PMID- 29986171
OWN - NLM
STAT- MEDLINE
DCOM- 20190326
LR  - 20190326
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 268
DP  - 2018 Oct
TI  - Correlates of neurocognitive functions in individuals at ultra-high risk for 
      psychosis - A 6-month follow-up study.
PG  - 1-7
LID - S0165-1781(18)30343-3 [pii]
LID - 10.1016/j.psychres.2018.06.053 [doi]
AB  - Cognitive deficits are evident at the prodromal phase of psychosis. It has been 
      noted that brain-derived neurotrophic factor (BDNF) is correlated with cognition 
      in both preclinical and clinical studies. However, to our knowledge, no study has 
      evaluated blood BDNF levels and their association with cognitive impairment in 
      individuals at ultra-high risk for psychosis (UHR). We included 13 individuals at 
      UHR and 30 healthy controls (HC) matched by sex, age, and educational level. 
      Plasma BDNF levels were measured at baseline and 6 months. Neurocognitive 
      functions (executive functions, speed of processing, verbal learning and memory, 
      working memory) were examined at 6 months. Regression analyses were conducted to 
      examine the relationship between BDNF levels and cognitive performance. BDNF 
      levels were lower in UHR group than in HC group both at baseline and at 6 months 
      (P = 0.001, and P = 0.007, respectively). There were no associations between 
      plasma BDNF levels and all of the cognitive domains in both groups. Our findings 
      showed that peripheral BDNF levels were not related to cognitive deficits in UHR 
      and HC groups while the lower BDNF level in the former persisted up to 6 months. 
      Further research is needed in a large sample.
CI  - Copyright (c) 2018. Published by Elsevier B.V.
FAU - Sanada, Kenji
AU  - Sanada K
AD  - Department of Psychiatry, Showa University School of Medicine, Tokyo, Japan.
FAU - de Azua, Sonia Ruiz
AU  - de Azua SR
AD  - Department of Psychiatry, Araba University Hospital, BioAraba Research Institute, 
      OSI Araba Vitoria, Spain; Biomedical Research Networking Centre in Mental Health 
      (CIBERSAM), Madrid, Spain; University of the Basque Country.
FAU - Nakajima, Shinichiro
AU  - Nakajima S
AD  - Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
FAU - Alberich, Susana
AU  - Alberich S
AD  - Department of Psychiatry, Araba University Hospital, BioAraba Research Institute, 
      OSI Araba Vitoria, Spain; Biomedical Research Networking Centre in Mental Health 
      (CIBERSAM), Madrid, Spain.
FAU - Ugarte, Amaia
AU  - Ugarte A
AD  - Department of Psychiatry, Araba University Hospital, BioAraba Research Institute, 
      OSI Araba Vitoria, Spain; Biomedical Research Networking Centre in Mental Health 
      (CIBERSAM), Madrid, Spain.
FAU - Zugasti, Jone
AU  - Zugasti J
AD  - Department of Psychiatry, Araba University Hospital, BioAraba Research Institute, 
      OSI Araba Vitoria, Spain; Biomedical Research Networking Centre in Mental Health 
      (CIBERSAM), Madrid, Spain.
FAU - Vega, Patricia
AU  - Vega P
AD  - Department of Psychiatry, Araba University Hospital, BioAraba Research Institute, 
      OSI Araba Vitoria, Spain; Biomedical Research Networking Centre in Mental Health 
      (CIBERSAM), Madrid, Spain.
FAU - Martinez-Cengotitabengoa, Monica
AU  - Martinez-Cengotitabengoa M
AD  - Department of Psychiatry, Araba University Hospital, BioAraba Research Institute, 
      OSI Araba Vitoria, Spain; Biomedical Research Networking Centre in Mental Health 
      (CIBERSAM), Madrid, Spain; University of the Basque Country; National Distance 
      Education University (UNED), Spain.
FAU - Gonzalez-Pinto, Ana
AU  - Gonzalez-Pinto A
AD  - Department of Psychiatry, Araba University Hospital, BioAraba Research Institute, 
      OSI Araba Vitoria, Spain; Biomedical Research Networking Centre in Mental Health 
      (CIBERSAM), Madrid, Spain; University of the Basque Country. Electronic address: 
      anamaria.gonzalez-pintoarrillaga@osakidetza.eus.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180628
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Cognition/physiology
MH  - Cognition Disorders/blood/*diagnosis/*psychology
MH  - Executive Function/physiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Memory, Short-Term/physiology
MH  - *Mental Status and Dementia Tests
MH  - Psychotic Disorders/blood/*diagnosis/*psychology
MH  - Risk Factors
MH  - Time Factors
MH  - Young Adult
EDAT- 2018/07/10 06:00
MHDA- 2019/03/27 06:00
CRDT- 2018/07/10 06:00
PHST- 2018/02/24 00:00 [received]
PHST- 2018/06/12 00:00 [revised]
PHST- 2018/06/21 00:00 [accepted]
PHST- 2018/07/10 06:00 [pubmed]
PHST- 2019/03/27 06:00 [medline]
PHST- 2018/07/10 06:00 [entrez]
AID - S0165-1781(18)30343-3 [pii]
AID - 10.1016/j.psychres.2018.06.053 [doi]
PST - ppublish
SO  - Psychiatry Res. 2018 Oct;268:1-7. doi: 10.1016/j.psychres.2018.06.053. Epub 2018 
      Jun 28.