PMID- 29997519
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 9
DP  - 2018
TI  - Acute Effects of High Intensity, Resistance, or Combined Protocol on the Increase 
      of Level of Neurotrophic Factors in Physically Inactive Overweight Adults: The 
      BrainFit Study.
PG  - 741
LID - 10.3389/fphys.2018.00741 [doi]
LID - 741
AB  - The purpose of this study was to compare the neurotrophic factor response 
      following one session of high-intensity exercise, resistance training or both in 
      a cohort of physically inactive overweight adults aged 18-30 years old. A 
      randomized, parallel-group clinical trial of 51 men (23.6 +/- 3.5 years; 83.5 +/- 7.8 
      kg; 28.0 +/- 1.9 kg/m(2)) who are physically inactive (i.e., < 150 min of 
      moderate-intensity exercise per week or IPAQ score of <600 MET min/week for >6 
      months) and are either abdominally obese (waist circumference >/=90 cm) or have a 
      body mass index, BMI >/=25 and </= 30 kg/m(2) were randomized to the following four 
      exercise protocols: high-intensity exercise (4 x 4 min intervals at 85-95% 
      maximum heart rate [HRmax] interspersed with 4 min of recovery at 75-85% HRmax) 
      (n = 14), resistance training (12-15 repetitions per set, at 50-70% of one 
      repetition maximum with 60 s of recovery) (n = 12), combined high-intensity and 
      resistance exercise (n = 13), or non-exercising control (n = 12). The plasma 
      levels of neurotrophin-3 (NT-3), neurotrophin-4 (also known as neurotrophin 4/5; 
      NT-4 or NT-4/5), and brain-derived neurotrophic factor (BDNF) were determined 
      before (pre-exercise) and 1-min post-exercise for each protocol session. 
      Resistance training induced significant increases in NT-3 (+39.6 ng/mL [95% CI, 
      2.5-76.6; p = 0.004], and NT-4/5 (+1.3 ng/mL [95% CI, 0.3-2.3; p = 0.014]), 
      respectively. Additionally, combined training results in favorable effects on 
      BDNF (+22.0, 95% CI, 2.6-41.5; p = 0.029) and NT-3 (+32.9 ng/mL [95% CI, 
      12.3-53.4; p = 0.004]), respectively. The regression analysis revealed a 
      significant positive relationship between changes in BDNF levels and changes in 
      NT-4/5 levels from baseline to immediate post-exercise in the combined training 
      group (R(2) = 0.345, p = 0.034) but not the other intervention groups. The 
      findings indicate that acute resistance training and combined exercise increase 
      neurotrophic factors in physically inactive overweight adults. Further studies 
      are required to determine the biological importance of changes in neurotrophic 
      responses in overweight men and chronic effects of these exercise protocols. 
      TRIAL REGISTRATION: ClinicalTrials.gov, NCT02915913 (Date: September 22, 2016).
FAU - Dominguez-Sanchez, Maria A
AU  - Dominguez-Sanchez MA
AD  - Grupo de Investigacion Movimiento Corporal Humano, Facultad de Enfermeria y 
      Rehabilitacion, Universidad de La Sabana, Chia, Colombia.
FAU - Bustos-Cruz, Rosa H
AU  - Bustos-Cruz RH
AD  - Evidence-Based Therapeutic Group, Clinical Pharmacology, Universidad de La 
      Sabana, Bogota, Colombia.
FAU - Velasco-Orjuela, Gina P
AU  - Velasco-Orjuela GP
AD  - Centro de Estudios en Medicion de la Actividad Fisica, Escuela de Medicina y 
      Ciencias de la Salud, Universidad del Rosario, Bogota, Colombia.
FAU - Quintero, Andrea P
AU  - Quintero AP
AD  - Centro de Estudios en Medicion de la Actividad Fisica, Escuela de Medicina y 
      Ciencias de la Salud, Universidad del Rosario, Bogota, Colombia.
