PMID- 29986408 OWN - NLM STAT- MEDLINE DCOM- 20181115 LR - 20181115 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 19 IP - 7 DP - 2018 Jul 6 TI - Schisandra chinensis Fructus and Its Active Ingredients as Promising Resources for the Treatment of Neurological Diseases. LID - 10.3390/ijms19071970 [doi] LID - 1970 AB - Neurological diseases (NDs) are a leading cause of death worldwide and tend to mainly affect people under the age of 50. High rates of premature death and disability caused by NDs undoubtedly constrain societal development. However, effective therapeutic drugs and methods are very limited. Schisandra chinensis Fructus (SCF) is the dry ripe fruit of Schisandra chinensis (Turcz.) Baill, which has been used in traditional Chinese medicine for thousands of years. Recent research has indicated that SCF and its active ingredients show a protective role in NDs, including cerebrovascular diseases, neurodegenerative diseases, or depression. The key neuroprotective mechanisms of SCF and its active ingredients have been demonstrated to include antioxidation, suppression of apoptosis, anti-inflammation, regulation of neurotransmitters, and modulation of brain-derived neurotrophic factor (BDNF) related pathways. This paper summarizes studies of the role of SCF and its active ingredients in protecting against NDs, and highlights them as promising resources for future treatment. Furthermore, novel insights on the future challenges of SCF and its active ingredients are offered. FAU - Zhang, Minyu AU - Zhang M AUID- ORCID: 0000-0002-9197-3283 AD - School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China. zhangminyu@ccmu.edu.cn. AD - Beijing Key Lab of TCM Collateral Disease Theory Research, Capital Medical University, Beijing 100069, China. zhangminyu@ccmu.edu.cn. FAU - Xu, Liping AU - Xu L AD - School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China. xulp@ccmu.edu.cn. AD - Beijing Key Lab of TCM Collateral Disease Theory Research, Capital Medical University, Beijing 100069, China. xulp@ccmu.edu.cn. FAU - Yang, Hongjun AU - Yang H AD - Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. hongjun0420@vip.sina.com. LA - eng PT - Journal Article PT - Review DEP - 20180706 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Antioxidants) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Drugs, Chinese Herbal) RN - 0 (Neurotransmitter Agents) SB - IM MH - Animals MH - Anti-Inflammatory Agents, Non-Steroidal/pharmacology/therapeutic use MH - Antioxidants/pharmacology/therapeutic use MH - Apoptosis/drug effects MH - Brain-Derived Neurotrophic Factor/drug effects MH - Drugs, Chinese Herbal/chemistry/isolation & purification/*therapeutic use MH - Fruit/*chemistry MH - Humans MH - Models, Animal MH - Nervous System Diseases/*therapy MH - Neurotransmitter Agents/pharmacology/therapeutic use MH - Oxidative Stress/drug effects MH - Schisandra/*chemistry PMC - PMC6073455 OTO - NOTNLM OT - Schisandra chinensis Fructus OT - active ingredients OT - molecular mechanism OT - neurological diseases COIS- The authors declare no conflict of interest. EDAT- 2018/07/11 06:00 MHDA- 2018/11/16 06:00 PMCR- 2018/07/01 CRDT- 2018/07/11 06:00 PHST- 2018/05/30 00:00 [received] PHST- 2018/06/28 00:00 [revised] PHST- 2018/06/30 00:00 [accepted] PHST- 2018/07/11 06:00 [entrez] PHST- 2018/07/11 06:00 [pubmed] PHST- 2018/11/16 06:00 [medline] PHST- 2018/07/01 00:00 [pmc-release] AID - ijms19071970 [pii] AID - ijms-19-01970 [pii] AID - 10.3390/ijms19071970 [doi] PST - epublish SO - Int J Mol Sci. 2018 Jul 6;19(7):1970. doi: 10.3390/ijms19071970.