PMID- 30001659
OWN - NLM
STAT- MEDLINE
DCOM- 20201112
LR  - 20201112
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 33
IP  - 5
DP  - 2020 Mar
TI  - The association of parental methylenetetrahydrofolate reductase polymorphisms 
      (MTHFR 677C > T and 1298A > C) and fetal loss: a case-control study in South 
      Australia.
PG  - 752-757
LID - 10.1080/14767058.2018.1500546 [doi]
AB  - Objective: To determine the association between parental MTHFR 677C > T 
      (RS1801133) and 1298A > C (RS1801131), and fetal loss (FL).Design: Case-control 
      study.Setting: Department of Obstetrics and Gynecology, Lyell McEwin Hospital 
      (LMH), and the Women's and Children's Hospital (WCH) in Adelaide, 
      Australia.Patients: A total of 222 couples with FL and 988 couples with 
      uncomplicated pregnancies.Measurements: The main outcomes were FL and 
      hyperhomocysteinemia (HHcy). All couples were tested for MTHFR 677C > T and 
      1298A > C. Fasting homocysteine was measured in the women with FL.Results: The 
      main finding was a significant difference between the FL group and controls in 
      couples with >/=4 abnormal alleles compared to <4 [p=.0232, OR 1.9 (95% CI 
      1.1-3.3)]. None of the couples with FL had zero abnormal alleles (both parents 
      677CC/1298 AA). However, this was also rare amongst the controls. Maternal 
      carriage of both 677C > T and the 1298A > C polymorphisms was similar between the 
      FL group and controls. The prevalence of paternal 677TT/1298AA and 677CC/1298AC 
      was significantly higher in the FL group compared with controls. HHcy was 
      significantly more common in the FL group compared with controls.Conclusion: The 
      presence of parental MTHFR 677C > T and 1298A > C is associated with FL. The 
      association between maternal MTHFR genotypes with FL is less pronounced than in 
      previously published articles investigating first trimester miscarriages. 
      Maternal HHcy is a significant risk factor for FL.
FAU - Kos, Britt J P
AU  - Kos BJP
AD  - Adelaide Medical School, Robinson Research Institute, University of Adelaide, 
      Adelaide, Australia.
AD  - Women and Children's Division, Lyell McEwin Hospital, Elizabeth Vale, South 
      Australia, Australia.
FAU - Leemaqz, Shalem Y
AU  - Leemaqz SY
AD  - Adelaide Medical School, Robinson Research Institute, University of Adelaide, 
      Adelaide, Australia.
FAU - McCormack, Catherine D
AU  - McCormack CD
AUID- ORCID: 0000-0002-6209-6904
AD  - Women's and Children's Hospital, North Adelaide, Adelaide, Australia.
FAU - Andraweera, Prabha H
AU  - Andraweera PH
AUID- ORCID: 0000-0003-2434-8370
AD  - Adelaide Medical School, Robinson Research Institute, University of Adelaide, 
      Adelaide, Australia.
FAU - Furness, Denise L
AU  - Furness DL
AUID- ORCID: 0000-0002-1075-0257
AD  - Adelaide Medical School, Robinson Research Institute, University of Adelaide, 
      Adelaide, Australia.
FAU - Roberts, Claire T
AU  - Roberts CT
AUID- ORCID: 0000-0002-9250-2192
AD  - Adelaide Medical School, Robinson Research Institute, University of Adelaide, 
      Adelaide, Australia.
FAU - Dekker, Gustaaf A
AU  - Dekker GA
AD  - Adelaide Medical School, Robinson Research Institute, University of Adelaide, 
      Adelaide, Australia.
AD  - Women and Children's Division, Lyell McEwin Hospital, Elizabeth Vale, South 
      Australia, Australia.
LA  - eng
PT  - Journal Article
DEP - 20180919
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the 
      European Association of Perinatal Medicine, the Federation of Asia and Oceania 
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
RN  - EC 1.5.1.20 (MTHFR protein, human)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Abortion, Spontaneous/*genetics
MH  - Adult
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
MH  - Polymorphism, Single Nucleotide
MH  - Pregnancy
OTO - NOTNLM
OT  - Fetal loss
OT  - MTHFR
OT  - hyperhomocysteinemia
OT  - methylenetetrahydrofolate reductase
OT  - pregnancy loss
EDAT- 2018/07/14 06:00
MHDA- 2020/11/13 06:00
CRDT- 2018/07/14 06:00
PHST- 2018/07/14 06:00 [pubmed]
PHST- 2020/11/13 06:00 [medline]
PHST- 2018/07/14 06:00 [entrez]
AID - 10.1080/14767058.2018.1500546 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2020 Mar;33(5):752-757. doi: 
      10.1080/14767058.2018.1500546. Epub 2018 Sep 19.