PMID- 29995674
OWN - NLM
STAT- MEDLINE
DCOM- 20190520
LR  - 20190520
IS  - 1531-7013 (Electronic)
IS  - 1087-2418 (Linking)
VI  - 23
IP  - 4
DP  - 2018 Aug
TI  - Epitope-based human leukocyte antigen matching for transplantation: a personal 
      perspective of its future.
PG  - 486-492
LID - 10.1097/MOT.0000000000000539 [doi]
AB  - PURPOSE OF REVIEW: This study reflects my personal experience with the 
      characterization of human leukocyte antigen (HLA) epitopes and their significance 
      in HLA matching for transplantation. It offers a subjective assessment what 
      further studies are needed to have this concept be applied in the clinical 
      setting. RECENT FINDINGS: This study addresses the structural characteristics of 
      antibody-reactive HLA epitopes determined by different methods, eplet-associated 
      antibody analysis and acceptable mismatching for sensitized patients and eplet 
      immunogenicity and determination of mismatch permissibility. BASIC IMPLICATIONS: 
      for clinical practice and research consider the need for further studies of the 
      structural basis of antibody-verified HLA epitopes determined in different 
      techniques and their clinical relevance, the biological basis of epitope 
      immunogenicity and determinations of permissible mismatches and a computerized 
      clinical transplant database with an Artificial Intelligence component that can 
      generate evidence-based information for the practical application of 
      epitope-based HLA matching.
FAU - Duquesnoy, Rene J
AU  - Duquesnoy RJ
AD  - University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Organ Transplant
JT  - Current opinion in organ transplantation
JID - 9717388
RN  - 0 (Antibodies)
RN  - 0 (Epitopes)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Antibodies/immunology
MH  - Epitopes/*immunology
MH  - HLA Antigens/*immunology
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Organ Transplantation/*methods
MH  - Transplantation Immunology
EDAT- 2018/07/12 06:00
MHDA- 2019/05/21 06:00
CRDT- 2018/07/12 06:00
PHST- 2018/07/12 06:00 [entrez]
PHST- 2018/07/12 06:00 [pubmed]
PHST- 2019/05/21 06:00 [medline]
AID - 00075200-201808000-00018 [pii]
AID - 10.1097/MOT.0000000000000539 [doi]
PST - ppublish
SO  - Curr Opin Organ Transplant. 2018 Aug;23(4):486-492. doi: 
      10.1097/MOT.0000000000000539.