PMID- 30007609
OWN - NLM
STAT- MEDLINE
DCOM- 20181105
LR  - 20181202
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 197
DP  - 2018 Oct 1
TI  - Fabrication and biocompatibility of agarose acetate nanofibrous membrane by 
      electrospinning.
PG  - 237-245
LID - S0144-8617(18)30650-7 [pii]
LID - 10.1016/j.carbpol.2018.06.004 [doi]
AB  - In the present paper, agarose acetate (AGA) nanofibrous membranes containing 
      different weight percentages of beta-tricalcium phosphate (beta-TCP) were successfully 
      developed through electrospinning. The fibers in the nanofibrous membranes had a 
      rough surface due to the beta-TCP particles which were uniformly dispersed within or 
      on the surface of AGA fibers. Rat-bone marrow-derived mesenchymal stem cells 
      (rBMSCs) were cultured on the AGA based nanofibrous membranes while showed a good 
      adhesion and proliferation. It was found that more rBMSCs were differentiated to 
      osteoblast-like cells on the beta-TCP containing nanofibrous membranes compared with 
      the single AGA membrane, and more alkaline phosphatase (ALP) and mineralized 
      matrix could be detected when rBMSCs were cultured on the beta-TCP containing 
      nanofibrous membranes. The nanofibrous membranes were implanted into 
      Sprague-Dawley (SD) rats for biocompatibility test. Gross examination and 
      histological analysis of the AGA based nanofibrous membranes results showed that 
      there was less inflammatory response. All of experimental results suggested that 
      the AGA based nanofibrous membranes had the great potential application in bone 
      tissue engineering.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Xu, Zunkai
AU  - Xu Z
AD  - Biomedical Engineering Institute, Jinan University, Guangzhou 510632, China.
FAU - Zhao, Ruifang
AU  - Zhao R
AD  - Biomedical Engineering Institute, Jinan University, Guangzhou 510632, China.
FAU - Huang, Xiuying
AU  - Huang X
AD  - Biomedical Engineering Institute, Jinan University, Guangzhou 510632, China.
FAU - Wang, Xiaoying
AU  - Wang X
AD  - Biomedical Engineering Institute, Jinan University, Guangzhou 510632, China.
FAU - Tang, Shunqing
AU  - Tang S
AD  - Biomedical Engineering Institute, Jinan University, Guangzhou 510632, China. 
      Electronic address: tshunqt@jnu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20180602
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
RN  - 0 (Acetates)
RN  - 0 (Biocompatible Materials)
RN  - 0 (Calcium Phosphates)
RN  - 0 (beta-tricalcium phosphate)
RN  - 9012-36-6 (Sepharose)
SB  - IM
MH  - Acetates/*chemistry/pharmacology
MH  - Animals
MH  - Biocompatible Materials/*chemical synthesis/chemistry/pharmacology
MH  - Calcium Phosphates/chemistry
MH  - Cell Proliferation/drug effects
MH  - Cells, Cultured
MH  - Mesenchymal Stem Cells/drug effects
MH  - Nanofibers/*chemistry
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sepharose/*chemistry/pharmacology
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Thermogravimetry
MH  - Tissue Engineering
MH  - Wettability
MH  - X-Ray Diffraction
OTO - NOTNLM
OT  - Agarose acetate
OT  - Bone tissue engineering
OT  - Nanofibrous membrane
OT  - Osteogenic differentiation
OT  - beta-TCP
EDAT- 2018/07/17 06:00
MHDA- 2018/11/06 06:00
CRDT- 2018/07/16 06:00
PHST- 2018/02/05 00:00 [received]
PHST- 2018/05/26 00:00 [revised]
PHST- 2018/06/02 00:00 [accepted]
PHST- 2018/07/16 06:00 [entrez]
PHST- 2018/07/17 06:00 [pubmed]
PHST- 2018/11/06 06:00 [medline]
AID - S0144-8617(18)30650-7 [pii]
AID - 10.1016/j.carbpol.2018.06.004 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2018 Oct 1;197:237-245. doi: 10.1016/j.carbpol.2018.06.004. Epub 
      2018 Jun 2.