PMID- 29983798
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1857-9655 (Print)
IS  - 1857-9655 (Electronic)
IS  - 1857-9655 (Linking)
VI  - 6
IP  - 6
DP  - 2018 Jun 20
TI  - Proton Pump Inhibitors Diminish Barrett's Esophagus Length: Our Experience.
PG  - 1041-1045
LID - 10.3889/oamjms.2018.232 [doi]
AB  - AIM: Our main objectives were to evaluate the influence of two-year proton pump 
      inhibitors (PPI) therapy in patients with Barrett's oesophagus on its length, in 
      both types, short and long segment. METHODS: In this single-centre, prospective 
      interventional controlled study were analysed data collected prospectively over 
      two years from patients with Barrett's oesophagus diagnosed by endoscopy. 
      Patients who received continuous proton pump inhibitors (PPI) for 2 years were 
      included. At each patient visit symptoms were recorded, and at each endoscopy, 
      the length of Barrett's oesophagus (BE) was measured. Biopsies were taken along 
      the length of the oesophagus at intervals of 1 cm. In total, 50 patients with 
      Barrett's oesophagus were included in the study: 10 of whom had long-segment 
      Barrett's oesophagus, and 40 patients had short-segment Barrett's oesophagus. The 
      mean number of endoscopies performed was 3 per patient. RESULTS: The length of 
      Barrett's esophagus (BE) was influenced by PPI therapy: Circumferential extension 
      in BE patients short-segment Barrett's esophagus (SSBE) (before treatment was 1.5 
      cm and after treatment was 0.8 cm Maximum proximal extension in SSBE group before 
      treatment was 2.3 cm (SD +/- 1.1 cm), and 1.1 cm (SD +/- 0.9 cm), respectively. 
      Squamous islands were detected in 25% of patients examined after 2 years on PPIs. 
      CONCLUSIONS: PPIs achieve a reduction to the length of Barrett's oesophagus, in 
      both types, and the development of squamous islands is commonly associated with 
      their use.
FAU - Gashi, Zaim
AU  - Gashi Z
AD  - University Clinical Center, Clinic of Gastroenterology, Prishtina, Kosovo.
FAU - Bahtiri, Elton
AU  - Bahtiri E
AD  - University Clinical Center, Institute of Pharmacology, Prishtina, Kosovo.
FAU - Gashi, Arjeta
AU  - Gashi A
AD  - University Clinical Center, Institute of Pharmacology, Prishtina, Kosovo.
FAU - Sherifi, Fadil
AU  - Sherifi F
AD  - University Clinical Center, Clinic of Gastroenterology, Prishtina, Kosovo.
LA  - eng
PT  - Journal Article
DEP - 20180608
PL  - North Macedonia
TA  - Open Access Maced J Med Sci
JT  - Open access Macedonian journal of medical sciences
JID - 101662294
PMC - PMC6026409
OTO - NOTNLM
OT  - Barrett's oesophagus
OT  - Endoscopy
OT  - Proton pump inhibitor
OT  - Squamous islands
EDAT- 2018/07/10 06:00
MHDA- 2018/07/10 06:01
PMCR- 2018/06/08
CRDT- 2018/07/10 06:00
PHST- 2018/03/21 00:00 [received]
PHST- 2018/05/04 00:00 [revised]
PHST- 2018/05/19 00:00 [accepted]
PHST- 2018/07/10 06:00 [entrez]
PHST- 2018/07/10 06:00 [pubmed]
PHST- 2018/07/10 06:01 [medline]
PHST- 2018/06/08 00:00 [pmc-release]
AID - OAMJMS-6-1041 [pii]
AID - 10.3889/oamjms.2018.232 [doi]
PST - epublish
SO  - Open Access Maced J Med Sci. 2018 Jun 8;6(6):1041-1045. doi: 
      10.3889/oamjms.2018.232. eCollection 2018 Jun 20.