FAU - Tordecilla-Sanders, Alejandra
AU  - Tordecilla-Sanders A
AD  - Centro de Estudios en Medicion de la Actividad Fisica, Escuela de Medicina y 
      Ciencias de la Salud, Universidad del Rosario, Bogota, Colombia.
FAU - Correa-Bautista, Jorge E
AU  - Correa-Bautista JE
AD  - Centro de Estudios en Medicion de la Actividad Fisica, Escuela de Medicina y 
      Ciencias de la Salud, Universidad del Rosario, Bogota, Colombia.
FAU - Triana-Reina, Hector R
AU  - Triana-Reina HR
AD  - Grupo GICAEDS, Programa de Cultura Fisica, Deporte y Recreacion, Universidad 
      Santo Tomas, Bogota, Colombia.
FAU - Garcia-Hermoso, Antonio
AU  - Garcia-Hermoso A
AD  - Laboratorio de Ciencias de la Actividad Fisica, el Deporte y la Salud, 
      Universidad de Santiago de Chile, Santiago, Chile.
FAU - Gonzalez-Ruiz, Katherine
AU  - Gonzalez-Ruiz K
AD  - Grupo de Ejercicio Fisico y Deportes, Facultad de Salud, Programa de 
      Fisioterapia, Universidad Manuela Beltran, Bogota, Colombia.
FAU - Pena-Guzman, Carlos A
AU  - Pena-Guzman CA
AD  - Facultad de Ingenieria Ambiental, Grupo de Investigacion INAM-USTA Universidad 
      Santo Tomas, Bogota, Colombia.
FAU - Hernandez, Enrique
AU  - Hernandez E
AD  - Centro de Estudios en Medicion de la Actividad Fisica, Escuela de Medicina y 
      Ciencias de la Salud, Universidad del Rosario, Bogota, Colombia.
FAU - Pena-Ibagon, Jhonatan C
AU  - Pena-Ibagon JC
AD  - Centro de Estudios en Medicion de la Actividad Fisica, Escuela de Medicina y 
      Ciencias de la Salud, Universidad del Rosario, Bogota, Colombia.
FAU - Tellez-T, Luis A
AU  - Tellez-T LA
AD  - Centro de Estudios en Medicion de la Actividad Fisica, Escuela de Medicina y 
      Ciencias de la Salud, Universidad del Rosario, Bogota, Colombia.
FAU - Izquierdo, Mikel
AU  - Izquierdo M
AD  - Department of Health Sciences, Public University of Navarra, Navarrabiomed, CIBER 
      of Frailty and Healthy Aging (CIBERFES) Instituto de Salud Carlos III, Pamplona, 
      Spain.
FAU - Ramirez-Velez, Robinson
AU  - Ramirez-Velez R
AD  - Centro de Estudios en Medicion de la Actividad Fisica, Escuela de Medicina y 
      Ciencias de la Salud, Universidad del Rosario, Bogota, Colombia.
LA  - eng
SI  - ClinicalTrials.gov/NCT02915913
PT  - Journal Article
DEP - 20180627
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC6030369
OTO - NOTNLM
OT  - exercise
OT  - inactivity
OT  - neurotrophic factors
OT  - obesity
OT  - plasticity
EDAT- 2018/07/13 06:00
MHDA- 2018/07/13 06:01
PMCR- 2018/06/27
CRDT- 2018/07/13 06:00
PHST- 2017/11/25 00:00 [received]
PHST- 2018/05/28 00:00 [accepted]
PHST- 2018/07/13 06:00 [entrez]
PHST- 2018/07/13 06:00 [pubmed]
PHST- 2018/07/13 06:01 [medline]
PHST- 2018/06/27 00:00 [pmc-release]
AID - 10.3389/fphys.2018.00741 [doi]
PST - epublish
SO  - Front Physiol. 2018 Jun 27;9:741. doi: 10.3389/fphys.2018.00741. eCollection 
      2018.