PMID- 29995756
OWN - NLM
STAT- MEDLINE
DCOM- 20180718
LR  - 20210109
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 28
DP  - 2018 Jul
TI  - Association of MCP-1 rs1024611 polymorphism with diabetic foot ulcers.
PG  - e11232
LID - 10.1097/MD.0000000000011232 [doi]
LID - e11232
AB  - Monocyte chemotactant protein-1 (MCP-1), a pro-inflammatory cytokine, plays an 
      important role in inflammatory process. In present study, we evaluated the 
      association of MCP-1 gene rs1024611 polymorphism with risk and clinical 
      characteristics of diabetic foot ulcers (DFUs).This study recruited 116 patients 
      with DFUs, 135 patients with diabetes mellitus (DM) without complications 
      (non-DFU), and 149 healthy controls (HCs). MCP-1 gene rs1024611 polymorphism was 
      genotyped by direct sequencing. The expression of MCP-1 was analyzed using 
      quantitative real-time polymerase chain reaction. Odds ratios (ORs) and 95% 
      confidence intervals (CIs) were used to assume the association 
      strength.Individuals with rs1024611 AG and GG genotypes exhibited significantly 
      higher susceptibility to DFUs, in the comparison with HCs (AG vs AA, OR = 2.364, 
      95% CI = 1.021-5.470; GG vs AA, OR = 2.686, 95% CI = 1.154-6.255). Meanwhile, G 
      allele was associated with increased DFUs susceptibility (OR = 1.457, 95% 
      CI = 1.014-2.093). Besides, rs1024611 SNP was slightly correlated with increased 
      DFUs susceptibility in patients with DM. GG genotype of rs1024611 was 
      significantly correlated with higher epidermal thickness and lower dermis 
      thickness in patients with DFUs (P < .01). Patients with DFU exhibited 
      upregulation of MCP-1 mRNA, and GG genotype was correlated with enhanced MCP-1 
      expression in DFU and non-DFU groups.Rs1024611 polymorphism was significantly 
      associated with MCP-1 expression and individual susceptibility to DFUs.
FAU - Su, Na
AU  - Su N
AD  - Department of Second Endocrinology Department of Second Ultrasound Department of 
      Medical Records, Cangzhou Central Hospital, Cangzhou, China.
FAU - Zhao, Nairui
AU  - Zhao N
FAU - Wang, Guangya
AU  - Wang G
FAU - Wang, Linxia
AU  - Wang L
FAU - Zhang, Yunna
AU  - Zhang Y
FAU - Li, Ruijie
AU  - Li R
FAU - Liu, Ying
AU  - Liu Y
FAU - Yang, Xinxin
AU  - Yang X
FAU - Li, Cuiliu
AU  - Li C
FAU - Hou, Mingming
AU  - Hou M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aged
MH  - Chemokine CCL2/*genetics
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Foot/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
PMC - PMC6076038
EDAT- 2018/07/12 06:00
MHDA- 2018/07/19 06:00
PMCR- 2018/07/13
CRDT- 2018/07/12 06:00
PHST- 2018/07/12 06:00 [entrez]
PHST- 2018/07/12 06:00 [pubmed]
PHST- 2018/07/19 06:00 [medline]
PHST- 2018/07/13 00:00 [pmc-release]
AID - 00005792-201807130-00007 [pii]
AID - MD-D-17-07949 [pii]
AID - 10.1097/MD.0000000000011232 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Jul;97(28):e11232. doi: 10.1097/MD.0000000000011232.