PMID- 30007546
OWN - NLM
STAT- MEDLINE
DCOM- 20190327
LR  - 20190327
IS  - 1872-9142 (Electronic)
IS  - 0161-5890 (Linking)
VI  - 101
DP  - 2018 Sep
TI  - Dendritic cells in sepsis: Potential immunoregulatory cells with therapeutic 
      potential.
PG  - 615-626
LID - S0161-5890(18)30534-0 [pii]
LID - 10.1016/j.molimm.2018.07.007 [doi]
AB  - Sepsis is a disease of dysfunctional immune response against the pathogen causing 
      a profound immune-mediated damage to the vital organs and death of the patient in 
      most cases. However, when sepsis is described much attention is given to 
      monocytes/macrophages, complement system, neutrophils, cytokine storm, and T 
      cells. Dendritic cells (DCs) get less attention in this scenario despite 
      comprising the major immune cell population. Therefore the present review is 
      designed to highlight the importance of DCs in the pathogenesis of sepsis, 
      sepsis-associated immunosuppression, and organ damage. The article starts with an 
      introduction of sepsis as a major medical problem needing an urgent therapeutic 
      targeting. Thereafter it provides a brief information regarding classical and 
      plasmacytoid DCs and their role in the maintenance of immune homeostasis. The 
      subsequent sections describe the role of DCs in the immunopathogenesis of sepsis 
      via immunoregulation, impact of sepsis on DCs including their immunometabolic 
      changes, and their therapeutic targeting during sepsis.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Kumar, V
AU  - Kumar V
AD  - Children's Health Queensland Clinical Unit, School of Clinical Medicine, Mater 
      Research, Faculty of Medicine, University of Queensland, ST Lucia, Brisbane, 
      Queensland 4078, Australia; School of Biomedical Sciences, Faculty of Medicine, 
      University of Queensland, ST Lucia, Brisbane, Queensland 4078, Australia. 
      Electronic address: v.kumar3@uq.edu.au.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180713
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immunity
MH  - Models, Biological
MH  - Sepsis/*immunology
OTO - NOTNLM
OT  - Dendritic cells
OT  - Immunometabolism
OT  - Immunosuppression
OT  - Sepsis
OT  - cDCs
OT  - pDCs
EDAT- 2018/07/17 06:00
MHDA- 2019/03/28 06:00
CRDT- 2018/07/16 06:00
PHST- 2018/04/22 00:00 [received]
PHST- 2018/07/01 00:00 [revised]
PHST- 2018/07/02 00:00 [accepted]
PHST- 2018/07/17 06:00 [pubmed]
PHST- 2019/03/28 06:00 [medline]
PHST- 2018/07/16 06:00 [entrez]
AID - S0161-5890(18)30534-0 [pii]
AID - 10.1016/j.molimm.2018.07.007 [doi]
PST - ppublish
SO  - Mol Immunol. 2018 Sep;101:615-626. doi: 10.1016/j.molimm.2018.07.007. Epub 2018 
      Jul 13.