PMID- 29982962
OWN - NLM
STAT- MEDLINE
DCOM- 20190109
LR  - 20190109
IS  - 1573-2576 (Electronic)
IS  - 0360-3997 (Linking)
VI  - 41
IP  - 5
DP  - 2018 Oct
TI  - Novel Anti-arthritic Mechanisms of Polydatin in Complete Freund's 
      Adjuvant-Induced Arthritis in Rats: Involvement of IL-6, STAT-3, IL-17, and 
      NF-small ka, CyrillicB.
PG  - 1974-1986
LID - 10.1007/s10753-018-0841-4 [doi]
AB  - Articular manifestations are the main hall mark for rheumatoid arthritis; 
      inflammation and oxidative stress are involved in its pathogenesis. This study 
      was designed to figure out the possible therapeutic potential of polydatin on 
      experimentally induced arthritis in rats. Polydatin (POLY) was administered 
      (200 mg/kg, p.o.) for 21 days to complete Freund's adjuvant (CFA; 0.1 ml, 
      s.c.)-induced arthritic rats. Meanwhile, methotrexate (MTX; 0.75 mg/kg, i.p.) was 
      given as a reference standard disease-modifying anti-rheumatic drug (DMARD). Both 
      POLY and MTX significantly attenuated articular damage associated with 
      CFA-induced arthritis. This was manifested by reducing levels of tumor necrosis 
      factor alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-17 (IL-17), and matrix 
      metalloproteinase-3 (MMP-3), paralleled with marked decrease in hind paw and 
      ankle diameters. Moreover, POLY and MTX downregulated gene expressions of 
      receptor activator of nuclear factor kappa-B ligand (RANKL) as well as signal 
      transducer and activator of transcription-3 (STAT3) besides hampering 
      immunohistochemical staining of vascular endothelial growth factor (VEGF) and 
      nuclear factor kappa-B (NF-kappaB). Furthermore, substantial decline in 
      myeloperoxidase (MPO) activity and malondialdehyde (MDA) level associated with 
      significant rise in reduced glutathione content (GSH) was observed. These 
      findings provide an innovative therapeutic approach of POLY as a natural 
      anti-arthritic drug through modulating IL-6/STAT-3/IL-17/NF-small ka, CyrillicB cascade. Graphical 
      Abstract ᅟ.
FAU - Kamel, Kamel M
AU  - Kamel KM
AUID- ORCID: 0000-0001-9488-617X
AD  - Pharmacology Department, National Organization for Drug Control and Research, 6 
      Abou Hazem St., Pyramids Ave., Giza, Egypt. doctorkamelmohamed@gmail.com.
FAU - Gad, Amany M
AU  - Gad AM
AD  - Pharmacology Department, National Organization for Drug Control and Research, 6 
      Abou Hazem St., Pyramids Ave., Giza, Egypt.
FAU - Mansour, Suzan M
AU  - Mansour SM
AD  - Pharmacology & Toxicology Department, Faculty of Pharmacy, Cairo University, Kasr 
      El-Aini St., Cairo, 11562, Egypt.
AD  - Pharmacology, Toxicology & Biochemistry Department, Faculty of Pharmaceutical 
      Sciences and Pharmaceutical Industries, Future University in Egypt, End of 90th 
      St., Fifth Settlement, New Cairo, Egypt.
FAU - Safar, Marwa M
AU  - Safar MM
AD  - Pharmacology & Toxicology Department, Faculty of Pharmacy, Cairo University, Kasr 
      El-Aini St., Cairo, 11562, Egypt.
AD  - Pharmacology & Biochemistry Department, Faculty of Pharmacy, The British 
      University in Egypt, Suez Desert Road, El Sherouk City, Cairo, 11837, Egypt.
FAU - Fawzy, Hala M
AU  - Fawzy HM
AD  - Pharmacology Department, National Organization for Drug Control and Research, 6 
      Abou Hazem St., Pyramids Ave., Giza, Egypt.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Inflammation
JT  - Inflammation
JID - 7600105
RN  - 0 (Glucosides)
RN  - 0 (Interleukin-17)
RN  - 0 (Interleukin-6)
RN  - 0 (NF-kappa B)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (Stat3 protein, rat)
RN  - 0 (Stilbenes)
RN  - 9007-81-2 (Freund's Adjuvant)
RN  - XM261C37CQ (polydatin)
SB  - IM
MH  - Animals
MH  - Arthritis, Experimental/chemically induced/*drug therapy
MH  - Freund's Adjuvant
MH  - Gene Expression Regulation/drug effects
MH  - Glucosides/*pharmacology/therapeutic use
MH  - Interleukin-17/metabolism
MH  - Interleukin-6/metabolism
MH  - NF-kappa B/metabolism
MH  - Rats
MH  - STAT3 Transcription Factor/metabolism
MH  - Stilbenes/*pharmacology/therapeutic use
OTO - NOTNLM
OT  - cytokines
OT  - methotrexate
OT  - pannus
OT  - polydatin
OT  - synovitis
EDAT- 2018/07/10 06:00
MHDA- 2019/01/10 06:00
CRDT- 2018/07/09 06:00
PHST- 2018/07/10 06:00 [pubmed]
PHST- 2019/01/10 06:00 [medline]
PHST- 2018/07/09 06:00 [entrez]
AID - 10.1007/s10753-018-0841-4 [pii]
AID - 10.1007/s10753-018-0841-4 [doi]
PST - ppublish
SO  - Inflammation. 2018 Oct;41(5):1974-1986. doi: 10.1007/s10753-018-0841-4.