PMID- 29986173
OWN - NLM
STAT- MEDLINE
DCOM- 20190326
LR  - 20190326
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 268
DP  - 2018 Oct
TI  - The relationship between negative symptoms and cognitive functioning in patients 
      at clinical high risk for psychosis.
PG  - 21-27
LID - S0165-1781(18)30243-9 [pii]
LID - 10.1016/j.psychres.2018.06.047 [doi]
AB  - Negative symptoms and neurocognitive performance have been reported to be 
      negatively associated in patients with emerging psychosis. However, most previous 
      studies focused on patients with frank psychosis and did not differentiate 
      between subdomains of negative symptoms. Hence, we aimed to elucidate the 
      specific relationship between negative symptoms and cognitive functioning in 
      patients at clinical high risk (CHR) for psychosis. Data from 154 CHR patients 
      collected within the prospective Fruherkennung von Psychosen (FePsy) study were 
      analyzed. Negative symptoms were assessed with the Scale for the Assessment of 
      Negative Symptoms (SANS) and cognitive functioning with an extensive 
      neuropsychological test battery. Regression analyses revealed significant 
      negative associations between negative symptoms and cognitive functioning, 
      particularly in the domains of nonverbal intelligence and verbal fluency. When 
      analyzing each negative symptom domain separately, alogia and 
      asociality/anhedonia were significantly negatively associated with nonverbal 
      intelligence and alogia additionally with verbal fluency. Overall, our results in 
      CHR patients are similar to those reported in patients with frank psychosis. The 
      strong negative association between verbal fluency and negative symptoms may be 
      indicative of an overlap between these constructs. Verbal fluency might have a 
      strong influence on the clinical impression of negative symptoms (particularly 
      alogia) and vice versa.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Leanza, Letizia
AU  - Leanza L
AD  - Center for Gender Research and Early Detection, University of Basel Psychiatric 
      Hospital (UPK), Wilhelm Klein-Strasse 27, CH-4002 Basel, Switzerland; University 
      of Basel, Department of Psychology, Division of Clinical Psychology and 
      Epidemiology, Basel, Switzerland.
FAU - Egloff, Laura
AU  - Egloff L
AD  - Center for Gender Research and Early Detection, University of Basel Psychiatric 
      Hospital (UPK), Wilhelm Klein-Strasse 27, CH-4002 Basel, Switzerland; University 
      of Basel, Department of Psychology, Division of Clinical Psychology and 
      Epidemiology, Basel, Switzerland.
FAU - Studerus, Erich
AU  - Studerus E
AD  - Center for Gender Research and Early Detection, University of Basel Psychiatric 
      Hospital (UPK), Wilhelm Klein-Strasse 27, CH-4002 Basel, Switzerland.
FAU - Andreou, Christina
AU  - Andreou C
AD  - Center for Gender Research and Early Detection, University of Basel Psychiatric 
      Hospital (UPK), Wilhelm Klein-Strasse 27, CH-4002 Basel, Switzerland.
FAU - Heitz, Ulrike
AU  - Heitz U
AD  - Center for Gender Research and Early Detection, University of Basel Psychiatric 
      Hospital (UPK), Wilhelm Klein-Strasse 27, CH-4002 Basel, Switzerland.
FAU - Ittig, Sarah
AU  - Ittig S
AD  - Center for Gender Research and Early Detection, University of Basel Psychiatric 
      Hospital (UPK), Wilhelm Klein-Strasse 27, CH-4002 Basel, Switzerland.
FAU - Beck, Katharina
AU  - Beck K
AD  - Center for Gender Research and Early Detection, University of Basel Psychiatric 
      Hospital (UPK), Wilhelm Klein-Strasse 27, CH-4002 Basel, Switzerland; University 
      of Basel, Department of Psychology, Division of Clinical Psychology and 
      Epidemiology, Basel, Switzerland.
FAU - Uttinger, Martina
AU  - Uttinger M
AD  - Center for Gender Research and Early Detection, University of Basel Psychiatric 
      Hospital (UPK), Wilhelm Klein-Strasse 27, CH-4002 Basel, Switzerland.
FAU - Riecher-Rossler, Anita
AU  - Riecher-Rossler A
AD  - Center for Gender Research and Early Detection, University of Basel Psychiatric 
      Hospital (UPK), Wilhelm Klein-Strasse 27, CH-4002 Basel, Switzerland. Electronic 
      address: anita.riecher@upkbs.ch.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180621
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adult
MH  - Cognition/*physiology
MH  - Cognition Disorders/diagnosis/psychology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - *Neuropsychological Tests
MH  - Prospective Studies
MH  - Psychotic Disorders/*diagnosis/*psychology
MH  - Risk Factors
MH  - Young Adult
EDAT- 2018/07/10 06:00
MHDA- 2019/03/27 06:00
CRDT- 2018/07/10 06:00
PHST- 2018/02/06 00:00 [received]
PHST- 2018/05/28 00:00 [revised]
PHST- 2018/06/17 00:00 [accepted]
PHST- 2018/07/10 06:00 [pubmed]
PHST- 2019/03/27 06:00 [medline]
PHST- 2018/07/10 06:00 [entrez]
AID - S0165-1781(18)30243-9 [pii]
AID - 10.1016/j.psychres.2018.06.047 [doi]
PST - ppublish
SO  - Psychiatry Res. 2018 Oct;268:21-27. doi: 10.1016/j.psychres.2018.06.047. Epub 
      2018 Jun 21.