PMID- 29984631
OWN - NLM
STAT- MEDLINE
DCOM- 20190227
LR  - 20190227
IS  - 1744-828X (Electronic)
IS  - 1741-0541 (Linking)
VI  - 15
IP  - 4
DP  - 2018 Jul 1
TI  - Zinc finger and interferon-stimulated genes play a vital role in TB-IRIS 
      following HAART in AIDS.
PG  - 251-269
LID - 10.2217/pme-2017-0084 [doi]
AB  - AIM: Co-infection in HIV-1 patients with Mycobacterium tuberculosis poses 
      considerable risk of developing the immune reconstitution inflammatory syndrome 
      (IRIS), especially upon the initiation of antiretroviral therapy (ART). 
      Methodology & results: For transcriptomic analysis, peripheral blood mononuclear 
      cells' whole gene expression was used from three patient groups: HIV(+) (H), 
      HIV-TB(+) (HT), HIV-TB(+) with IRIS (HTI). Pathway enrichment and functional 
      analysis was performed before and after highly active ART. Genes in the 
      interferon-stimulating and ZNF families maintained tight functional interaction 
      and tilted the balance in favor of TB-IRIS. DISCUSSION & CONCLUSION: The 
      functional impairment of interaction between ZNF genes and interferon-stimulated 
      genes, along with higher expression of S100A8/S100A9 genes possibly forms the 
      genomic basis of TB-IRIS in a subset of HIV patients while on highly active ART.
FAU - Ma, Jinmin
AU  - Ma J
AD  - BGI-Shenzhen, Shenzhen 518083, PR China.
AD  - Laboratory of Genomics and Molecular Biomedicine, Department of Biology, 
      University of Copenhagen, Copenhagen 2100, Denmark.
AD  - China National GeneBank, BGI-Shenzhen, Shenzhen 518120, PR China.
FAU - Zhao, Fang
AU  - Zhao F
AD  - Shenzhen Third People's Hospital, Shenzhen 518112, PR China.
FAU - Su, Wei
AU  - Su W
AD  - BGI-Shenzhen, Shenzhen 518083, PR China.
FAU - Li, Qiongfang
AU  - Li Q
AD  - BGI-Shenzhen, Shenzhen 518083, PR China.
AD  - China National GeneBank, BGI-Shenzhen, Shenzhen 518120, PR China.
FAU - Li, Jiandong
AU  - Li J
AD  - BGI-Shenzhen, Shenzhen 518083, PR China.
AD  - China National GeneBank, BGI-Shenzhen, Shenzhen 518120, PR China.
FAU - Ji, Jingkai
AU  - Ji J
AD  - BGI-Shenzhen, Shenzhen 518083, PR China.
AD  - China National GeneBank, BGI-Shenzhen, Shenzhen 518120, PR China.
FAU - Deng, Yong
AU  - Deng Y
AD  - Shenzhen Third People's Hospital, Shenzhen 518112, PR China.
FAU - Zhou, Yang
AU  - Zhou Y
AD  - Shenzhen Third People's Hospital, Shenzhen 518112, PR China.
FAU - Wang, Xinfa
AU  - Wang X
AD  - Shenzhen Third People's Hospital, Shenzhen 518112, PR China.
FAU - Yang, Huanming
AU  - Yang H
AD  - BGI-Shenzhen, Shenzhen 518083, PR China.
AD  - James D. Watson Institute of Genome Science, Hangzhou 310007, PR China.
FAU - Saksena, Nitin K
AU  - Saksena NK
AD  - BGI-Shenzhen, Shenzhen 518083, PR China.
AD  - IGO, 19a Boundary Street, Rushcutters Bay, Sydney, NSW, Australia.
FAU - Kristiansen, Karsten
AU  - Kristiansen K
AD  - Laboratory of Genomics and Molecular Biomedicine, Department of Biology, 
      University of Copenhagen, Copenhagen 2100, Denmark.
FAU - Wang, Hui
AU  - Wang H
AD  - BGI-Shenzhen, Shenzhen 518083, PR China.
AD  - Department of Engineering Science, University of Oxford, Oxford OX3 7DQ, UK.
FAU - Liu, Yingxia
AU  - Liu Y
AD  - Shenzhen Third People's Hospital, Shenzhen 518112, PR China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180709
PL  - England
TA  - Per Med
JT  - Personalized medicine
JID - 101238549
RN  - 0 (Calgranulin A)
RN  - 0 (Calgranulin B)
RN  - 0 (S100A8 protein, human)
RN  - 0 (S100A9 protein, human)
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - Antiretroviral Therapy, Highly Active
MH  - Calgranulin A/genetics
MH  - Calgranulin B/genetics
MH  - Coinfection/genetics
MH  - Gene Expression Profiling/*methods
MH  - Gene Expression Regulation/drug effects
MH  - *Gene Regulatory Networks
MH  - Genome-Wide Association Study
MH  - HIV Infections/*drug therapy/genetics
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*genetics
MH  - Interferons/pharmacology/therapeutic use
MH  - Sequence Analysis, RNA
MH  - Tuberculosis/*genetics
MH  - Zinc Fingers
OTO - NOTNLM
OT  - DEG
OT  - HAART
OT  - HIV
OT  - TB-IRIS
OT  - ZNF
EDAT- 2018/07/10 06:00
MHDA- 2019/02/28 06:00
CRDT- 2018/07/10 06:00
PHST- 2018/07/10 06:00 [pubmed]
PHST- 2019/02/28 06:00 [medline]
PHST- 2018/07/10 06:00 [entrez]
AID - 10.2217/pme-2017-0084 [doi]
PST - ppublish
SO  - Per Med. 2018 Jul 1;15(4):251-269. doi: 10.2217/pme-2017-0084. Epub 2018 Jul 9.