PMID- 29982741
OWN - NLM
STAT- MEDLINE
DCOM- 20190925
LR  - 20240313
IS  - 1096-0929 (Electronic)
IS  - 1096-6080 (Print)
IS  - 1096-0929 (Linking)
VI  - 165
IP  - 2
DP  - 2018 Oct 1
TI  - Developmental Exposure to Low Concentrations of Organophosphate Flame Retardants 
      Causes Life-Long Behavioral Alterations in Zebrafish.
PG  - 487-498
LID - 10.1093/toxsci/kfy173 [doi]
AB  - As the older class of brominated flame retardants (BFRs) are phased out of 
      commercial use because of findings of neurotoxicity with developmental exposure, 
      a newer class of flame retardants have been introduced, the organophosphate flame 
      retardants (OPFRs). Presently, little is known about the potential for 
      developmental neurotoxicity or the behavioral consequences of OPFR exposure. Our 
      aim was to characterize the life-long neurobehavioral effects of 4 widely used 
      OPFRs using the zebrafish model. Zebrafish embryos were exposed to 0.1% DMSO 
      (vehicle control); or one of the following treatments; isopropylated phenyl 
      phosphate (IPP) (0.01, 0.03, 0.1, 0.3 microM); butylphenyl diphenyl phosphate (BPDP) 
      (0.003, 0.03, 0.3, 3 microM); 2-ethylhexyl diphenyl phosphate (EHDP) (0.03, 0.3, 
      1 microM); isodecyl diphenyl phosphate (IDDP) (0.1, 0.3, 1, 10 microM) from 0- to 5-days 
      postfertilization. On Day 6, the larvae were tested for motility under 
      alternating dark and light conditions. Finally, at 5-7 months of age the exposed 
      fish and controls were tested on a battery of behavioral tests to assess 
      emotional function, sensorimotor response, social interaction and predator 
      evasion. These tests showed chemical-specific short-term effects of altered 
      motility in larvae in all of the tested compounds, and long-term impairment of 
      anxiety-related behavior in adults following IPP, BPDP, or EHDP exposures. Our 
      results show that OPFRs may not be a safe alternative to the phased-out BFRs and 
      may cause behavioral impacts throughout the lifespan. Further research should 
      evaluate the risk to mammalian experimental models and humans.
FAU - Glazer, Lilah
AU  - Glazer L
AD  - Department of Psychiatry and Behavioral Sciences, Duke University School of 
      Medicine, Durham, North Carolina 27710.
FAU - Hawkey, Andrew B
AU  - Hawkey AB
AD  - Department of Psychiatry and Behavioral Sciences, Duke University School of 
      Medicine, Durham, North Carolina 27710.
FAU - Wells, Corinne N
AU  - Wells CN
AD  - Department of Psychiatry and Behavioral Sciences, Duke University School of 
      Medicine, Durham, North Carolina 27710.
FAU - Drastal, Meghan
AU  - Drastal M
AD  - Department of Psychiatry and Behavioral Sciences, Duke University School of 
      Medicine, Durham, North Carolina 27710.
FAU - Odamah, Kathryn-Ann
AU  - Odamah KA
AD  - Department of Psychiatry and Behavioral Sciences, Duke University School of 
      Medicine, Durham, North Carolina 27710.
FAU - Behl, Mamta
AU  - Behl M
AD  - Toxicology Branch, National Toxicology Program Division, National Institute of 
      Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, 
      27709.
FAU - Levin, Edward D
AU  - Levin ED
AD  - Department of Psychiatry and Behavioral Sciences, Duke University School of 
      Medicine, Durham, North Carolina 27710.
LA  - eng
GR  - P42 ES010356/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
RN  - 0 (Flame Retardants)
RN  - 0 (Organophosphates)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Embryo, Nonmammalian/*drug effects/physiopathology
MH  - Embryonic Development/*drug effects
MH  - Flame Retardants/*toxicity
MH  - Larva/drug effects/growth & development
MH  - Motor Activity/drug effects
MH  - Organophosphates/*toxicity
MH  - *Zebrafish
PMC - PMC6154272
EDAT- 2018/07/10 06:00
MHDA- 2019/09/26 06:00
PMCR- 2018/06/29
CRDT- 2018/07/09 06:00
PHST- 2018/07/10 06:00 [pubmed]
PHST- 2019/09/26 06:00 [medline]
PHST- 2018/07/09 06:00 [entrez]
PHST- 2018/06/29 00:00 [pmc-release]
AID - 5046974 [pii]
AID - kfy173 [pii]
AID - 10.1093/toxsci/kfy173 [doi]
PST - ppublish
SO  - Toxicol Sci. 2018 Oct 1;165(2):487-498. doi: 10.1093/toxsci/kfy173.