PMID- 29996002
OWN - NLM
STAT- MEDLINE
DCOM- 20190513
LR  - 20190513
IS  - 1468-1331 (Electronic)
IS  - 1351-5101 (Linking)
VI  - 25
IP  - 12
DP  - 2018 Dec
TI  - Study of the possible link of 25-hydroxyvitamin D with Epstein-Barr virus and 
      human herpesvirus 6 in patients with multiple sclerosis.
PG  - 1446-1453
LID - 10.1111/ene.13749 [doi]
AB  - BACKGROUND AND PURPOSE: Although the causes of multiple sclerosis (MS) remain 
      partially unknown, environmental and genetic factors are thought to play a role 
      in its aetiopathogenesis. Hypovitaminosis D, Epstein-Barr virus (EBV) and human 
      herpesvirus 6 (HHV-6) infections have been described as possible MS triggers. Our 
      aim was to analyse the possible link between 25-hydroxyvitamin D [25(OH)D] and 
      viruses in patients with MS. METHODS: We included 482 patients with MS in a 
      2-year study. Serum samples were collected to analyse 25(OH)D levels and, 
      according to sample availability, antibody titres against EBV and HHV-6 by 
      enzyme-linked immunosorbent assay. DNA was extracted from blood in order to 
      analyse EBV and HHV-6 viral load by quantitative real-time polymerase chain 
      reaction and to genotype MS-related single nucleotide polymorphisms (rs3135388, 
      rs2248359 and rs12368653) when possible. RESULTS: The 25(OH)D levels were 
      significantly higher in the first semester of the year than in the second. 
      Carriers of the risk allele rs2248359-C showed lower 25(OH)D levels than 
      non-carriers. For EBV, viral load was significantly higher when 25(OH)D levels 
      were low, demonstrating an inverse correlation between 25(OH)D levels and EBV 
      load. CONCLUSIONS: The 25(OH)D levels could be involved in the regulation of EBV 
      replication/reactivation in patients with MS.
CI  - (c) 2018 EAN.
FAU - Perez-Perez, S
AU  - Perez-Perez S
AUID- ORCID: 0000-0002-3899-8932
AD  - Grupo Investigacion EM, Hospital Clinico San Carlos, Instituto Investigacion 
      Sanitaria San Carlos (IdISSC), Madrid.
FAU - Dominguez-Mozo, M I
AU  - Dominguez-Mozo MI
AD  - Grupo Investigacion EM, Hospital Clinico San Carlos, Instituto Investigacion 
      Sanitaria San Carlos (IdISSC), Madrid.
FAU - Garcia-Martinez, M A
AU  - Garcia-Martinez MA
AD  - Grupo Investigacion EM, Hospital Clinico San Carlos, Instituto Investigacion 
      Sanitaria San Carlos (IdISSC), Madrid.
FAU - Aladro, Y
AU  - Aladro Y
AD  - Servicio Neurologia, Hospital Universitario Getafe, Getafe.
FAU - Martinez-Gines, M
AU  - Martinez-Gines M
AD  - Servicio Neurologia, Hospital General Universitario Gregorio Maranon, Madrid.
FAU - Garcia-Dominguez, J M
AU  - Garcia-Dominguez JM
AD  - Servicio Neurologia, Hospital General Universitario Gregorio Maranon, Madrid.
FAU - Lopez de Silanes, C
AU  - Lopez de Silanes C
AD  - Servicio Neurologia, Hospital Universitario Torrejon, Torrejon de Ardoz.
FAU - Casanova, I
AU  - Casanova I
AD  - Servicio Neurologia, Hospital Universitario Torrejon, Torrejon de Ardoz.
FAU - Ortega-Madueno, I
AU  - Ortega-Madueno I
AD  - Servicio Analisis Clinicos, Hospital Clinico San Carlos, Instituto Investigacion 
      Sanitaria San Carlos (IdISSC), Madrid.
FAU - Lopez-Lozano, L
AU  - Lopez-Lozano L
AD  - Servicio Analisis Clinicos, Hospital Clinico San Carlos, Instituto Investigacion 
      Sanitaria San Carlos (IdISSC), Madrid.
FAU - Torrejon, M J
AU  - Torrejon MJ
AD  - Servicio Analisis Clinicos, Hospital Clinico San Carlos, Instituto Investigacion 
      Sanitaria San Carlos (IdISSC), Madrid.
FAU - Arroyo, R
AU  - Arroyo R
AD  - Servicio Neurologia, Hospital Universitario Quironsalud Madrid, Madrid, Spain.
FAU - Alvarez-Lafuente, R
AU  - Alvarez-Lafuente R
AD  - Grupo Investigacion EM, Hospital Clinico San Carlos, Instituto Investigacion 
      Sanitaria San Carlos (IdISSC), Madrid.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180803
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
RN  - 1406-16-2 (Vitamin D)
RN  - A288AR3C9H (25-hydroxyvitamin D)
RN  - P6YZ13C99Q (Calcifediol)
SB  - IM
MH  - Adult
MH  - Calcifediol
MH  - Female
MH  - Herpesviridae Infections/*blood/virology
MH  - Herpesvirus 4, Human/*isolation & purification
MH  - Herpesvirus 6, Human/*isolation & purification
MH  - Humans
MH  - Male
MH  - Multiple Sclerosis/*blood/*virology
MH  - Viral Load
MH  - Vitamin D/*analogs & derivatives/blood
MH  - Young Adult
OTO - NOTNLM
OT  - Epstein-Barr virus
OT  - human herpesvirus 6
OT  - multiple sclerosis
OT  - vitamin D
EDAT- 2018/07/12 06:00
MHDA- 2019/05/14 06:00
CRDT- 2018/07/12 06:00
PHST- 2018/03/28 00:00 [received]
PHST- 2018/07/10 00:00 [accepted]
PHST- 2018/07/12 06:00 [pubmed]
PHST- 2019/05/14 06:00 [medline]
PHST- 2018/07/12 06:00 [entrez]
AID - 10.1111/ene.13749 [doi]
PST - ppublish
SO  - Eur J Neurol. 2018 Dec;25(12):1446-1453. doi: 10.1111/ene.13749. Epub 2018 Aug 3.