PMID- 29980905
OWN - NLM
STAT- MEDLINE
DCOM- 20181214
LR  - 20230918
IS  - 1433-7339 (Electronic)
IS  - 0941-4355 (Linking)
VI  - 26
IP  - 12
DP  - 2018 Dec
TI  - Side effects of corticosteroids in patients with advanced cancer: a systematic 
      review.
PG  - 3979-3983
LID - 10.1007/s00520-018-4339-2 [doi]
AB  - PURPOSE: Corticosteroids are commonly used in palliative care settings, but are 
      associated with several side effects. Although adverse events (AEs) are highly 
      distressing for patients, few data are available from prospective studies to look 
      at incidence or predictors of such harms. The aim of this study is to identify AE 
      reporting among studies of patients with advanced cancer receiving 
      corticosteroids for any reason. METHODS: A systematic review was conducted using 
      the following data sources: PubMed, Medline, SCOPUS, Cochrane reviews, and 
      CINAHL. Randomized controlled trials (RCTs) with patients with advanced cancer 
      assessing the effect of corticosteroids were included. Consecutive cohort 
      observational studies of corticosteroid toxicities in cancer patients were also 
      included. RESULTS: Twenty-seven RCTs and 12 consecutive cohort observational 
      studies were identified. The most frequently reported primary outcome of RCTs was 
      nausea and vomiting (8/27). Dexamethasone was prescribed in almost half of RCTs 
      (13/27). In consecutive cohort studies, the primary outcomes were a wide variety 
      of symptoms. Dexamethasone was also the most common glucocorticoid used (7/12). 
      In terms of quality of AE reporting, two RCTs and one consecutive cohort study 
      used a validated AE assessment tool in their studies. CONCLUSIONS: Side effects 
      of corticosteroids in advanced cancer patients were poorly reported with few data 
      using validated tools. Researchers should be aware of the guideline of AE 
      reporting to provide the best evidence of risk-benefit balance. Developing 
      specific consensus guidelines about AE reporting in studies of glucocorticoids in 
      studies of people with advanced cancer would be useful.
FAU - Hatano, Yutaka
AU  - Hatano Y
AD  - Faculty of Medicine, Department of Psychosomatic Medicine, Kindai University, 
      Osaka, Japan.
FAU - Matsuoka, Hiromichi
AU  - Matsuoka H
AD  - Faculty of Medicine, Department of Psychosomatic Medicine, Kindai University, 
      Osaka, Japan.
AD  - IMPACCT, Faculty of Health, University of Technology Sydney, P O Box 123, Ultimo, 
      New South Wales, 2007, Australia.
FAU - Lam, Lawrence
AU  - Lam L
AD  - Tung Wah College, Homantin, Kowloon, Hong Kong.
AD  - Faculty of Health, University of Technology Sydney, Sydney, Australia.
FAU - Currow, David C
AU  - Currow DC
AD  - IMPACCT, Faculty of Health, University of Technology Sydney, P O Box 123, Ultimo, 
      New South Wales, 2007, Australia. david.currow@uts.edu.au.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20180706
PL  - Germany
TA  - Support Care Cancer
JT  - Supportive care in cancer : official journal of the Multinational Association of 
      Supportive Care in Cancer
JID - 9302957
RN  - 0 (Adrenal Cortex Hormones)
SB  - IM
MH  - Adrenal Cortex Hormones/*adverse effects/therapeutic use
MH  - Adult
MH  - Cohort Studies
MH  - Drug-Related Side Effects and Adverse Reactions/*etiology
MH  - Humans
MH  - Neoplasms/complications/*drug therapy
MH  - Prospective Studies
OTO - NOTNLM
OT  - Advanced cancer patients
OT  - Adverse event reporting
OT  - Corticosteroids
OT  - Palliative care
OT  - Systematic review
EDAT- 2018/07/08 06:00
MHDA- 2018/12/15 06:00
CRDT- 2018/07/08 06:00
PHST- 2018/01/09 00:00 [received]
PHST- 2018/06/28 00:00 [accepted]
PHST- 2018/07/08 06:00 [pubmed]
PHST- 2018/12/15 06:00 [medline]
PHST- 2018/07/08 06:00 [entrez]
AID - 10.1007/s00520-018-4339-2 [pii]
AID - 10.1007/s00520-018-4339-2 [doi]
PST - ppublish
SO  - Support Care Cancer. 2018 Dec;26(12):3979-3983. doi: 10.1007/s00520-018-4339-2. 
      Epub 2018 Jul 6.