PMID- 29987125 OWN - NLM STAT- MEDLINE DCOM- 20191104 LR - 20220410 IS - 2047-9980 (Electronic) IS - 2047-9980 (Linking) VI - 7 IP - 14 DP - 2018 Jul 9 TI - Periprocedural Cardiopulmonary Bypass or Venoarterial Extracorporeal Membrane Oxygenation During Transcatheter Aortic Valve Replacement: A Systematic Review. LID - 10.1161/JAHA.118.009608 [doi] LID - e009608 AB - BACKGROUND: There are limited data on the use of venoarterial extracorporeal membrane oxygenation (VA-ECMO) or cardiopulmonary bypass (CPB) to provide hemodynamic support periprocedurally during transcatheter aortic valve replacement. This study sought to evaluate patients receiving transcatheter aortic valve replacement with concomitant use of CPB/VA-ECMO. METHODS AND RESULTS: We systematically reviewed the published literature from 2000 to 2018 for studies evaluating adult patients requiring CPB/VA-ECMO periprocedurally during transcatheter aortic valve replacement. Studies reporting short-term and long-term mortality were included. Given the significant methodological and statistical differences between published studies, meta-analysis of the association of CPB/VA-ECMO with mortality was not performed. Of the 537 studies identified, 9 studies representing 5191 patients met our inclusion criteria. Median ages were between 75 and 87 years with 33% to 75% male patients. Where reported, the Edwards SAPIEN transcatheter heart valve was the most frequently used. A total of 203 (3.9%) patients received periprocedural hemodynamic support with CPB/VA-ECMO. Common indications for CPB/VA-ECMO included left ventricular or aortic annular rupture, rapid hemodynamic deterioration, aortic regurgitation, cardiac arrest, and left main coronary artery obstruction. The use of CPB/VA-ECMO was predominantly an emergent strategy and was used for durations of 1 to 2 hours. Short-term mortality (in-hospital and 30-day) was 29.8%, and 1-year mortality was 52.4%. Major complications such as bleeding, vascular injury, tamponade, stroke, and renal failure were noted in 10% to 50% of patients. CONCLUSIONS: CPB/VA-ECMO was used in 4% in the early experience of patients undergoing transcatheter aortic valve replacement, most commonly for periprocedural complications. There are limited data on preprocedural planned use of VA-ECMO, and the characteristics of this population remain poorly defined. CI - (c) 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. FAU - Vallabhajosyula, Saraschandra AU - Vallabhajosyula S AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. FAU - Patlolla, Sri Harsha AU - Patlolla SH AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. FAU - Sandhyavenu, Harigopal AU - Sandhyavenu H AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. FAU - Vallabhajosyula, Saarwaani AU - Vallabhajosyula S AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. FAU - Barsness, Gregory W AU - Barsness GW AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. FAU - Dunlay, Shannon M AU - Dunlay SM AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. FAU - Greason, Kevin L AU - Greason KL AD - Department of Cardiovascular Surgery, Mayo Clinic, Rochester, MN. FAU - Holmes, David R Jr AU - Holmes DR Jr AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. FAU - Eleid, Mackram F AU - Eleid MF AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN eleid.mackram@mayo.edu. LA - eng PT - Journal Article PT - Systematic Review DEP - 20180709 PL - England TA - J Am Heart Assoc JT - Journal of the American Heart Association JID - 101580524 SB - IM MH - Aortic Valve/*surgery MH - Aortic Valve Stenosis/*surgery MH - Cardiopulmonary Bypass/*methods MH - Extracorporeal Membrane Oxygenation/*methods MH - Global Health MH - Humans MH - Incidence MH - Postoperative Complications/*epidemiology MH - Transcatheter Aortic Valve Replacement/*methods PMC - PMC6064861 OTO - NOTNLM OT - cardiogenic shock OT - cardiopulmonary bypass OT - critical care OT - mechanical circulatory support OT - transcatheter valve implantation EDAT- 2018/07/11 06:00 MHDA- 2019/11/05 06:00 PMCR- 2018/07/17 CRDT- 2018/07/11 06:00 PHST- 2018/07/11 06:00 [entrez] PHST- 2018/07/11 06:00 [pubmed] PHST- 2019/11/05 06:00 [medline] PHST- 2018/07/17 00:00 [pmc-release] AID - JAHA.118.009608 [pii] AID - JAH33350 [pii] AID - 10.1161/JAHA.118.009608 [doi] PST - epublish SO - J Am Heart Assoc. 2018 Jul 9;7(14):e009608. doi: 10.1161/JAHA.118.009608.