PMID- 29991950
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220318
IS  - 1710-1484 (Print)
IS  - 1710-1492 (Electronic)
IS  - 1710-1484 (Linking)
VI  - 14
DP  - 2018
TI  - Effect of artemisinin and neurectomy of pterygoid canal in ovalbumin-induced 
      allergic rhinitis mouse model.
PG  - 22
LID - 10.1186/s13223-018-0249-6 [doi]
LID - 22
AB  - BACKGROUND: Allergic rhinitis (AR), characterized by sneezing, nasal itching and 
      rhinorrhea, affects a large number of population. This study aimed to explore the 
      effects of artemisinin alone or combined with neurectomy of pterygoid canal in 
      ovalbumin-induced AR mouse model and illustrate the underlying mechanisms. 
      METHODS: Allergic symptoms were evaluated to verify inhibitory effect of 
      artemisinin alone or combined with neurectomy of pterygoid canal on AR. Serum 
      levels of histamine, immunoglobulin E (IgE) and inflammatory factors TNF, INF-gamma, 
      IL-1beta IL-10, IL-4 and IL-5 were measured by ELISA. The mRNA levels of TNF, INF-gamma, 
      IL-1beta and IL-10 in local lymph nodes were measured by RT-qPCR. The total and 
      phosphorylated levels of ERK and JNK were assessed by Western blot. 
      CD4(+)CD25(+)Foxp3(+) T (Treg) cells were analyzed by flow cytometry. RESULTS: 
      Artemisinin significantly relieved the behavior symptoms of AR mice. The 
      administration of artemisinin strikingly suppressed the expression of histamine, 
      IgE and inflammatory factors. An increased Treg cell proportion and inhibited ERK 
      phosphorylation were observed in artemisinin-treated groups as compared to those 
      in the AR group. Moreover, artemisinin plus neurectomy of pterygoid almost 
      abolished the behavioral score increase in AR mice. CONCLUSIONS: These results 
      indicated that artemisinin exhibited anti-allergic effect by inhibiting ERK 
      activation and increasing Treg cell proportion, which subsequently decreased the 
      expressions of allergic mediators. In addition, artemisinin combined with 
      neurectomy of pterygoid showed better efficacy than artemisinin alone.
FAU - Li, Jian
AU  - Li J
AD  - 1Departments of Otorhinolaryngology and Geriatrics, Cangzhou Central Hospital, 16 
      Xinhua West Road, Cangzhou, 061000 Hebei People's Republic of China. ISNI: 0000 
      0004 0614 4777. GRID: grid.452270.6
FAU - Wang, Bin
AU  - Wang B
AUID- ORCID: 0000-0001-7633-5665
AD  - 1Departments of Otorhinolaryngology and Geriatrics, Cangzhou Central Hospital, 16 
      Xinhua West Road, Cangzhou, 061000 Hebei People's Republic of China. ISNI: 0000 
      0004 0614 4777. GRID: grid.452270.6
FAU - Luo, Yingying
AU  - Luo Y
AD  - Departments of Pediatric Bone Oncology, Cangzhou Combine Traditional Chinese and 
      Western Medicine Hospital, 31 Huanghe West Road, Cangzhou, 061000 Hebei People's 
      Republic of China.
FAU - Bian, Yajie
AU  - Bian Y
AD  - Department of Dermatology, Langfang City Dacheng County Traditional Chinese 
      Medicine Hospital, Cultural Street, Langfang, 065900 Hebei People's Republic of 
      China.
FAU - Wang, Ruipei
AU  - Wang R
AD  - Department of Otorhinolaryngology and Geriatrics, Langfang City Dacheng County 
      Hospital, 47 Xinhua East Street, Langfang, 065900 Hebei People's Republic of 
      China.
LA  - eng
PT  - Journal Article
DEP - 20180611
PL  - England
TA  - Allergy Asthma Clin Immunol
JT  - Allergy, asthma, and clinical immunology : official journal of the Canadian 
      Society of Allergy and Clinical Immunology
JID - 101244313
PMC - PMC5994650
OTO - NOTNLM
OT  - Allergic rhinitis model
OT  - Artemisinin
OT  - ERK
OT  - Neurectomy of pterygoid
OT  - Treg cell
EDAT- 2018/07/12 06:00
MHDA- 2018/07/12 06:01
PMCR- 2018/06/11
CRDT- 2018/07/12 06:00
PHST- 2017/12/01 00:00 [received]
PHST- 2018/04/04 00:00 [accepted]
PHST- 2018/07/12 06:00 [entrez]
PHST- 2018/07/12 06:00 [pubmed]
PHST- 2018/07/12 06:01 [medline]
PHST- 2018/06/11 00:00 [pmc-release]
AID - 249 [pii]
AID - 10.1186/s13223-018-0249-6 [doi]
PST - epublish
SO  - Allergy Asthma Clin Immunol. 2018 Jun 11;14:22. doi: 10.1186/s13223-018-0249-6. 
      eCollection 2018.