible for this study. Sixteen patients had obstructive CAD, and 
      31 vessels had obstructive stenosis. Using an optimal cutoff, the CFRCT and 
      hyperemic MBFCT had the moderate diagnostic values in per-patient (AUC = 0.89 and 
      0.86, respectively) and per-vessel (AUC = 0.79 and 0.76, respectively). 
      Per-patient CFRCT and hyperemic MBFCT exhibited a moderate inverse correlation 
      with CAC score and the CT-LeSc.Per-patient and per-vessel CFRCT as well as 
      hyperemic MBFCT had moderate diagnostic value for detecting obstructive CAD. 
      These per-patient values exhibited a moderate inverse correlation with CAD 
      burden. CFRCT and hyperemic MBFCT might add quantitative functional information 
      for evaluating patients with CAD.
FAU - Obara, Masahiko
AU  - Obara M
AD  - Department of Cardiovascular Medicine, Hokkaido Chuo Rosai Hospital, Iwamizawa 
      Department of Cardiovascular Medicine, Hokkaido University Graduate School of 
      Medicine Department of Diagnostic and Interventional Radiology, Hokkaido 
      University Hospital Department of Nuclear Medicine, Hokkaido University Graduate 
      School of Medicine Department of Radiology, Hokkaido University Hospital Center 
      for Cause of Death Investigation, Hokkaido University Graduate School of Medicine 
      Faculty of Health Science, Hokkaido University Graduate School of Medicine, 
      Sapporo, Hokkaido Department of Radiology, Graduate School of Medical Science, 
      Kyoto Prefectural University of Medicine, Kyoto Department of Cardiovascular 
      Medicine, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
FAU - Naya, Masanao
AU  - Naya M
FAU - Oyama-Manabe, Noriko
AU  - Oyama-Manabe N
FAU - Aikawa, Tadao
AU  - Aikawa T
FAU - Tomiyama, Yuuki
AU  - Tomiyama Y
FAU - Sasaki, Tsukasa
AU  - Sasaki T
FAU - Kikuchi, Yasuka
AU  - Kikuchi Y
FAU - Manabe, Osamu
AU  - Manabe O
FAU - Katoh, Chietsugu
AU  - Katoh C
FAU - Tamaki, Nagara
AU  - Tamaki N
FAU - Tsutsui, Hiroyuki
AU  - Tsutsui H
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Aged
MH  - Area Under Curve
MH  - Computed Tomography Angiography/methods
MH  - Coronary Angiography/*methods
MH  - Coronary Artery Disease/*diagnostic imaging
MH  - Coronary Circulation
MH  - Coronary Vessels/diagnostic imaging
MH  - Female
MH  - Fractional Flow Reserve, Myocardial/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multidetector Computed Tomography/*methods
MH  - Myocardial Perfusion Imaging/*methods
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - ROC Curve
MH  - Regional Blood Flow
MH  - Sensitivity and Specificity
PMC - PMC6076151
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2018/07/07 06:00
MHDA- 2018/07/18 06:00
PMCR- 2018/07/06
CRDT- 2018/07/07 06:00
PHST- 2018/07/07 06:00 [entrez]
PHST- 2018/07/07 06:00 [pubmed]
PHST- 2018/07/18 06:00 [medline]
PHST- 2018/07/06 00:00 [pmc-release]
AID - 00005792-201807060-00043 [pii]
AID - MD-D-18-00319 [pii]
AID - 10.1097/MD.0000000000011354 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Jul;97(27):e11354. doi: 10.1097/MD.0000000000011354.