PMID- 30003423
OWN - NLM
STAT- MEDLINE
DCOM- 20190624
LR  - 20190624
IS  - 1573-8221 (Electronic)
IS  - 0007-4888 (Linking)
VI  - 165
IP  - 3
DP  - 2018 Jul
TI  - Directed Change in TNFalpha Specificity to Create DR5 Antagonists.
PG  - 386-389
LID - 10.1007/s10517-018-4176-9 [doi]
AB  - Death receptor 5 (DR5) is a promising target for antitumor therapy due to its 
      high expression on different tumor cells. Resistance of various tumor cells 
      against TRAIL, a natural ligand for the death receptors, reduces its therapeutic 
      potential and prompts the search for novel agonists at these receptors. Previous 
      screening across the combinatorial peptide library yielded a peptide sequence 
      KVVLTHR that specifically binds DR5. Incorporation of this sequence into TNFalpha 
      resulted in binding DR5 with mutant protein TNFalpha-mut and appearance of 
      cytotoxicity against lymphoma cells.
FAU - Ukrainskaya, V M
AU  - Ukrainskaya VM
AD  - Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of 
      Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
FAU - Bobik, T V
AU  - Bobik TV
AD  - Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of 
      Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
FAU - Argentova-Stevens, A
AU  - Argentova-Stevens A
AD  - Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of 
      Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
FAU - Slutskaya, E A
AU  - Slutskaya EA
AD  - Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of 
      Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
FAU - Kalinin, R S
AU  - Kalinin RS
AD  - Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of 
      Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
FAU - Gabibov, A G
AU  - Gabibov AG
AD  - Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of 
      Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
FAU - Stepanov, A V
AU  - Stepanov AV
AD  - Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of 
      Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. 
      stepanov.aleksei@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20180712
PL  - United States
TA  - Bull Exp Biol Med
JT  - Bulletin of experimental biology and medicine
JID - 0372557
RN  - 0 (Receptors, TNF-Related Apoptosis-Inducing Ligand)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Recombinant Proteins)
RN  - 0 (TNF-Related Apoptosis-Inducing Ligand)
RN  - 0 (TNFRSF10B protein, human)
RN  - 0 (TNFSF10 protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Amino Acid Sequence
MH  - Apoptosis/*drug effects/genetics
MH  - Binding Sites
MH  - Cell Line, Tumor
MH  - Cloning, Molecular
MH  - Escherichia coli/genetics/metabolism
MH  - Gene Expression
MH  - *Gene Expression Regulation, Neoplastic
MH  - Genetic Vectors/chemistry/metabolism
MH  - Humans
MH  - Lymphocytes/*drug effects/metabolism/pathology
MH  - Models, Molecular
MH  - Mutation
MH  - Protein Binding
MH  - Protein Conformation, alpha-Helical
MH  - Protein Conformation, beta-Strand
MH  - Protein Interaction Domains and Motifs
MH  - Receptors, TNF-Related Apoptosis-Inducing Ligand/antagonists & 
      inhibitors/chemistry/*genetics/metabolism
MH  - Receptors, Tumor Necrosis Factor, Type I/chemistry/genetics/metabolism
MH  - Recombinant Proteins/chemistry/genetics/metabolism
MH  - Signal Transduction
MH  - TNF-Related Apoptosis-Inducing Ligand/chemistry/genetics/metabolism/pharmacology
MH  - Tumor Necrosis Factor-alpha/chemistry/*genetics/metabolism/pharmacology
OTO - NOTNLM
OT  - TNF
OT  - TRAIL
OT  - apoptosis
OT  - death receptor 5
EDAT- 2018/07/14 06:00
MHDA- 2019/06/25 06:00
CRDT- 2018/07/14 06:00
PHST- 2017/12/12 00:00 [received]
PHST- 2018/07/14 06:00 [pubmed]
PHST- 2019/06/25 06:00 [medline]
PHST- 2018/07/14 06:00 [entrez]
AID - 10.1007/s10517-018-4176-9 [pii]
AID - 10.1007/s10517-018-4176-9 [doi]
PST - ppublish
SO  - Bull Exp Biol Med. 2018 Jul;165(3):386-389. doi: 10.1007/s10517-018-4176-9. Epub 
      2018 Jul 12.