PMID- 29981956
OWN - NLM
STAT- MEDLINE
DCOM- 20190822
LR  - 20190822
IS  - 1872-8952 (Electronic)
IS  - 1388-2457 (Linking)
VI  - 129
IP  - 9
DP  - 2018 Sep
TI  - Retinal ganglion cell function in recovered optic neuritis: Faster is not better.
PG  - 1813-1818
LID - S1388-2457(18)31124-6 [pii]
LID - 10.1016/j.clinph.2018.06.012 [doi]
AB  - OBJECTIVE: To assess residual retinal ganglion cell (RGC) function in patients 
      with recovered optic neuritis (ON) and multiple sclerosis (MS). METHODS: 
      Age-matched controls (C, n = 32) and MS patients (n = 17) with history of ON in 
      one eye but normal visual acuity and color vision were tested with steady-state 
      Pattern Electroretinogram (PERG). Light Emitting Diodes (LED)-generated bar 
      gratings, robust signal averaging and Fourier analysis were used to assess 
      response amplitude and latency. RESULTS: PERG amplitude was similar for C, ON and 
      fellow eyes (FE) (P = 0.4), but PERG latency was shortened in ON by 3.2 ms 
      (P = 0.002) and in FE by 2.0 ms (P = 0.02) and was correlated (P < 0.01) with 
      both Retinal Nerve Fiber Layer (RNFL) and Ganglion Cell Inner Plexiform Layer 
      (GCIPL) thicknesses. PERG latency shortening could be simulated in control 
      subjects (n = 8) by dioptrically blurring the edges of gratings (high spatial 
      frequencies), which reduced activity of parvocellular RGCs with smaller/slower 
      axons. The blurred PERG latency was shorter than baseline by 2.9 ms (P = 0.01). 
      CONCLUSIONS: PERG latency is shortened in both eyes of MS patients with recovered 
      unilateral ON, suggesting relative dysfunction of RGCs with slower axons and 
      sparing of RGCs with faster axons. SIGNIFICANCE: Assessment of PERG latency in MS 
      and ON may help identifying and monitoring RGC dysfunction. PERG latency 
      shortening in FE suggests primary retinopathy in MS.
CI  - Copyright (c) 2018 International Federation of Clinical Neurophysiology. Published 
      by Elsevier B.V. All rights reserved.
FAU - Monsalve, Pedro
AU  - Monsalve P
AD  - Bascom Palmer Eye Institute, University of Miami, FL, USA.
FAU - Ren, Sandy
AU  - Ren S
AD  - Bascom Palmer Eye Institute, University of Miami, FL, USA.
FAU - Jiang, Hong
AU  - Jiang H
AD  - Bascom Palmer Eye Institute, University of Miami, FL, USA.
FAU - Wang, Jianhua
AU  - Wang J
AD  - Bascom Palmer Eye Institute, University of Miami, FL, USA.
FAU - Kostic, Maja
AU  - Kostic M
AD  - Bascom Palmer Eye Institute, University of Miami, FL, USA.
FAU - Gordon, Philip
AU  - Gordon P
AD  - Bascom Palmer Eye Institute, University of Miami, FL, USA.
FAU - Porciatti, Vittorio
AU  - Porciatti V
AD  - Bascom Palmer Eye Institute, University of Miami, FL, USA. Electronic address: 
      vporciatti@med.miami.edu.
LA  - eng
GR  - P30 EY014801/NEI NIH HHS/National Eye Institute/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20180630
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
MH  - Adult
MH  - Electroretinography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*physiopathology
MH  - Optic Neuritis/*physiopathology
MH  - Recovery of Function/*physiology
MH  - Retina/*physiopathology
MH  - Retinal Ganglion Cells/*physiology
OTO - NOTNLM
OT  - Multiple sclerosis
OT  - Optic neuritis
OT  - Pattern electroretinogram
OT  - Retinal ganglion cells
EDAT- 2018/07/10 06:00
MHDA- 2019/08/23 06:00
CRDT- 2018/07/09 06:00
PHST- 2018/02/21 00:00 [received]
PHST- 2018/05/25 00:00 [revised]
PHST- 2018/06/13 00:00 [accepted]
PHST- 2018/07/10 06:00 [pubmed]
PHST- 2019/08/23 06:00 [medline]
PHST- 2018/07/09 06:00 [entrez]
AID - S1388-2457(18)31124-6 [pii]
AID - 10.1016/j.clinph.2018.06.012 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2018 Sep;129(9):1813-1818. doi: 10.1016/j.clinph.2018.06.012. 
      Epub 2018 Jun 30.