PMID- 29995278
OWN - NLM
STAT- MEDLINE
DCOM- 20180925
LR  - 20190318
IS  - 1573-2959 (Electronic)
IS  - 0167-6369 (Linking)
VI  - 190
IP  - 8
DP  - 2018 Jul 11
TI  - Excretion kinetics of three dominant organochlorine compounds in human milk 
      within the first 6 months postpartum.
PG  - 457
LID - 10.1007/s10661-018-6850-9 [doi]
AB  - Breastfeeding is a specific and important way for women to eliminate harmful 
      substances accumulated in body. Hexachlorobenzene (HCB), beta-hexachlorocyclohexane 
      (beta-HCH), and 2,2-bis(p-chlorophenyl)-1,1-dichloroethene (p,p'-DDE) are dominant 
      organochlorine compounds(OCCs) and persistent organic pollutants (POPs) 
      accumulated in human being. Although a 6-month breastfeeding was suggested by the 
      World Health Organization (WHO), the excretion characteristics of OCCs in human 
      milk during the first 6-month lactation remain controversial. The main purpose of 
      this study was to continuously monitor the three dominant OCC concentrations and 
      reveal their elimination characteristic in human milk within the first 6-month 
      lactation. To do that, with one sample per month, during their first 6-month 
      lactation, human milk samples were continuously collected from 40 mothers after 
      their first birth. The result showed that the concentrations of the three OCCs in 
      human milk during the lactation continuously decreased from 51.7 to 39.9 mug/kg 
      milk lipids for HCB, from 136.5 to 84.8 mug/kg milk lipids for beta-HCH, and from 
      307.3 to 192 mug/kg milk lipids, respectively. The excretion kinetics of each 
      compound in milk lipids fitted zero-order kinetics during the 6-month lactation. 
      The excretion rate of the three OCCs was approximately 3% per month for HCB and 
      7% per month for the other two compounds during the lactation, with t(dec 1/2) of 
      13 months for HCB, 7.5 months for beta-HCH, and 8 months for p,p'-DDE. The excretion 
      rate of the target compounds depended on initial deposited levels, compound 
      properties, and exposure or input source.
FAU - Song, Shuling
AU  - Song S
AD  - National Research Center for Geoanalysis (NRCGA), CAGS, Beijing, 100037, China. 
      songshuling163@163.com.
FAU - Ma, Xiaodong
AU  - Ma X
AD  - College of Science, China Agricultural University, Beijing, 100193, China.
FAU - Pan, Meng
AU  - Pan M
AD  - National Research Center for Geoanalysis (NRCGA), CAGS, Beijing, 100037, China.
FAU - Tong, Ling
AU  - Tong L
AD  - National Research Center for Geoanalysis (NRCGA), CAGS, Beijing, 100037, China.
FAU - Tian, Qin
AU  - Tian Q
AD  - National Research Center for Geoanalysis (NRCGA), CAGS, Beijing, 100037, China.
LA  - eng
GR  - 41473008/National Natural Science Foundation of China/
GR  - 1212011120274/Geological Survey Project of China/
PT  - Journal Article
DEP - 20180711
PL  - Netherlands
TA  - Environ Monit Assess
JT  - Environmental monitoring and assessment
JID - 8508350
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - 4Z87H0LKUY (Hexachlorobenzene)
RN  - 59NEE7PCAB (Hexachlorocyclohexane)
RN  - YM80ODM9PD (beta-hexachlorocyclohexane)
SB  - IM
MH  - Adult
MH  - Breast Feeding
MH  - Dichlorodiphenyl Dichloroethylene/metabolism
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*metabolism
MH  - Female
MH  - Hexachlorobenzene/analysis/metabolism
MH  - Hexachlorocyclohexane/metabolism
MH  - Humans
MH  - Hydrocarbons, Chlorinated/analysis/*metabolism
MH  - Kinetics
MH  - Milk, Human/chemistry/*metabolism
MH  - Postpartum Period
OTO - NOTNLM
OT  - Dominant organochlorine compound
OT  - Excretion kinetics
OT  - Human milk
EDAT- 2018/07/12 06:00
MHDA- 2018/09/27 06:00
CRDT- 2018/07/12 06:00
PHST- 2018/02/26 00:00 [received]
PHST- 2018/07/03 00:00 [accepted]
PHST- 2018/07/12 06:00 [entrez]
PHST- 2018/07/12 06:00 [pubmed]
PHST- 2018/09/27 06:00 [medline]
AID - 10.1007/s10661-018-6850-9 [pii]
AID - 10.1007/s10661-018-6850-9 [doi]
PST - epublish
SO  - Environ Monit Assess. 2018 Jul 11;190(8):457. doi: 10.1007/s10661-018-6850-9.