PMID- 29990734
OWN - NLM
STAT- MEDLINE
DCOM- 20181105
LR  - 20181105
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 162
DP  - 2018 Oct 30
TI  - Environmental toxicants impair liver and kidney function and sperm quality of 
      captive pandas.
PG  - 218-224
LID - S0147-6513(18)30599-2 [pii]
LID - 10.1016/j.ecoenv.2018.07.008 [doi]
AB  - Captive pandas are exposed to higher concentrations of environmental toxins in 
      their food source and from atmospheric pollution than wild pandas. Moreover, the 
      Qinling panda subspecies had significantly higher concentrations of toxic 
      chemicals in its feces. To determine whether these toxicants also accumulate in 
      panda's blood and impair its health, concentrations of persistent organic 
      pollutants (POPs) and heavy metals were measured in blood samples. Four heavy 
      metals (As, Cd, Cr and Pb), PCDD/Fs and PCBs were detected in blood drawn from 
      captive Qinling pandas. Time spent in captivity was a better predictor of 
      toxicant concentration accumulation than was panda age. More than 50% of the 
      studied pandas were outside the normal levels for 11 health parameters, and five 
      (ALT, LDH, Ca, Cl, TB) of the 11 parameters classified as abnormal were 
      correlated with blood pollutant concentrations. The proportion of live sperm was 
      significantly lower and the aberrance ratio of sperm was significantly greater 
      for captive pandas than for wild ones. A short-term solution to reduce the health 
      impacts of pollution and toxicant exposure of Qinling pandas is to relocate 
      breeding centers to less contaminated areas and to strictly control the quality 
      of their food provided. A longer term solution depends on improving air quality 
      by reducing toxic emissions.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Chen, Yi-Ping
AU  - Chen YP
AD  - SKLLQG, Institute of Earth Environment, Chinese Academy of Sciences, Xi'an 
      710075, China; College of Life Science, Northwest Normal University, Zhouzhi, 
      Lanzhou 730070, China. Electronic address: chenyp@ieecas.cn.
FAU - Liu, Qiang
AU  - Liu Q
AD  - SKLLQG, Institute of Earth Environment, Chinese Academy of Sciences, Xi'an 
      710075, China.
FAU - Ma, Qing-Yi
AU  - Ma QY
AD  - Shaanxi Wild Animal Research Center, Zhouzhi, Xi'an 710402, China.
FAU - Maltby, Lorraine
AU  - Maltby L
AD  - Departments of Animal and Plant Sciences, The University of Sheffield, Sheffield 
      S10 2TN, UK.
FAU - Ellison, Aaron M
AU  - Ellison AM
AD  - Harvard University, Harvard Forest, Petersham, MA, USA.
FAU - Zhao, Yan
AU  - Zhao Y
AD  - SKLLQG, Institute of Earth Environment, Chinese Academy of Sciences, Xi'an 
      710075, China.
LA  - eng
PT  - Journal Article
DEP - 20180711
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Environmental Pollutants)
RN  - 0 (Metals, Heavy)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - Environmental Pollutants/blood/*toxicity
MH  - Environmental Pollution
MH  - Kidney/*drug effects
MH  - Liver/*drug effects
MH  - Male
MH  - Metals, Heavy/blood/*toxicity
MH  - Polychlorinated Biphenyls/blood/toxicity
MH  - Semen Analysis/veterinary
MH  - Spermatozoa/*drug effects
MH  - Ursidae/*physiology
OTO - NOTNLM
OT  - Environment pollutants
OT  - Environmental toxins
OT  - Giant panda
OT  - Health effects
OT  - Heavy metals
OT  - POPs
EDAT- 2018/07/11 06:00
MHDA- 2018/11/06 06:00
CRDT- 2018/07/11 06:00
PHST- 2018/02/07 00:00 [received]
PHST- 2018/06/19 00:00 [revised]
PHST- 2018/07/01 00:00 [accepted]
PHST- 2018/07/11 06:00 [pubmed]
PHST- 2018/11/06 06:00 [medline]
PHST- 2018/07/11 06:00 [entrez]
AID - S0147-6513(18)30599-2 [pii]
AID - 10.1016/j.ecoenv.2018.07.008 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2018 Oct 30;162:218-224. doi: 
      10.1016/j.ecoenv.2018.07.008. Epub 2018 Jul 11.