PMID- 29997434
OWN - NLM
STAT- MEDLINE
DCOM- 20181022
LR  - 20220318
IS  - 1178-1998 (Electronic)
IS  - 1176-9092 (Print)
IS  - 1176-9092 (Linking)
VI  - 13
DP  - 2018
TI  - Autonomic function as indicated by heart rate deceleration capacity and 
      deceleration runs in type 2 diabetes patients with or without essential 
      hypertension.
PG  - 1169-1176
LID - 10.2147/CIA.S149920 [doi]
AB  - PURPOSE: Sympathovagal imbalance is a common underlying disorder in hypertension 
      and diabetes. This study characterized autonomic nervous system function, 
      indicated by heart rate deceleration capacity (DC) and deceleration runs (DRs), 
      in patients with type 2 diabetes mellitus (T2DM), with or without concomitant 
      essential hypertension. SUBJECTS AND METHODS: We recruited 50 healthy subjects, 
      50 patients with T2DM, and 95 with T2DM and essential hypertension. DC, DRs 
      (DR(2), DR(4), and DR(8), ie, episodes of 2, 4, or 8 consecutive beat-to-beat 
      heart rate decelerations, respectively), and heart rate variability were 
      determined by dynamic electrocardiogram. Biochemical markers of glucose and lipid 
      metabolism, including glycated hemoglobin (HbA1c) and high-density lipoprotein 
      cholesterol (HDL-C), were measured from blood samples. RESULTS: Both T2DM groups 
      featured lower DC, SD of all normal-to-normal sinus RR intervals over 24 h 
      (SDNN), root mean square of the successive normal sinus RR interval difference, 
      and all DR values, but higher average heart rate (AHR) and acceleration capacity 
      (AC), than healthy subjects. There were significant associations between the 
      following: DC and HbA1c, systolic blood pressure (SBP), AHR, age, and HDL-C; 
      DR(2) and AHR, SBP, and HbA1c; DR(4) and HbA1c, age, SBP, and HDL-C; and DR(8) 
      and HbA1c, AHR, and age. In both T2DM groups, HbA1c correlated negatively with 
      DC, DR(2), and SDNN, and positively with AC and AHR; homeostasis model 
      assessment-insulin resistance index correlated negatively with DC, all DRs, and 
      SDNN, and positively with AC. CONCLUSION: Compared with healthy subjects, T2DM 
      patients with or without essential hypertension have lower DC and DRs. DC and DRs 
      correlate negatively with blood glucose and insulin resistance index.
FAU - Wang, Xing-De
AU  - Wang XD
AD  - Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's 
      Hospital, Shanghai 200233, China.
FAU - Zhou, Li
AU  - Zhou L
AD  - Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's 
      Hospital, Shanghai 200233, China.
FAU - Zhu, Chao-Yu
AU  - Zhu CY
AD  - Department of Endocrinology, Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Shanghai 200233, China, weili63@hotmail.com.
FAU - Chen, Bin
AU  - Chen B
AD  - Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's 
      Hospital, Shanghai 200233, China.
FAU - Chen, Zhong
AU  - Chen Z
AD  - Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's 
      Hospital, Shanghai 200233, China.
FAU - Wei, Li
AU  - Wei L
AD  - Department of Endocrinology, Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Shanghai 200233, China, weili63@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20180702
PL  - New Zealand
TA  - Clin Interv Aging
JT  - Clinical interventions in aging
JID - 101273480
SB  - IM
MH  - Adult
MH  - Autonomic Nervous System/physiopathology
MH  - Case-Control Studies
MH  - *Deceleration
MH  - Diabetes Mellitus, Type 2/complications/*physiopathology
MH  - Electrocardiography, Ambulatory
MH  - Essential Hypertension/complications/*physiopathology
MH  - Female
MH  - Fetal Heart/*physiopathology
MH  - Heart Rate/physiology
MH  - Humans
MH  - Insulin Resistance
MH  - Male
MH  - Middle Aged
PMC - PMC6033089
OTO - NOTNLM
OT  - autonomic nervous system
OT  - deceleration capacity of heart rate
OT  - heart rate deceleration runs
OT  - hypertension
OT  - insulin resistance
OT  - type 2 diabetes mellitus
COIS- Disclosure The authors report no conflicts of interest in this work.
EDAT- 2018/07/13 06:00
MHDA- 2018/10/23 06:00
PMCR- 2018/07/02
CRDT- 2018/07/13 06:00
PHST- 2018/07/13 06:00 [entrez]
PHST- 2018/07/13 06:00 [pubmed]
PHST- 2018/10/23 06:00 [medline]
PHST- 2018/07/02 00:00 [pmc-release]
AID - cia-13-1169 [pii]
AID - 10.2147/CIA.S149920 [doi]
PST - epublish
SO  - Clin Interv Aging. 2018 Jul 2;13:1169-1176. doi: 10.2147/CIA.S149920. eCollection 
      2018.