PMID- 30006288
OWN - NLM
STAT- MEDLINE
DCOM- 20190212
LR  - 20190215
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 486
DP  - 2018 Nov
TI  - Anti-AChR, MuSK, and LRP4 antibodies coexistence: A rare and distinct subtype of 
      myasthenia gravis from Indian subcontinent.
PG  - 34-35
LID - S0009-8981(18)30347-4 [pii]
LID - 10.1016/j.cca.2018.07.011 [doi]
AB  - BACKGROUND: Myasthenia gravis is B-cell mediated autoimmune disease and is 
      associated with antibodies against the acetylcholine receptor (AChR), 
      muscle-specific kinase (MuSK) and lipoprotein-related protein 4 (LRP4) in the 
      postsynaptic membrane at the neuromuscular junction. There are few studies on the 
      concurrent presence of two positive antibodies in the sera of patients with 
      myasthenia gravis. CASE DESCRIPTION: A 32-year male admitted to the hospital with 
      progressive neuromuscular weakness. He was diagnosed with Myasthenia gravis 
      disorder mimicking Amyotrophic Lateral Sclerosis. We herein report a rare 
      co-existence of three antibodies (anti-AChR, MuSK, and LRP4 antibodies) in the 
      patient's serum. CONCLUSION: We present a detailed clinical and laboratory 
      analysis of the patient. This case report will emphasize the importance of 
      evaluating anti-MuSK and anti-LRP4 antibodies even in patients with anti-AChR 
      antibodies.
CI  - Copyright (c) 2018. Published by Elsevier B.V.
FAU - Bokoliya, Suresh C
AU  - Bokoliya SC
AD  - Department of Neuromicrobiology, National Institute of Mental Health and 
      Neurosciences, Hosur Road, Bangalore, 560029, India.
FAU - Kumar, Veeramani Preethish
AU  - Kumar VP
AD  - Department of Neurology and Clinical Neurosciences, National Institute of Mental 
      Health and Neurosciences, Hosur Road, Bangalore, 560029, India.
FAU - Nashi, Saraswati
AU  - Nashi S
AD  - Department of Neurology, National Institute of Mental Health and Neurosciences, 
      Hosur Road, Bangalore, 560029, India.
FAU - Polavarapu, Kiran
AU  - Polavarapu K
AD  - Department of Neurology and Clinical Neurosciences, National Institute of Mental 
      Health and Neurosciences, Hosur Road, Bangalore, 560029, India.
FAU - Nalini, Atchayaram
AU  - Nalini A
AD  - Department of Neurology, National Institute of Mental Health and Neurosciences, 
      Hosur Road, Bangalore, 560029, India.
FAU - Patil, Shripad A
AU  - Patil SA
AD  - Department of Neuromicrobiology, National Institute of Mental Health and 
      Neurosciences, Hosur Road, Bangalore, 560029, India. Electronic address: 
      shripadpatil@yahoo.com.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20180710
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (LDL-Receptor Related Proteins)
RN  - 0 (LRP4 protein, human)
RN  - 0 (Receptors, Cholinergic)
RN  - EC 2.7.10.1 (MUSK protein, human)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Adult
MH  - Humans
MH  - India
MH  - LDL-Receptor Related Proteins/*blood
MH  - Male
MH  - Myasthenia Gravis/*blood/diagnosis
MH  - Receptor Protein-Tyrosine Kinases/*blood/metabolism
MH  - Receptors, Cholinergic/*blood/metabolism
OTO - NOTNLM
OT  - AChR
OT  - Antibodies
OT  - LRP4
OT  - MuSK
OT  - Myasthenia gravis
EDAT- 2018/07/15 06:00
MHDA- 2019/02/13 06:00
CRDT- 2018/07/15 06:00
PHST- 2018/02/13 00:00 [received]
PHST- 2018/05/14 00:00 [revised]
PHST- 2018/07/09 00:00 [accepted]
PHST- 2018/07/15 06:00 [pubmed]
PHST- 2019/02/13 06:00 [medline]
PHST- 2018/07/15 06:00 [entrez]
AID - S0009-8981(18)30347-4 [pii]
AID - 10.1016/j.cca.2018.07.011 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2018 Nov;486:34-35. doi: 10.1016/j.cca.2018.07.011. Epub 2018 Jul 
      10.