PMID- 29983268
OWN - NLM
STAT- MEDLINE
DCOM- 20190520
LR  - 20190520
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 201
DP  - 2018 Nov
TI  - Striatal cerebral blood flow, executive functioning, and fronto-striatal 
      functional connectivity in clinical high risk for psychosis.
PG  - 231-236
LID - S0920-9964(18)30351-7 [pii]
LID - 10.1016/j.schres.2018.06.018 [doi]
AB  - BACKGROUND: Patients at clinical high risk (CHR) for psychosis exhibit increased 
      striatal cerebral blood flow (CBF) during the resting state and impaired 
      cognitive function. However, the relation between CBF and cognitive impairment is 
      unknown. We therefore studied the association between striatal CBF and executive 
      functioning and evaluated the functional connectivity (FC) between dorsal 
      striatum and the frontal cortex in CHR. METHODS: In total, 47 participants [29 
      with CHR, 18 matched clinical controls (CC)] were assessed for ultra-high-risk 
      criteria and basic symptoms and were tested for executive functioning using the 
      trail making test-B (TMT-B). Resting state mean CBF and FC were calculated from 
      arterial spin labeling 3T MRI data. RESULTS: Striatal CBF was highest in CHR 
      patients with TMT-B deficits and was significantly higher than that in CC with 
      and without TMT-B impairment. Further, a significantly lower CBF FC between the 
      dorsal striatum and the anterior cingulate cortex was revealed in CHR. 
      CONCLUSIONS: Our study suggests that higher striatal CBF might represent focal 
      pathology in CHR and is associated with disrupted cingulo-striatal FC and 
      executive dysfunctions.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Hubl, Daniela
AU  - Hubl D
AD  - Translational Research Center, University Hospital of Psychiatry, University of 
      Bern, Bern, Switzerland.
FAU - Schultze-Lutter, Frauke
AU  - Schultze-Lutter F
AD  - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, 
      University of Bern, Bern, Switzerland; Department of Psychiatry and 
      Psychotherapy, Medical Faculty, Heinrich-Heine-University, Dusseldorf, Germany.
FAU - Hauf, Martinus
AU  - Hauf M
AD  - Support Center for Advanced Neuroimaging (SCAN), Institute for Diagnostic and 
      Interventional Neuroradiology, University of Bern, Bern, Switzerland.
FAU - Dierks, Thomas
AU  - Dierks T
AD  - Translational Research Center, University Hospital of Psychiatry, University of 
      Bern, Bern, Switzerland.
FAU - Federspiel, Andrea
AU  - Federspiel A
AD  - Translational Research Center, University Hospital of Psychiatry, University of 
      Bern, Bern, Switzerland.
FAU - Kaess, Michael
AU  - Kaess M
AD  - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, 
      University of Bern, Bern, Switzerland.
FAU - Michel, Chantal
AU  - Michel C
AD  - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, 
      University of Bern, Bern, Switzerland.
FAU - Schimmelmann, Benno G
AU  - Schimmelmann BG
AD  - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, 
      University of Bern, Bern, Switzerland; University Hospital of Child and 
      Adolescent Psychiatry, University Hospital Hamburg Eppendorf, Hamburg, Germany.
FAU - Kindler, Jochen
AU  - Kindler J
AD  - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, 
      University of Bern, Bern, Switzerland. Electronic address: 
      jochen.kindler@kjp.unibe.ch.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180706
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Brain Mapping
MH  - Cerebrovascular Circulation
MH  - Cognition/physiology
MH  - Cognitive Dysfunction/diagnostic imaging/etiology/physiopathology
MH  - Corpus Striatum/diagnostic imaging/*physiopathology
MH  - Cross-Sectional Studies
MH  - Executive Function/*physiology
MH  - Female
MH  - Frontal Lobe/diagnostic imaging/*physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neural Pathways/diagnostic imaging/physiopathology
MH  - Prodromal Symptoms
MH  - Psychotic Disorders/diagnostic imaging/drug therapy/*physiopathology/psychology
MH  - *Regional Blood Flow
MH  - Rest
MH  - Risk
MH  - Young Adult
OTO - NOTNLM
OT  - Anterior cingulate cortex
OT  - Arterial spin labeling
OT  - Cerebral blood flow
OT  - Cognition
OT  - Connectivity
OT  - Psychosis risk
OT  - Striatum
EDAT- 2018/07/10 06:00
MHDA- 2019/05/21 06:00
CRDT- 2018/07/10 06:00
PHST- 2017/09/12 00:00 [received]
PHST- 2018/01/22 00:00 [revised]
PHST- 2018/06/09 00:00 [accepted]
PHST- 2018/07/10 06:00 [pubmed]
PHST- 2019/05/21 06:00 [medline]
PHST- 2018/07/10 06:00 [entrez]
AID - S0920-9964(18)30351-7 [pii]
AID - 10.1016/j.schres.2018.06.018 [doi]
PST - ppublish
SO  - Schizophr Res. 2018 Nov;201:231-236. doi: 10.1016/j.schres.2018.06.018. Epub 2018 
      Jul 6.