PMID- 29994939
OWN - NLM
STAT- MEDLINE
DCOM- 20190122
LR  - 20190122
IS  - 1473-6500 (Electronic)
IS  - 0952-7907 (Linking)
VI  - 31
IP  - 5
DP  - 2018 Oct
TI  - Genetics and genomics in postoperative pain and analgesia.
PG  - 569-574
LID - 10.1097/ACO.0000000000000633 [doi]
AB  - PURPOSE OF REVIEW: The review describes recent advances in genetics and genomics 
      of postoperative pain, the association between genetic variants and the efficacy 
      of analgesics, and the role of pharmacogenomics in the selection of appropriate 
      analgesic treatments for postoperative pain. RECENT FINDINGS: Recent genetic 
      studies have reported associations of genetic variants in 
      catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF), 
      voltage-gated channel alpha subunit 11 (SCN11A) and mu-opioid receptor (OPRM1) 
      genes with postoperative pain. The recent pharmacogenetics studies revealed an 
      association of the organic cation transporter 1 (OCT1) and ATP-binding cassette 
      C3 (ABCC3) polymorphisms with morphine-related adverse effects, an effect of 
      polymorphisms in cytochrome P450 gene CYP2D6 on the analgesic efficacy of 
      tramadol and no effect of CYP2C8 and CYP2C9 variants on efficacy of piroxicam. 
      SUMMARY: Genetic variants associate with inter-individual variability in drug 
      responses and they can affect pain sensitivity and intensity of postoperative 
      pain. Despite the recent progress in genetics and genomics of postoperative pain, 
      it is still not possible to precisely predict the patients who are genetically 
      predisposed to have severe postoperative pain or who develop chronic 
      postoperative pain.
FAU - Palada, Vinko
AU  - Palada V
AD  - Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 
      Sweden.
FAU - Kaunisto, Mari A
AU  - Kaunisto MA
AD  - Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 
      Helsinki, Finland.
FAU - Kalso, Eija
AU  - Kalso E
AD  - Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 
      Sweden.
AD  - Pain Clinic, Department of Anaesthesiology, Intensive Care and Pain Medicine, 
      Helsinki University Hospital and University of Helsinki, Finland.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Anaesthesiol
JT  - Current opinion in anaesthesiology
JID - 8813436
SB  - IM
MH  - Genetic Variation
MH  - Humans
MH  - Pain Management
MH  - Pain, Postoperative/*drug therapy/*genetics
MH  - *Pharmacogenetics
EDAT- 2018/07/12 06:00
MHDA- 2019/01/23 06:00
CRDT- 2018/07/12 06:00
PHST- 2018/07/12 06:00 [pubmed]
PHST- 2019/01/23 06:00 [medline]
PHST- 2018/07/12 06:00 [entrez]
AID - 10.1097/ACO.0000000000000633 [doi]
PST - ppublish
SO  - Curr Opin Anaesthesiol. 2018 Oct;31(5):569-574. doi: 
      10.1097/ACO.0000000000000633.