PMID- 29998121
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220318
IS  - 2296-9381 (Print)
IS  - 2296-9357 (Electronic)
IS  - 2296-9357 (Linking)
VI  - 4
IP  - 2
DP  - 2018 Jun
TI  - The Genetic and Environmental Factors of Primary Membranous Nephropathy: An 
      Overview from China.
PG  - 65-73
LID - 10.1159/000487136 [doi]
AB  - BACKGROUND: Primary membranous nephropathy (pMN) is the most common cause of 
      nephrotic syndrome in adults. The discovery of the 2 autoantigens, M-type 
      phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A 
      (THSD7A), has defined pMN as an autoimmune disease. A remarkable increase in the 
      frequency of pMN in primary glomerular disease was witnessed in China. The 
      genetic and environmental contributors to disease susceptibility have been 
      investigated in these patients. SUMMARY: We reviewed recent publications in 
      genetic and environmental studies of pMN, focusing mainly on those undertaken in 
      China. Following a genome-wide association study, the gene-gene interaction 
      between the 2 most significant risk factors, PLA2R1 and DQA1, was validated in 
      Chinese patients with MN. Fine mapping on human leukocyte antigen (HLA) locus 
      found that DRB1*1501 and DRB1*0301 were risk alleles. Three amino acid residues 
      on positions 13 and 71 of HLA-DRbeta1 chain may confer the susceptibility to pMN by 
      presenting T-cell epitopes on PLA2R. Another study found that DRB3*0202 was the 
      most likely culprit allele for the signal at DRB1*0301. One environmental risk 
      factor for pMN has been identified as the long-term exposure to high levels of 
      PM(2.5) in Chinese patients with MN. Each 10 mug/m(3) increase in PM(2.5) 
      concentration was associated with 14% higher odds for pMN in the regions with 
      PM(2.5) above 70 mug/m(3). KEY MESSAGE: A gene-environment interaction is 
      suspected as an underlying mechanism for the increasing trend of pMN in China.
FAU - Zhang, Xiao-Dan
AU  - Zhang XD
AD  - Renal Division, Department of Medicine, Peking University First Hospital, 
      Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, 
      Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, 
      Ministry of Education of China, Beijing, China.
FAU - Cui, Zhao
AU  - Cui Z
AD  - Renal Division, Department of Medicine, Peking University First Hospital, 
      Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, 
      Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, 
      Ministry of Education of China, Beijing, China.
FAU - Zhao, Ming-Hui
AU  - Zhao MH
AD  - Renal Division, Department of Medicine, Peking University First Hospital, 
      Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, 
      Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, 
      Ministry of Education of China, Beijing, China.
AD  - Peking-Tsinghua Center for Life Sciences, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180404
PL  - Switzerland
TA  - Kidney Dis (Basel)
JT  - Kidney diseases (Basel, Switzerland)
JID - 101658365
PMC - PMC6029227
OTO - NOTNLM
OT  - Autoimmune response
OT  - Disease susceptibility
OT  - Environment pollution
OT  - Genetic studies
OT  - Membranous nephropathy
EDAT- 2018/07/13 06:00
MHDA- 2018/07/13 06:01
PMCR- 2019/06/01
CRDT- 2018/07/13 06:00
PHST- 2017/10/02 00:00 [received]
PHST- 2018/01/18 00:00 [accepted]
PHST- 2018/07/13 06:00 [entrez]
PHST- 2018/07/13 06:00 [pubmed]
PHST- 2018/07/13 06:01 [medline]
PHST- 2019/06/01 00:00 [pmc-release]
AID - kdd-0004-0065 [pii]
AID - 10.1159/000487136 [doi]
PST - ppublish
SO  - Kidney Dis (Basel). 2018 Jun;4(2):65-73. doi: 10.1159/000487136. Epub 2018 Apr 4.