PMID- 29980017
OWN - NLM
STAT- MEDLINE
DCOM- 20181115
LR  - 20181115
IS  - 1873-264X (Electronic)
IS  - 0731-7085 (Linking)
VI  - 159
DP  - 2018 Sep 10
TI  - Iron oxide/silica/polypyrrole nanocomposite sorbent for the comparison study of 
      direct-immersion and headspace solid-phase microextraction of aldehyde biomarkers 
      in human urine.
PG  - 37-44
LID - S0731-7085(18)30679-4 [pii]
LID - 10.1016/j.jpba.2018.06.052 [doi]
AB  - The short chain alkyl aldehydes, especially hexanal and heptanal, in urine are 
      considered as potential biomarkers of several diseases and their determination in 
      biological fluids has gained a great attention in recent years. Magnetic iron 
      oxide core-shell silica (Fe(3)O(4)/SiO(2)) nanoparticles was synthesized and 
      embedded in polypyrrole (PPy) during the in-situ electropolymerization on the 
      surface of a stainless-steel wire. The Fe(3)O(4)/SiO(2)/PPy coated steel wire was 
      used as a novel and effective solid-phase microextraction (SPME) fibre. It was 
      employed for the extraction and preconcentration of hexanal and heptanal through 
      direct-immersion (DI-) and headspace (HS-) SPME sampling strategies, followed by 
      GC-FID quantification. The prepared nanocomposite fiber was characterized by 
      scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy 
      (FT-IR). All influential variables on the extraction efficiency of the DI- and 
      HS-SPME sampling modes were studied and optimized. The calibration curves showed 
      acceptable linearity (R(2) > 0.99) over the range of 0.01-10 mug mL(-1) for the 
      DI-SPME-GC-FID and 0.01-15 mugmL(-1) for HS-SPME-GC-GID methods. The limit of 
      detections (LODs) corresponding to the analytes amounts for which signal-to-noise 
      ratios were equal to 3, estimated to be 0.1 and 0.5 ng mL(-1), for hexanal and 
      heptanal using HS-SPME-GC-FID, respectively. The LODs for DI-SPME-GC-FID method 
      were 0.1 and 1.0 for hexanal and heptanal. For six replicated analyses of 0.5 mug 
      mL(-1) of the analytes, the relative standard deviations (RSDs) were calculated 
      6.5-6.6% and 5.1-5.3%, for DI-SPME and HS-SPME, respectively. The two developed 
      methods were successfully applied for analysis of hexanal and heptanal in urine 
      samples without derivatization step. The HS-SPME-GC-FID sampling/determination 
      strategy showed better analytical figures of merit and longer lifetime for the 
      prepared nanocomposite fiber.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Ghiasvand, Alireza
AU  - Ghiasvand A
AD  - Department of Chemistry, Lorestan University, Khoramabad, Iran. Electronic 
      address: a_ghiasvand@yahoo.com.
FAU - Heidari, Nahid
AU  - Heidari N
AD  - Department of Chemistry, Lorestan University, Khoramabad, Iran.
FAU - Abdolhosseini, Sana
AU  - Abdolhosseini S
AD  - Department of Chemistry, Lorestan University, Khoramabad, Iran.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20180628
PL  - England
TA  - J Pharm Biomed Anal
JT  - Journal of pharmaceutical and biomedical analysis
JID - 8309336
RN  - 0 (Aldehydes)
RN  - 0 (Biomarkers)
RN  - 0 (Ferric Compounds)
RN  - 0 (Polymers)
RN  - 0 (Pyrroles)
RN  - 1K09F3G675 (ferric oxide)
RN  - 30604-81-0 (polypyrrole)
RN  - 7631-86-9 (Silicon Dioxide)
SB  - IM
MH  - Aldehydes/*urine
MH  - Biomarkers/urine
MH  - Ferric Compounds/*chemistry
MH  - Humans
MH  - Nanocomposites/*chemistry
MH  - Polymers/*chemistry
MH  - Pyrroles/*chemistry
MH  - Silicon Dioxide/*chemistry
MH  - Solid Phase Microextraction/*methods
OTO - NOTNLM
OT  - Direct immersion solid-phase microextraction
OT  - Diseases biomarker
OT  - Fe(3)O(4)/SiO(2)/PPY nanocomposite
OT  - Headspace solid-phase microextraction
OT  - Heptanal
OT  - Hexanal
EDAT- 2018/07/07 06:00
MHDA- 2018/11/16 06:00
CRDT- 2018/07/07 06:00
PHST- 2018/03/22 00:00 [received]
PHST- 2018/05/25 00:00 [revised]
PHST- 2018/06/25 00:00 [accepted]
PHST- 2018/07/07 06:00 [pubmed]
PHST- 2018/11/16 06:00 [medline]
PHST- 2018/07/07 06:00 [entrez]
AID - S0731-7085(18)30679-4 [pii]
AID - 10.1016/j.jpba.2018.06.052 [doi]
PST - ppublish
SO  - J Pharm Biomed Anal. 2018 Sep 10;159:37-44. doi: 10.1016/j.jpba.2018.06.052. Epub 
      2018 Jun 28.