PMID- 29987620
OWN - NLM
STAT- MEDLINE
DCOM- 20190801
LR  - 20200306
IS  - 1860-2002 (Electronic)
IS  - 1536-1632 (Linking)
VI  - 21
IP  - 2
DP  - 2019 Apr
TI  - Linked Hexokinase and Glucose-6-Phosphatase Activities Reflect Grade of Ovarian 
      Malignancy.
PG  - 375-381
LID - 10.1007/s11307-018-1247-2 [doi]
AB  - PURPOSE: Malignant cells exhibit increased rates of aerobic glycolysis. Here, we 
      tested whether the accumulation of fluoro-deoxyglucose-6-phosphate (FDG6P) in 
      ovarian cancers of differential malignancy reflects inversely correlated 
      elevations of hexokinase (HK) and glucose-6-phosphatase (G6Pase) activities. 
      PROCEDURES: Twenty-nine women with suspected ovarian cancer had positron emission 
      tomography (PET) prior to surgery. From fresh-frozen tissue, we determined the 
      activities of HK and G6Pase, and from the PET images, we determined the tumor 
      maximum standardized uptake value (SUVmax) of 2-deoxy-2-[(18)F]fluoro-D-glucose. 
      RESULTS: The SUVmax of malignant lesions significantly exceeded the SUVmax of 
      benign (p < 0.005) and borderline lesions (p < 0.0005) that did not differ 
      significantly. We found no significant correlation between measured HK or G6Pase 
      activities and histological tumor type or SUVmax except that G6Pase activities 
      were higher in malignant than borderline lesions (p < 0.05). Measured HK and 
      G6Pase activities correlated inversely (p < 0.05). The slopes from the regression 
      lines of the three correlations yielded positively correlated abscissa and 
      ordinate intercepts, designated HK(max) and G6Pase(max), respectively (r = 0.67, 
      p < 0.0001). The positive correlations between the abscissa and ordinate 
      intercepts with SUVmax had regression coefficients of r = 0.44, p < 0.05; and 
      r = 0.39, p < 0.05, respectively. CONCLUSIONS: The results distinguished two 
      ovarian cancer phenotypes, one with elevated HK activity and low G6Pase activity, 
      and another with the opposite characteristics.
FAU - Olsen, Birgitte Brinkmann
AU  - Olsen BB
AUID- ORCID: 0000-0002-6130-0387
AD  - Department of Nuclear Medicine, Odense University Hospital, Klovervaenget 47, 
      5000, Odense, Denmark. birgitte.brinkmann.olsen@rsyd.dk.
AD  - Department of Clinical Research, University of Southern Denmark, Odense, Denmark. 
      birgitte.brinkmann.olsen@rsyd.dk.
FAU - Gjedde, Albert
AU  - Gjedde A
AD  - Department of Nuclear Medicine, Odense University Hospital, Klovervaenget 47, 
      5000, Odense, Denmark.
AD  - Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
FAU - Vilstrup, Mie Holm
AU  - Vilstrup MH
AD  - Department of Nuclear Medicine, Odense University Hospital, Klovervaenget 47, 
      5000, Odense, Denmark.
FAU - Johnsen, Iben Birgit Gade
AU  - Johnsen IBG
AD  - Department of Clinical Pathology, Odense University Hospital, Odense, Denmark.
FAU - Neumann, Gudrun
AU  - Neumann G
AD  - Department of Gynecology and Obstetrics, Odense University Hospital, Odense, 
      Denmark.
FAU - Torigian, Drew Avedis
AU  - Torigian DA
AD  - Department of Radiology, University of Pennsylvania School of Medicine, Hospital 
      of the University of Pennsylvania, Philadelphia, USA.
FAU - Alavi, Abass
AU  - Alavi A
AD  - Department of Radiology, University of Pennsylvania School of Medicine, Hospital 
      of the University of Pennsylvania, Philadelphia, USA.
FAU - Hoilund-Carlsen, Poul Flemming
AU  - Hoilund-Carlsen PF
AD  - Department of Nuclear Medicine, Odense University Hospital, Klovervaenget 47, 
      5000, Odense, Denmark.
AD  - Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Mol Imaging Biol
JT  - Molecular imaging and biology
JID - 101125610
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 3.1.3.9 (Glucose-6-Phosphatase)
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Fluorodeoxyglucose F18/pharmacokinetics
MH  - Glucose-6-Phosphatase/*metabolism
MH  - Hexokinase/*metabolism
MH  - Humans
MH  - Middle Aged
MH  - Ovarian Neoplasms/*enzymology
OTO - NOTNLM
OT  - FDG
OT  - Glucose-6-phosphatase
OT  - Hexokinase
OT  - Ovarian cancer
OT  - Positron emission tomography (PET)
EDAT- 2018/07/11 06:00
MHDA- 2019/08/02 06:00
CRDT- 2018/07/11 06:00
PHST- 2018/07/11 06:00 [pubmed]
PHST- 2019/08/02 06:00 [medline]
PHST- 2018/07/11 06:00 [entrez]
AID - 10.1007/s11307-018-1247-2 [pii]
AID - 10.1007/s11307-018-1247-2 [doi]
PST - ppublish
SO  - Mol Imaging Biol. 2019 Apr;21(2):375-381. doi: 10.1007/s11307-018-1247-2.