PMID- 29979503
OWN - NLM
STAT- MEDLINE
DCOM- 20180926
LR  - 20181004
IS  - 0513-4870 (Print)
IS  - 0513-4870 (Linking)
VI  - 52
IP  - 2
DP  - 2017 Feb
TI  - [Antidepressant activity of flavonoid ethanol extract of Abelmoschus manihot 
      corolla with BDNF up-regulation in the hippocampus].
PG  - 222-8
AB  - Abelmoschus manihot (L.) Medic., a folk herbal medicine in China, is a flowering 
      plant belonging to Abelmoschus L. genus and Malvaceae family, which has been 
      reported with an antidepressant activity. The study was designed to isolate 
      flavonoids from Abelmoschus manihot corolla and explore the action mechanism of 
      antidepressant activities. The flavonoids were isolated and purified by D101 
      macroporous resin column, polyamide column and Sephadex LH-20 sequentially and 
      identified as myricetin-3-O-beta-D-glucoside (1), gossypetin-8-O-beta-D-glucuronide (2, 
      G-8-G), gossypetin-3'-O-beta-D-glucoside (3), quercetin-3'-glucoside (4, Q-3-G), 
      isoquercitrin (5, IQT), hyperoside (6, HY), myricetin (7), quercetin (8, QT). 
      Compounds 2, 4, 5, 6 and 8 (15, 30 and 60 mg.kg-1) were orally administered to 
      mice and the reaction was observed in tail suspension test (TST) and forced 
      swimming test (FST). Western blot analysis was used in determination of the 
      protein expressions of brain-derived neurotrophic factor (BDNF), tyrosine 
      receptor kinase B (TrkB) and phosphorylation eukaryotic elongation factor 2 
      (p-eEF2). The results revealed that only Q-3-G and G-8-G (15, 30, 60 mg .kg-1) 
      significantly reduced the immobility time in FST and TST. Furthermore, Q-3-G and 
      G-8-G remarkably increased the expression of BDNF and TrkB, and decreased the 
      expression of p-eEF2. These results suggest that Q-3-G and G-8-G had an obvious 
      antidepressant activity via up-regulation of BDNF expression. The new observation 
      will provide a new direction in the development of antidepressant in the 
      treatment of major depressive disorder (MDD).
FAU - Cai, Hong-die
AU  - Cai HD
FAU - Tao, Wei-wei
AU  - Tao WW
FAU - Su, Shu-lan
AU  - Su SL
FAU - Guo, Sheng
AU  - Guo S
FAU - Zhu, Yue
AU  - Zhu Y
FAU - Guo, Jian-ming
AU  - Guo JM
FAU - Qian, Da-wei
AU  - Qian DW
FAU - Cong, Xu-dong
AU  - Cong XD
FAU - Tang, Ren-mao
AU  - Tang RM
FAU - Duan, Jin-ao
AU  - Duan JA
LA  - chi
PT  - Journal Article
PL  - China
TA  - Yao Xue Xue Bao
JT  - Yao xue xue bao = Acta pharmaceutica Sinica
JID - 21710340R
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Flavonoids)
RN  - 0 (Plant Extracts)
RN  - 0YX10VRV6J (isoquercitrin)
RN  - 3K9958V90M (Ethanol)
RN  - 76XC01FTOJ (myricetin)
RN  - 8O1CR18L82 (hyperoside)
RN  - 9IKM0I5T1E (Quercetin)
RN  - SET4M23ZTM (gossypetin)
SB  - IM
MH  - Abelmoschus/*chemistry
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - China
MH  - Depressive Disorder, Major
MH  - Drugs, Chinese Herbal/pharmacology
MH  - Ethanol
MH  - Flavonoids/*pharmacology
MH  - Hindlimb Suspension
MH  - Hippocampus/*drug effects/metabolism
MH  - Mice
MH  - Plant Extracts/*pharmacology
MH  - Quercetin/analogs & derivatives
MH  - Swimming
MH  - Up-Regulation
EDAT- 2017/02/01 00:00
MHDA- 2018/09/27 06:00
CRDT- 2018/07/07 06:00
PHST- 2018/07/07 06:00 [entrez]
PHST- 2017/02/01 00:00 [pubmed]
PHST- 2018/09/27 06:00 [medline]
PST - ppublish
SO  - Yao Xue Xue Bao. 2017 Feb;52(2):222-8.