PMID- 29998612
OWN - NLM
STAT- Publisher
LR  - 20240227
IS  - 1365-2826 (Electronic)
IS  - 0953-8194 (Linking)
DP  - 2018 Jul 12
TI  - Role of AMPA and NMDA receptors on vasopressin and oxytocin secretion induced by 
      hypertonic extracellular volume expansion.
PG  - e12633
LID - 10.1111/jne.12633 [doi]
AB  - Vasopressin (AVP) and oxytocin (OT) are essential for the control of 
      extracellular fluid osmolality and volume. Secretion of these hormones is 
      modulated by several mechanisms, including NMDA and AMPA L-glutamate receptors in 
      magnocellular cells of paraventricular (PVN) and supraoptic (SON) hypothalamic 
      nuclei. Thus, to better understand the participation of L-glutamate on the 
      neuroendocrine control of AVP and OT, this work evaluated the effects of 
      intracerebroventricular (icv) NMDA and AMPA receptor antagonists on plasma AVP 
      and OT levels induced by extracellular volume expansion (EVE). Cannulated rats 
      received icv NMDA (AP5) and AMPA (NBQX) antagonists in 10 and 30nmol/5mul/rat 
      doses and were subjected to either isotonic (0.15 M NaCl, 2ml/100g) or hypertonic 
      (0.30 M NaCl, 2ml/100g) EVE. Blood samples were collected for plasma AVP and OT 
      determination. Isotonic EVE did not change plasma AVP and OT levels, but 
      hypertonic EVE increased both AVP and OT plasma levels. AP5 reduced plasma AVP, 
      but it did not change the OT level induced by hypertonic EVE. On the other hand, 
      NBQX reduced plasma OT, but did not alter the AVP plasma level. Our data shows 
      that L-glutamate controls the secretion of neurohypophyseal hormones through the 
      NMDA receptor for AVP release, and through the AMPA receptor for OT release, both 
      in response to hypertonic EVE. This article is protected by copyright. All rights 
      reserved.
CI  - This article is protected by copyright. All rights reserved.
FAU - Vilhena-Franco, Tatiane
AU  - Vilhena-Franco T
AD  - Department of Physiology Ribeirao, Preto Medical School, Sao Paulo University, 
      Ribeirao Preto, Sao Paulo, Brazil.
FAU - Valentim-Lima, Evandro
AU  - Valentim-Lima E
AD  - Department of Physiological Sciences, Institute of Biological and Health 
      Sciences, Federal Rural University of Rio de Janeiro, Seropedica, Rio de Janeiro, 
      Brazil.
FAU - Reis, Luis C
AU  - Reis LC
AD  - Department of Physiological Sciences, Institute of Biological and Health 
      Sciences, Federal Rural University of Rio de Janeiro, Seropedica, Rio de Janeiro, 
      Brazil.
FAU - Elias, Lucila L K
AU  - Elias LLK
AD  - Department of Physiology Ribeirao, Preto Medical School, Sao Paulo University, 
      Ribeirao Preto, Sao Paulo, Brazil.
FAU - Antunes-Rodrigues, Jose
AU  - Antunes-Rodrigues J
AD  - Department of Physiology Ribeirao, Preto Medical School, Sao Paulo University, 
      Ribeirao Preto, Sao Paulo, Brazil.
FAU - Mecawi, Andre S
AU  - Mecawi AS
AD  - Department of Physiological Sciences, Institute of Biological and Health 
      Sciences, Federal Rural University of Rio de Janeiro, Seropedica, Rio de Janeiro, 
      Brazil.
LA  - eng
PT  - Journal Article
DEP - 20180712
PL  - United States
TA  - J Neuroendocrinol
JT  - Journal of neuroendocrinology
JID - 8913461
OTO - NOTNLM
OT  - L-glutamate
OT  - extracellular volume
OT  - neurohypophysis
OT  - plasma osmolality
EDAT- 2018/07/13 06:00
MHDA- 2018/07/13 06:00
CRDT- 2018/07/13 06:00
PHST- 2018/07/13 06:00 [entrez]
PHST- 2018/07/13 06:00 [pubmed]
PHST- 2018/07/13 06:00 [medline]
AID - 10.1111/jne.12633 [doi]
PST - aheadofprint
SO  - J Neuroendocrinol. 2018 Jul 12:e12633. doi: 10.1111/jne.12633.