PMID- 29990832
OWN - NLM
STAT- MEDLINE
DCOM- 20181214
LR  - 20200204
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 106
DP  - 2018 Oct
TI  - Morin attenuates doxorubicin-induced heart and brain damage by reducing oxidative 
      stress, inflammation and apoptosis.
PG  - 443-453
LID - S0753-3322(18)32527-7 [pii]
LID - 10.1016/j.biopha.2018.06.161 [doi]
AB  - Doxorubicin (DOX) is an effective antineoplastic agent of the anthracycline 
      group. However, as with most anticancer drugs, they cause some toxic effects, 
      including major cardiotoxicity and cognitive impairment. In this study, 
      protective effects of morin against DOX-induced cardiotoxicity and neurotoxicity 
      in rats were investigated. Morin was orally administered to rats at a dose of 50 
      and 100 mg/kg body weight for 10 days. DOX was administered 40 mg/kg body weight 
      by single dose intraperitoneal injection on the 8th day of the study. Both the 
      levels of glutathione (GSH) and malondialdehyde (MDA) were assessed and enzyme 
      activities of superoxide dismutase (SOD), catalase (CAT) and glutathione 
      peroxidase (GPx) were assessed to determine the protective effect of morin 
      against oxidative stress. To determine the anti-inflammatory effect, the levels 
      of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), nuclear factor kappa 
      B (NF-kappaB) were assessed in the heart and brain tissues. Lactate dehydrogenase 
      (LDH) and creatine kinase isoenzyme-MB (CKMB) activities, which are cardiac 
      function markers, and cardiac troponin-I (cTn-I) levels were also determined. 
      Anti-apoptotic effect was determined by anti-apoptotic protein B-cell lymphoma-2 
      (Bcl-2) and pro-apoptotic protein cysteine aspartate specific protease-3 
      (caspase-3) changes. The regulatory role of morin in signal transduction in the 
      brain tissue was assigned with the determination of amount of 
      acetylcholinesterase (AChE), and its healing effect on the central nervous system 
      was determined with imuinohistochemical detection of glial fibrillar acidic 
      protein (GFAP) level. Histopathological evaluation of heart and brain tissues was 
      performed in all groups.
CI  - Copyright (c) 2018 Elsevier Masson SAS. All rights reserved.
FAU - Kuzu, Muslum
AU  - Kuzu M
AD  - Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Ibrahim Cecen 
      University of Agri, Agri, Turkey. Electronic address: mkuzu@agri.edu.tr.
FAU - Kandemir, Fatih Mehmet
AU  - Kandemir FM
AD  - Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, 
      Erzurum, Turkey.
FAU - Yildirim, Serkan
AU  - Yildirim S
AD  - Department of Pathology, Faculty of Veterinary Medicine, Ataturk University, 
      Erzurum, Turkey.
FAU - Kucukler, Sefa
AU  - Kucukler S
AD  - Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, 
      Erzurum, Turkey.
FAU - Caglayan, Cuneyt
AU  - Caglayan C
AD  - Department of Biochemistry, Faculty of Veterinary Medicine, Bingol University, 
      Bingol, Turkey.
FAU - Turk, Erdinc
AU  - Turk E
AD  - Department of Pharmacy Professional Sciences, Faculty of Pharmacy, Ibrahim Cecen 
      University of Agri, Agri, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20180711
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Flavonoids)
RN  - 0 (GFAP protein, rat)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Inflammation Mediators)
RN  - 80168379AG (Doxorubicin)
RN  - 8NFQ3F76WR (morin)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
RN  - EC 3.1.1.7 (Ache protein, rat)
SB  - IM
MH  - Acetylcholinesterase/metabolism
MH  - Animals
MH  - Anti-Infective Agents/*pharmacology
MH  - Antioxidants/*pharmacology
MH  - Apoptosis/*drug effects
MH  - Apoptosis Regulatory Proteins/metabolism
MH  - Biomarkers/metabolism
MH  - Brain/*drug effects/metabolism/pathology
MH  - Brain Diseases/chemically induced/metabolism/pathology/*prevention & control
MH  - Cardiotoxicity
MH  - Cytokines/metabolism
MH  - Cytoprotection
MH  - Disease Models, Animal
MH  - *Doxorubicin
MH  - Flavonoids/*pharmacology
MH  - GPI-Linked Proteins/metabolism
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Heart Diseases/chemically induced/metabolism/pathology/*prevention & control
MH  - Inflammation/chemically induced/metabolism/pathology/*prevention & control
MH  - Inflammation Mediators/metabolism
MH  - Male
MH  - *Myocardium/metabolism/pathology
MH  - Oxidative Stress/*drug effects
MH  - Rats, Wistar
MH  - Signal Transduction/drug effects
OTO - NOTNLM
OT  - Apoptosis
OT  - Doxorubicin
OT  - Inflammation
OT  - Morin
OT  - Oxidative stress
EDAT- 2018/07/11 06:00
MHDA- 2018/12/15 06:00
CRDT- 2018/07/11 06:00
PHST- 2018/04/14 00:00 [received]
PHST- 2018/06/26 00:00 [revised]
PHST- 2018/06/27 00:00 [accepted]
PHST- 2018/07/11 06:00 [pubmed]
PHST- 2018/12/15 06:00 [medline]
PHST- 2018/07/11 06:00 [entrez]
AID - S0753-3322(18)32527-7 [pii]
AID - 10.1016/j.biopha.2018.06.161 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2018 Oct;106:443-453. doi: 10.1016/j.biopha.2018.06.161. 
      Epub 2018 Jul 11.