PMID- 29990625
OWN - NLM
STAT- MEDLINE
DCOM- 20190410
LR  - 20211204
IS  - 1096-1186 (Electronic)
IS  - 1043-6618 (Linking)
VI  - 135
DP  - 2018 Sep
TI  - Targeting mTORs by omega-3 fatty acids: A possible novel therapeutic strategy for 
      neurodegeneration?
PG  - 37-48
LID - S1043-6618(18)30531-0 [pii]
LID - 10.1016/j.phrs.2018.07.004 [doi]
AB  - Neurodegenerative diseases (NDs) such as Parkinson's (PD), Alzheimer's (AD), 
      Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) cause 
      significant world-wide morbidity and mortality. To date, there is no drug of cure 
      for these, mostly age-related diseases, although approaches in delaying the 
      pathology and/or giving patients some symptomatic relief have been adopted for 
      the last few decades. Various studies in recent years have shown the beneficial 
      effects of omega-3 poly unsaturated fatty acids (PUFAs) through diverse 
      mechanisms including anti-inflammatory effects. This review now assesses the 
      potential of this class of compounds in NDs therapy through specific action 
      against the mammalian target of rapamycin (mTOR) signaling pathway. The role of 
      mTOR in neurodegenerative diseases and targeted therapies by PUFAs are discussed.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Shirooie, Samira
AU  - Shirooie S
AD  - Department of Pharmacology, Faculty of Pharmacy, Kermanshah University of Medical 
      Sciences, Kermanshah, Iran.
FAU - Nabavi, Seyed Fazel
AU  - Nabavi SF
AD  - Pharmaceutical Sciences Research Center, Kermanshah University of Medical 
      Sciences, Kermanshah, Iran; Applied Biotechnology Research Center, Baqiyatallah 
      University of Medical Sciences, Tehran 14359-16471, Iran.
FAU - Dehpour, Ahmad R
AU  - Dehpour AR
AD  - Department of Pharmacology, Faculty of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran; Experimental Medicine Research Center, Tehran University 
      of Medical Sciences, Tehran, Iran.
FAU - Belwal, Tarun
AU  - Belwal T
AD  - G.B. Pant National Institute of Himalayan Environment and Sustainable 
      Development, Kosi Katarmal, Almora, Uttarakhand, India.
FAU - Habtemariam, Solomon
AU  - Habtemariam S
AD  - Pharmacognosy Research Laboratories & Herbal Analysis Services UK, University of 
      Greenwich, Chatham-Maritime, Kent ME4 4TB, UK.
FAU - Arguelles, Sandro
AU  - Arguelles S
AD  - Department of Physiology, Faculty of Pharmacy, University of Seville, Seville, 
      Spain.
FAU - Sureda, Antoni
AU  - Sureda A
AD  - Research Group on Community Nutrition and Oxidative Stress (NUCOX) and CIBEROBN 
      (Physiopathology of Obesity and Nutrition CB12/03/30038), University of Balearic 
      Islands, Palma de Mallorca E-07122, Balearic Islands, Spain.
FAU - Daglia, Maria
AU  - Daglia M
AD  - Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology 
      Section, University of Pavia, Italy.
FAU - Tomczyk, Michal
AU  - Tomczyk M
AD  - Department of Pharmacognosy, Faculty of Pharmacy, Medical University of 
      Bialystok, ul. Mickiewicza 2a, 15-230 Bialystok, Poland.
FAU - Sobarzo-Sanchez, Eduardo
AU  - Sobarzo-Sanchez E
AD  - Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of 
      Santiago de Compostela, 15782, Spain; Instituto de Investigacion en Innovacion en 
      Salud, Facultad de Ciencias de la Salud, Universidad Central de Chile, Santiago, 
      Chile.
FAU - Xu, Suowen
AU  - Xu S
AD  - Aab Cardiovascular Research Institute, University of Rochester, Rochester, NY 
      14623, United States.
FAU - Nabavi, Seyed Mohammad
AU  - Nabavi SM
AD  - Applied Biotechnology Research Center, Baqiyatallah University of Medical 
      Sciences, Tehran 14359-16471, Iran. Electronic address: Nabavi208@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180707
PL  - Netherlands
TA  - Pharmacol Res
JT  - Pharmacological research
JID - 8907422
RN  - 0 (Fatty Acids, Omega-3)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Fatty Acids, Omega-3/*pharmacology/therapeutic use
MH  - Humans
MH  - Neurodegenerative Diseases/drug therapy/*metabolism
MH  - Signal Transduction/drug effects
MH  - TOR Serine-Threonine Kinases/*metabolism
OTO - NOTNLM
OT  - Docosahexaenoic acid
OT  - Eicosapentaenoic acid
OT  - Neurodegenerative diseases
OT  - mTOR
OT  - omega-3
EDAT- 2018/07/11 06:00
MHDA- 2019/04/11 06:00
CRDT- 2018/07/11 06:00
PHST- 2018/04/15 00:00 [received]
PHST- 2018/07/03 00:00 [revised]
PHST- 2018/07/05 00:00 [accepted]
PHST- 2018/07/11 06:00 [pubmed]
PHST- 2019/04/11 06:00 [medline]
PHST- 2018/07/11 06:00 [entrez]
AID - S1043-6618(18)30531-0 [pii]
AID - 10.1016/j.phrs.2018.07.004 [doi]
PST - ppublish
SO  - Pharmacol Res. 2018 Sep;135:37-48. doi: 10.1016/j.phrs.2018.07.004. Epub 2018 Jul 
      7.