PMID- 29984565
OWN - NLM
STAT- MEDLINE
DCOM- 20190621
LR  - 20190621
IS  - 1973-9095 (Electronic)
IS  - 1973-9087 (Linking)
VI  - 55
IP  - 1
DP  - 2019 Feb
TI  - Combined aerobic exercise and high-intensity respiratory muscle training in 
      patients surgically treated for non-small cell lung cancer: a pilot randomized 
      clinical trial.
PG  - 113-122
LID - 10.23736/S1973-9087.18.05156-0 [doi]
AB  - BACKGROUND: Lung resection surgery further decreases exercise capacity and 
      negatively affects respiratory muscle function in patients with non-small cell 
      lung cancer (NSCLC). The best design for exercise interventions in these patients 
      has not been determined yet. AIM: To assess the impact of aerobic exercise and 
      high-intensity respiratory muscle training on patient outcomes following lung 
      cancer resection surgery. DESIGN: Prospective, single-blind, pilot randomized 
      controlled trial. SETTING: Outpatient cardiopulmonary rehabilitation unit of two 
      university hospitals. POPULATION: Thirty-seven patients with NSCLC after tumor 
      resection. METHODS: Patients were randomly assigned to exercise training or usual 
      post-operative care. The training program consisted of aerobic exercises and 
      high-intensity respiratory muscle training (24 supervised sessions, 3 per week, 8 
      weeks). Primary outcome was exercise capacity assessed with peak oxygen uptake 
      (VO2peak) during cardiopulmonary exercise test. Secondary outcomes included 
      changes in respiratory muscle strength, levels of serum insulin growth factor I 
      (IGF-I) and IGF binding protein 3 (IGFBP-3), and quality of life assessed with 
      the European Organization for Research and Treatment of Cancer (EORTC QLQ-C30) 
      questionnaire. RESULTS: The 8-week training program was associated with 
      significant improvement in VO2peak (2.13 mL/Kg/min [95%CI 0.06 to 4.20]), maximal 
      inspiratory and expiratory pressures (18.96 cmH2O [95% CI 2.7 to 24.1] and 18.58 
      cmH2O [95% CI 4.0 to 33.1], respectively) and IGFBP-3 (0.61 microg/mL [%95 CI 0.1 to 
      1.12]). No significant differences were observed in the EORTC QLQ-C30. 
      CONCLUSIONS: An 8-week exercise program consisting of aerobic exercise and 
      high-intensity respiratory muscle training improved exercise capacity, 
      respiratory muscle strength, and serum IGFBP-3 levels in NSCLC patients after 
      lung resection. There was no impact on the other outcomes assessed. CLINICAL 
      REHABILITATION IMPACT: A combination of aerobic exercise and respiratory muscle 
      training could be included in the rehabilitation program of deconditioned 
      patients with NSCLC after lung resection surgery.
FAU - Messaggi-Sartor, Monique
AU  - Messaggi-Sartor M
AD  - Rehabilitation Research Group, Institut Hospital del Mar d'Investigacions 
      Mediques (IMIM), Barcelona, Spain.
AD  - Department of Physical Medicine and Rehabilitation, Parc de Salut Mar, Hospital 
      del Mar, Hospital de l'Esperanca, Barcelona, Spain.
FAU - Marco, Ester
AU  - Marco E
AD  - Rehabilitation Research Group, Institut Hospital del Mar d'Investigacions 
      Mediques (IMIM), Barcelona, Spain - emarco@parcdesalutmar.cat.
AD  - Department of Physical Medicine and Rehabilitation, Parc de Salut Mar, Hospital 
      del Mar, Hospital de l'Esperanca, Barcelona, Spain.
AD  - School of Medicine, Autonomous University of Barcelona, Barcelona, Spain.
FAU - Martinez-Tellez, Elisabeth
AU  - Martinez-Tellez E
AD  - Department of Thoracic Surgery, Hospital de la Santa Creu i Sant Pau, Barcelona, 
      Spain.
FAU - Rodriguez-Fuster, Alberto
AU  - Rodriguez-Fuster A
AD  - Department of Thoracic Surgery, Hospital del Mar, Barcelona, Spain.
FAU - Palomares, Carolina
AU  - Palomares C
AD  - Unit of Pulmonary Rehabilitation, Department of Respiratory Medicine, Hospital de 
      la Santa Creu i Sant Pau, Barcelona, Spain.
FAU - Chiarella, Sandra
AU  - Chiarella S
AD  - Department of Physical Medicine and Rehabilitation, Parc de Salut Mar, Hospital 
      del Mar, Hospital de l'Esperanca, Barcelona, Spain.
FAU - Muniesa, Josep M
AU  - Muniesa JM
AD  - Rehabilitation Research Group, Institut Hospital del Mar d'Investigacions 
      Mediques (IMIM), Barcelona, Spain.
AD  - Department of Physical Medicine and Rehabilitation, Parc de Salut Mar, Hospital 
      del Mar, Hospital de l'Esperanca, Barcelona, Spain.
FAU - Orozco-Levi, Mauricio
AU  - Orozco-Levi M
AD  - Department of Respiratory Medicine, Hospital del Mar, Barcelona, Spain.
AD  - Department of Health and Experimental Sciences (CEXS), Universitat Pompeu i Fabra 
      (UPF), Parc de Recerca Biomedica de Barcelona (PRBB), Barcelona, Spain.
FAU - Barreiro, Esther
AU  - Barreiro E
AD  - Department of Health and Experimental Sciences (CEXS), Universitat Pompeu i Fabra 
      (UPF), Parc de Recerca Biomedica de Barcelona (PRBB), Barcelona, Spain.
AD  - Department of Pulmonology, Lung Cancer and Muscle Research Group, IMIM, Hospital 
      del Mar, Barcelona, Spain.
AD  - Centro de Investigacion en Red de Enfermedades Respiratorias (CIBERES), Instituto 
      de Salud Carlos III (ISCIII), Madrid, Spain.
FAU - Guell, Maria R
AU  - Guell MR
AD  - Unit of Pulmonary Rehabilitation, Department of Respiratory Medicine, Hospital de 
      la Santa Creu i Sant Pau, Barcelona, Spain.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20180706
PL  - Italy
TA  - Eur J Phys Rehabil Med
JT  - European journal of physical and rehabilitation medicine
JID - 101465662
RN  - 0 (IGFBP3 protein, human)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Aged
MH  - *Breathing Exercises
MH  - Carcinoma, Non-Small-Cell Lung/physiopathology/*rehabilitation/*surgery
MH  - Exercise
MH  - *Exercise Therapy
MH  - Exercise Tolerance
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/blood
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Lung Neoplasms/physiopathology/*rehabilitation/*surgery
MH  - Male
MH  - Middle Aged
MH  - Muscle Strength
MH  - Pilot Projects
MH  - Pneumonectomy
MH  - Prospective Studies
MH  - Quality of Life
MH  - Single-Blind Method
EDAT- 2018/07/10 06:00
MHDA- 2019/06/22 06:00
CRDT- 2018/07/10 06:00
PHST- 2018/07/10 06:00 [pubmed]
PHST- 2019/06/22 06:00 [medline]
PHST- 2018/07/10 06:00 [entrez]
AID - S1973-9087.18.05156-0 [pii]
AID - 10.23736/S1973-9087.18.05156-0 [doi]
PST - ppublish
SO  - Eur J Phys Rehabil Med. 2019 Feb;55(1):113-122. doi: 
      10.23736/S1973-9087.18.05156-0. Epub 2018 Jul 6.