PMID- 30005188
OWN - NLM
STAT- MEDLINE
DCOM- 20190222
LR  - 20190222
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 119
DP  - 2018 Oct
TI  - Prenatal exposure to persistent organic pollutants and methylation of LINE-1 and 
      imprinted genes in placenta: A CHECK cohort study.
PG  - 398-406
LID - S0160-4120(18)30061-8 [pii]
LID - 10.1016/j.envint.2018.06.039 [doi]
AB  - Prenatal exposure to persistent organic pollutants (POPs) has been linked to 
      numerous adverse birth outcomes among newborn infants in many epidemiological 
      studies. Although epigenetic modifications have been suggested as possible 
      explanations for those associations, studies have rarely reported a relationship 
      between POP exposure during pregnancy and DNA methylation in the placenta. In the 
      present study, we investigated the association between prenatal exposure to 
      several POPs, including organochlorine pesticides (OCPs), polybrominated diphenyl 
      ethers (PBDEs), and polychlorinated biphenyls (PCBs), and methylation levels of 
      long interspersed element 1 (LINE-1), as well as imprinted genes in placental 
      DNAs among Korean mother-child pairs (N = 109). We assessed the association of 
      DNA methylation not only with each target POP (single-POP models) but also with 
      multiple POPs applying principal component analysis (multiple-POP models). 
      Potential associations between placental DNA methylation and birth outcomes of 
      newborn infants were also estimated. In single-POP models, significant 
      associations were detected between OCP measurements and placental DNA 
      methylation. Elevated concentrations of beta-hexachlorhexane (beta-HCH) in maternal 
      serum collected during delivery were significantly associated with a decrease in 
      methylation of LINE-1 in the placenta. Higher levels of 
      p,p'-dichlorodiphenyltrichloroethane (p,p'-DDT) in maternal serum were associated 
      with hypermethylation of insulin-like growth factor 2 (IGF2). In multiple-POP 
      models, a significant and positive association between DDTs and IGF2 methylation 
      was also observed. Placental LINE-1 methylation was inversely associated with 
      birth length. Our observations indicate that prenatal exposure to several POPs 
      including DDTs is associated with the changes in methylation of genes, including 
      major imprinted genes in the placenta. The consequences of these epigenetic 
      alterations in placenta during development deserve further investigation.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Kim, Sujin
AU  - Kim S
AD  - School of Public Health, Seoul National University, Seoul 08826, Republic of 
      Korea.
FAU - Cho, Yoon Hee
AU  - Cho YH
AD  - Center for Environmental Health Sciences, Department of Biomedical and 
      Pharmaceutical Sciences, The University of Montana, Missoula, MT 59812, USA.
FAU - Lee, Inae
AU  - Lee I
AD  - School of Public Health, Seoul National University, Seoul 08826, Republic of 
      Korea.
FAU - Kim, Wonji
AU  - Kim W
AD  - Interdisciplinary Program of Bioinformatics, Seoul National University, Seoul 
      08826, Republic of Korea.
FAU - Won, Sungho
AU  - Won S
AD  - School of Public Health, Seoul National University, Seoul 08826, Republic of 
      Korea.
FAU - Ku, Ja-Lok
AU  - Ku JL
AD  - Laboratory of Cell Biology, Cancer Research Institute, Seoul National University 
      College of Medicine, Seoul 03080, Republic of Korea; Department of Biomedical 
      Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of 
      Korea.
FAU - Moon, Hyo-Bang
AU  - Moon HB
AD  - Department of Marine Science and Convergence Engineering, Hanyang University, 
      Ansan 15588, Republic of Korea.
FAU - Park, Jeongim
AU  - Park J
AD  - College of Natural Sciences, Soonchunhyang University, Asan 31538, Republic of 
      Korea.
FAU - Kim, Sungkyoon
AU  - Kim S
AD  - School of Public Health, Seoul National University, Seoul 08826, Republic of 
      Korea.
FAU - Choi, Gyuyeon
AU  - Choi G
AD  - College of Medicine, Soonchunhyang University, Seoul 04401, Republic of Korea.
FAU - Choi, Kyungho
AU  - Choi K
AD  - School of Public Health, Seoul National University, Seoul 08826, Republic of 
      Korea. Electronic address: kyungho@snu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180710
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Halogenated)
SB  - IM
MH  - DNA Methylation/*genetics
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Humans
MH  - Hydrocarbons, Halogenated/*blood
MH  - Long Interspersed Nucleotide Elements/*genetics
MH  - Maternal Exposure/*statistics & numerical data
MH  - Placenta/chemistry
MH  - Pregnancy
OTO - NOTNLM
OT  - A multi-pollutant approach
OT  - Epigenetics
OT  - Fetal growth
OT  - Global methylation
OT  - Imprinted gene
OT  - Persistent organic pollutant
EDAT- 2018/07/14 06:00
MHDA- 2019/02/23 06:00
CRDT- 2018/07/14 06:00
PHST- 2018/01/11 00:00 [received]
PHST- 2018/06/28 00:00 [revised]
PHST- 2018/06/29 00:00 [accepted]
PHST- 2018/07/14 06:00 [pubmed]
PHST- 2019/02/23 06:00 [medline]
PHST- 2018/07/14 06:00 [entrez]
AID - S0160-4120(18)30061-8 [pii]
AID - 10.1016/j.envint.2018.06.039 [doi]
PST - ppublish
SO  - Environ Int. 2018 Oct;119:398-406. doi: 10.1016/j.envint.2018.06.039. Epub 2018 
      Jul 10.