PMID- 29985987 OWN - NLM STAT- MEDLINE DCOM- 20191224 LR - 20210330 IS - 1758-535X (Electronic) IS - 1079-5006 (Print) IS - 1079-5006 (Linking) VI - 74 IP - 3 DP - 2019 Feb 15 TI - Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood. PG - 283-289 LID - 10.1093/gerona/gly121 [doi] AB - Aging is characterized by deleterious immune and metabolic changes, but the onset of these changes is unknown. We measured immune and metabolic biomarkers in adults beginning at age 30. To our knowledge, this is the first study to evaluate these biomarkers in adults aged 30 to over 80. Biomarkers were quantified in 961 adults. Tumor necrosis factor alpha (TNF-alpha), tumor necrosis factor receptor I (TNFR-I), tumor necrosis factor receptor II (TNFR-II), interleukin (IL)-2, IL-6, VCAM-I, D-Dimer, G-CSF, regulated on activation, normal T cell expressed and secreted (RANTES), matrix metalloproteinase-3 (MMP-3), adiponectin, and paraoxonase activity were measured by ELISA. Acylcarnitines and amino acids (AAs) were measured by mass spectrometry and reduced to a single factor using principal components analysis (PCA). Glycine was analyzed separately. The relationship between age and biomarkers was analyzed by linear regression with sex, race, and body mass index (BMI) as covariates. Age was positively correlated with TNF-alpha, TNFR-I, TNFR-II, IL-6, IL-2, VCAM-1, D-Dimer, MMP-3, adiponectin, acylcarnitines, and AAs. Age was negative correlated with G-CSF, RANTES, and paraoxonase activity. BMI was significant for all biomarkers except IL-2, VCAM-1, RANTES, paraoxonase activity, and the AA factor. Excluding MMP-3, greater BMI was associated with potentially adverse changes in biomarker concentrations. Age-related changes in immune and metabolic biomarkers, known to be associated with poor outcomes in older adults, begin as early as the thirties. CI - (c) The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. FAU - Parker, Daniel AU - Parker D AD - Division of Geriatrics, Duke University School of Medicine, Durham, North Carolina. AD - Department of Medicine, Duke University School of Medicine, Durham, North Carolina. AD - Claude D. Pepper Older Americans Independence Center/Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, North Carolina. FAU - Sloane, Richard AU - Sloane R AD - Claude D. Pepper Older Americans Independence Center/Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, North Carolina. FAU - Pieper, Carl F AU - Pieper CF AD - Claude D. Pepper Older Americans Independence Center/Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, North Carolina. AD - Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, North Carolina. FAU - Hall, Katherine S AU - Hall KS AD - Department of Medicine, Duke University School of Medicine, Durham, North Carolina. AD - Claude D. Pepper Older Americans Independence Center/Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, North Carolina. AD - Durham VA Medical Center, North Carolina. FAU - Kraus, Virginia B AU - Kraus VB AD - Department of Medicine, Duke University School of Medicine, Durham, North Carolina. AD - Claude D. Pepper Older Americans Independence Center/Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, North Carolina. AD - Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina. FAU - Kraus, William E AU - Kraus WE AD - Department of Medicine, Duke University School of Medicine, Durham, North Carolina. AD - Claude D. Pepper Older Americans Independence Center/Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, North Carolina. AD - Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina. AD - Division of Cardiology, Duke University School of Medicine, Durham, North Carolina. FAU - Huebner, Janet L AU - Huebner JL AD - Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina. FAU - Ilkayeva, Olga R AU - Ilkayeva OR AD - Claude D. Pepper Older Americans Independence Center/Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, North Carolina. AD - Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina. AD - Sarah W. Stedman Nutrition and Metabolism Center. FAU - Bain, James R AU - Bain JR AD - Claude D. Pepper Older Americans Independence Center/Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, North Carolina. AD - Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina. AD - Sarah W. Stedman Nutrition and Metabolism Center. FAU - Newby, L Kristin AU - Newby LK AD - Department of Medicine, Duke University School of Medicine, Durham, North Carolina. AD - Division of Cardiology, Duke University School of Medicine, Durham, North Carolina. AD - Sarah W. Stedman Nutrition and Metabolism Center. AD - Duke Clinical and Translational Science Institute, Duke University School of Medicine, Durham, North Carolina. FAU - Cohen, Harvey Jay AU - Cohen HJ AD - Division of Geriatrics, Duke University School of Medicine, Durham, North Carolina. AD - Department of Medicine, Duke University School of Medicine, Durham, North Carolina. AD - Claude D. Pepper Older Americans Independence Center/Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, North Carolina. FAU - Morey, Miriam C AU - Morey MC AD - Division of Geriatrics, Duke University School of Medicine, Durham, North Carolina. AD - Department of Medicine, Duke University School of Medicine, Durham, North Carolina. AD - Claude D. Pepper Older Americans Independence Center/Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, North Carolina. AD - Durham VA Medical Center, North Carolina. LA - eng SI - ClinicalTrials.gov/NCT01720472 GR - P30 AG034424/AG/NIA NIH HHS/United States GR - R03 HD050374/HD/NICHD NIH HHS/United States GR - P30 AG028716/AG/NIA NIH HHS/United States GR - UL1 TR001117/TR/NCATS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PL - United States TA - J Gerontol A Biol Sci Med Sci JT - The journals of gerontology. Series A, Biological sciences and medical sciences JID - 9502837 RN - 0 (Biomarkers) RN - 0 (Cytokines) RN - 0 (Intercellular Signaling Peptides and Proteins) RN - 0 (Receptors, Tumor Necrosis Factor) SB - IM MH - Adult MH - Age Factors MH - Aged MH - Aged, 80 and over MH - Aging/*blood MH - Biomarkers/*blood MH - Body Mass Index MH - Cohort Studies MH - Cytokines/blood MH - Female MH - Health Status MH - Humans MH - Intercellular Signaling Peptides and Proteins/blood MH - Linear Models MH - Male MH - Middle Aged MH - Motor Activity MH - Receptors, Tumor Necrosis Factor/blood PMC - PMC6376106 OTO - NOTNLM OT - Biomarker OT - Functional impairment OT - Life span OT - Metabolism EDAT- 2018/07/10 06:00 MHDA- 2019/12/25 06:00 PMCR- 2019/05/22 CRDT- 2018/07/10 06:00 PHST- 2018/02/04 00:00 [received] PHST- 2018/07/10 06:00 [pubmed] PHST- 2019/12/25 06:00 [medline] PHST- 2018/07/10 06:00 [entrez] PHST- 2019/05/22 00:00 [pmc-release] AID - 5050151 [pii] AID - gly121 [pii] AID - 10.1093/gerona/gly121 [doi] PST - ppublish SO - J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):283-289. doi: 10.1093/gerona/gly121.