PMID- 29981370 OWN - NLM STAT- MEDLINE DCOM- 20181120 LR - 20181120 IS - 1873-6351 (Electronic) IS - 0278-6915 (Linking) VI - 120 DP - 2018 Oct TI - Targeting ERK signaling pathway by polyphenols as novel therapeutic strategy for neurodegeneration. PG - 183-195 LID - S0278-6915(18)30448-4 [pii] LID - 10.1016/j.fct.2018.07.010 [doi] AB - Numerous chemicals, such as phenolic compounds are strong radical scavengers, capable of alleviating oxidative stress induced neurodegeneration. Dietary antioxidants, especially flavonoids, are being considered as a promising approach to prevent or slow the pathological development of neurological illness and aging. One of the major advantage of natural products is that of their anti-amyloid effects over synthetic counterpart, however a healthy diet provides these beneficial natural substances as nutraceuticals. The extracellular-signal-regulated kinase (ERK) is one of the main pharmacological target of natural phenolic compounds, participating in several therapeutic effects. Mounting evidence revealed that numerous bioflavonoids, obtained from a variety of dietary fruits or plants as well as medicinal herbal sources, exhibit protective or therapeutic functions versus development of neurodegenerative diseases mainly through modulation of different compartments of ERK signaling pathway. Currently, there is remarkable interest in the beneficial effects of natural flavonoids to improve neural performance and prevent the onset and development of major neurodegenerative diseases. Natural products originated from medicinal plants, in particular antioxidants, have gained a great deal of attention due to their safe and non-toxic natures. Here, we summarized the effect of natural bioflavonoids on ERK signaling pathway and their molecular mechanism. CI - Copyright (c) 2018 Elsevier Ltd. All rights reserved. FAU - Farzaei, Mohammad Hosein AU - Farzaei MH AD - Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: mh_farzaei@kums.ac.ir. FAU - Tewari, Devesh AU - Tewari D AD - Department of Pharmaceutical Sciences, Faculty of Technology, Bhimtal Campus, Kumaun University, Nainital, Uttarakhand, India. FAU - Momtaz, Saeideh AU - Momtaz S AD - Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran; Toxicology and Diseases Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences (TUMS), Tehran, Iran. FAU - Arguelles, Sandro AU - Arguelles S AD - Department of Physiology, Faculty of Pharmacy, University of Seville, Seville, Spain. FAU - Nabavi, Seyed Mohammad AU - Nabavi SM AD - Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: Nabavi208@gmail.com. LA - eng PT - Journal Article PT - Review DEP - 20180705 PL - England TA - Food Chem Toxicol JT - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JID - 8207483 RN - 0 (Polyphenols) RN - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases) SB - IM MH - Animals MH - Extracellular Signal-Regulated MAP Kinases/*drug effects/metabolism MH - Humans MH - Neurodegenerative Diseases/*drug therapy/pathology MH - Polyphenols/*pharmacology/therapeutic use/toxicity MH - Signal Transduction/*drug effects OTO - NOTNLM OT - ERK OT - Flavonoids OT - MAPK OT - MEK/ERK OT - Natural products OT - Neurodegenerative diseases EDAT- 2018/07/08 06:00 MHDA- 2018/11/21 06:00 CRDT- 2018/07/08 06:00 PHST- 2018/04/07 00:00 [received] PHST- 2018/06/23 00:00 [revised] PHST- 2018/07/04 00:00 [accepted] PHST- 2018/07/08 06:00 [pubmed] PHST- 2018/11/21 06:00 [medline] PHST- 2018/07/08 06:00 [entrez] AID - S0278-6915(18)30448-4 [pii] AID - 10.1016/j.fct.2018.07.010 [doi] PST - ppublish SO - Food Chem Toxicol. 2018 Oct;120:183-195. doi: 10.1016/j.fct.2018.07.010. Epub 2018 Jul 5.