PMID- 29989537
OWN - NLM
STAT- MEDLINE
DCOM- 20191004
LR  - 20191007
IS  - 1540-9740 (Print)
IS  - 1540-9740 (Linking)
VI  - 16
IP  - 3
DP  - 2018
TI  - Behcet Disease: New Developments in the Etiopathogenesis of an Old Silk Road 
      Disease.
PG  - 176-181
AB  - Behcet disease (BD) is a systemic inflammatory disorder that affects the skin, 
      mucosa, eyes, joints, blood vessels, brain, and gastrointestinal tract. The 
      etiopathogenesis of BD has not yet been fully elucidated, but disorganized immune 
      responses against the stimuli of environmental triggering factors have been 
      considered to play a major role in the pathogenesis of the disease in individuals 
      with genetic susceptibility. Human leukocyte antigen (HLA)-B*51 is known to be 
      the main factor involved in genetic susceptibility to BD. Among the environmental 
      factors, infectious agents in particular are thought to be important. 
      Immunological abnormalities could thus be the cornerstone in the development of 
      BD. Along with cytokines that play a role in disease pathogenesis, numerous other 
      cytokines have been recently identified or have been the focus of recent studies. 
      This contribution sheds light on the etiopathogenesis and immunology of BD in 
      relation to the current literature.
FAU - Ozlu, Emin
AU  - Ozlu E
AD  - Department of Dermatology, Duzce University School of Medicine, Duzce, Turkey.
FAU - Karadag, Ayse Serap
AU  - Karadag AS
AD  - Department of Dermatology, Istanbul Medeniyet University School of Medicine, 
      Istanbul, Turkey; karadagaserap@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180601
PL  - United States
TA  - Skinmed
JT  - Skinmed
JID - 101168327
SB  - IM
MH  - Behcet Syndrome/*etiology/pathology/therapy
MH  - Humans
EDAT- 2018/07/11 06:00
MHDA- 2019/10/08 06:00
CRDT- 2018/07/11 06:00
PHST- 2018/07/11 06:00 [entrez]
PHST- 2018/07/11 06:00 [pubmed]
PHST- 2019/10/08 06:00 [medline]
PST - epublish
SO  - Skinmed. 2018 Jun 1;16(3):176-181. eCollection 2018.