PMID- 29979894
OWN - NLM
STAT- MEDLINE
DCOM- 20181218
LR  - 20181218
IS  - 1532-4311 (Electronic)
IS  - 0882-0139 (Linking)
VI  - 47
IP  - 7
DP  - 2018 Oct
TI  - Association between HLA class II alleles and hepatitis B virus infection in 
      Transylvania, Romania.
PG  - 735-744
LID - 10.1080/08820139.2018.1489832 [doi]
AB  - Infection with hepatitis B virus (HBV) is a major problem worldwide. The major 
      histocompatibility complex plays an essential role in host immunity and can help 
      eliminate the HBV of infected hepatocytes. Our study aimed to determine the role 
      of certain human leukocyte antigen (HLA) class II molecules (i.e. HLA-DRB1 and 
      HLA-DQB1) in the persistence or removal of HBV. Sixty patients confirmed to be 
      HBV-positive via real-time polymerase chain reaction (PCR), i.e. people with 
      chronic active hepatitis, were included in the study along with a control group 
      of 100 healthy individuals without evidence of HBV infection. The DNA was 
      subsequently used to determine HLA-DRB1 and HLA-DQB1 low-resolution typing 
      genetic profile via PCR amplification. The univariate analysis performed revealed 
      significant association of the HLA-DRB1*03 and HLA-DQB1*05 alleles to the 
      infected persons (study group), while HLA-DRB1*01 was shown to be protective 
      against HBV infection. To our knowledge, this is the first Romanian study 
      associating HLA with HBV, and it can provide valuable insight concerning the 
      relationship between genetic factors and immune response in the sampled 
      population.
FAU - Matei, Horea Vladi
AU  - Matei HV
AD  - a Department of Cell and Molecular Biology , 'Iuliu Hatieganu' University of 
      Medicine and Pharmacy , Cluj-Napoca , Romania.
AD  - b Molecular Biology Laboratory , Legal Medicine Institute , Cluj-Napoca , 
      Romania.
FAU - Vica, Mihaela Laura
AU  - Vica ML
AUID- ORCID: 0000-0003-0811-0821
AD  - a Department of Cell and Molecular Biology , 'Iuliu Hatieganu' University of 
      Medicine and Pharmacy , Cluj-Napoca , Romania.
FAU - Siserman, Costel Vasile
AU  - Siserman CV
AD  - b Molecular Biology Laboratory , Legal Medicine Institute , Cluj-Napoca , 
      Romania.
AD  - c Department of Legal Medicine , 'Iuliu Hatieganu' University of Medicine and 
      Pharmacy , Cluj-Napoca , Romania.
LA  - eng
PT  - Journal Article
DEP - 20180706
PL  - England
TA  - Immunol Invest
JT  - Immunological investigations
JID - 8504629
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - *Genotype
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Hepatitis B/*genetics
MH  - Hepatitis B virus/*immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Risk
MH  - Romania
MH  - Young Adult
OTO - NOTNLM
OT  - HBV
OT  - HLA-DQB1
OT  - HLA-DRB1
OT  - Transylvania region
EDAT- 2018/07/07 06:00
MHDA- 2018/12/19 06:00
CRDT- 2018/07/07 06:00
PHST- 2018/07/07 06:00 [pubmed]
PHST- 2018/12/19 06:00 [medline]
PHST- 2018/07/07 06:00 [entrez]
AID - 10.1080/08820139.2018.1489832 [doi]
PST - ppublish
SO  - Immunol Invest. 2018 Oct;47(7):735-744. doi: 10.1080/08820139.2018.1489832. Epub 
      2018 Jul 6.