PMID- 29989328
OWN - NLM
STAT- MEDLINE
DCOM- 20190207
LR  - 20190215
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 11
IP  - 1
DP  - 2019 Jan
TI  - Alcohol consumption, depressive symptoms, and the incidence of diabetes-related 
      complications.
PG  - 14-22
LID - 10.1111/1753-0407.12822 [doi]
AB  - BACKGROUND: Heavy alcohol consumption in individuals with type 2 diabetes 
      mellitus (T2DM) is related to increased risks of diabetes-related micro- and 
      macrovascular complications. Depressive symptoms may be relevant to this 
      relationship, because high depressive symptoms are associated with an increased 
      risk of complications. This study investigated whether the interaction between 
      depressive symptoms and alcohol frequency was positively related to the 
      development of neuropathy, retinopathy, nephropathy, and coronary artery disease 
      (CAD), such that those with high depressive symptoms and high alcohol frequency 
      will be at increased risk of complications. METHODS: Data were from five waves of 
      the Evaluation of Diabetes Treatment annual survey including 1413 adults with 
      T2DM in Quebec. Data on alcohol frequency (number of drinking occasions), 
      depressive symptoms, and complications were collected annually. The development 
      of each complication was investigated using multiple logistic regression analysis 
      with generalized estimating equations. RESULTS: After adjusting for 
      sociodemographic, lifestyle, and diabetes-related covariates, the interaction 
      between alcohol frequency and depressive symptoms was positively related to the 
      incidence of neuropathy and CAD, such that those with high depressive symptoms 
      who drank the most frequently had the highest risk of neuropathy (odds ratio [OR] 
      1.02, 95% confidence interval [CI] 1.00-1.04; P = 0.04) and CAD (OR 1.02, 95% CI 
      1.00-1.04; P = 0.04). This interaction was not significantly related to 
      retinopathy or nephropathy. CONCLUSION: Individuals with high depressive symptoms 
      and high alcohol frequency may have a particularly high risk of neuropathy and 
      CAD. Future prevention efforts should examine both alcohol frequency and 
      depressive symptoms when evaluating the risk of complications.
CI  - (c) 2018 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John 
      Wiley & Sons Australia, Ltd.
FAU - Elgendy, Randa
AU  - Elgendy R
AD  - Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, 
      Canada.
AD  - Douglas Mental Health University Institute, Montreal, Canada.
FAU - Deschenes, Sonya S
AU  - Deschenes SS
AD  - Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, 
      Canada.
AD  - Douglas Mental Health University Institute, Montreal, Canada.
FAU - Burns, Rachel J
AU  - Burns RJ
AD  - Department of Psychology, Carleton University, Ottawa, Canada.
FAU - Levy, Melanie
AU  - Levy M
AD  - Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, 
      Canada.
AD  - Douglas Mental Health University Institute, Montreal, Canada.
FAU - Schmitz, Norbert
AU  - Schmitz N
AUID- ORCID: 0000-0001-7777-6323
AD  - Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, 
      Canada.
AD  - Douglas Mental Health University Institute, Montreal, Canada.
AD  - Department of Epidemiology and Biostatistics, Faculty of Medicine, McGill 
      University, Montreal, Canada.
LA  - eng
GR  - MOP-106514/Canadian Institutes of Health Research/Canada
PT  - Journal Article
DEP - 20180806
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
SB  - IM
MH  - Aged
MH  - Alcohol Drinking/*epidemiology
MH  - Comorbidity
MH  - Coronary Artery Disease/epidemiology
MH  - Depression/*epidemiology
MH  - Diabetes Complications/*epidemiology
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Quebec/epidemiology
MH  - Risk Factors
OTO - NOTNLM
OT  - 2型糖尿病
OT  - alcohol
OT  - depressive symptoms
OT  - diabetes-related complications
OT  - type 2 diabetes mellitus
OT  - 抑郁症状
OT  - 糖尿病相关并发症
OT  - 酒精
EDAT- 2018/07/11 06:00
MHDA- 2019/02/08 06:00
CRDT- 2018/07/11 06:00
PHST- 2017/08/24 00:00 [received]
PHST- 2018/07/04 00:00 [revised]
PHST- 2018/07/05 00:00 [accepted]
PHST- 2018/07/11 06:00 [pubmed]
PHST- 2019/02/08 06:00 [medline]
PHST- 2018/07/11 06:00 [entrez]
AID - 10.1111/1753-0407.12822 [doi]
PST - ppublish
SO  - J Diabetes. 2019 Jan;11(1):14-22. doi: 10.1111/1753-0407.12822. Epub 2018 Aug 6.