PMID- 30007869
OWN - NLM
STAT- MEDLINE
DCOM- 20191028
LR  - 20191028
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 202
DP  - 2018 Dec
TI  - Stability in basic self-disturbances and diagnosis in a first treated psychosis: 
      A seven year follow-up study.
PG  - 274-280
LID - S0920-9964(18)30426-2 [pii]
LID - 10.1016/j.schres.2018.07.011 [doi]
AB  - BACKGROUND: Basic self-disturbances (BSDs) are considered core features of 
      schizophrenia spectrum disorders, and are present in the prodromal, early 
      psychotic and chronic phases. Considerable levels of BSDs are also present at 
      first treatment in some patients with psychotic disorders outside the 
      schizophrenia spectrum. There is limited knowledge about the stability of 
      self-disturbances over time. AIM: To explore the stability of BSDs in a 
      seven-year follow-up of first treatment patients, and the association between 
      baseline levels and changes in BSDs and diagnostic changes at follow-up. METHOD: 
      Longitudinal study of 56 patients (35 schizophrenia and 21 non-schizophrenia) 
      recruited at their first treatment for a psychotic disorder. BSDs were assessed 
      using the Examination of Anomalous Self-Experience (EASE), while diagnostic 
      categories, clinical symptom severity, and functioning were assessed with 
      standard clinical instruments. RESULTS: The schizophrenia group had significantly 
      lower levels of BSDs at follow-up compared to baseline. The EASE domain 
      "Cognition and stream of consciousness" was the most stable. There were no 
      diagnostic changes into or out of schizophrenia spectrum. Patients with 
      schizophrenia had significantly higher levels of BSDs both at baseline and at 
      follow up than patients with psychotic disorders outside the schizophrenia 
      spectrum, who showed stable low levels. CONCLUSION: We found a decrease and thus 
      less stability in BSDs in schizophrenia than expected. This might indicate that 
      BSDs tent to weaken over time, and that unknown individual characteristics may 
      influence the development of BSDs. Diagnostic stability from baseline to 
      follow-up may be due to long DUP before service entry.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Svendsen, Ingrid Hartveit
AU  - Svendsen IH
AD  - Innlandet Hospital Trust, Department of Acute Psychiatry and Psychosis Treatment, 
      Presteseter 1, 2840 Reinsvoll, Norway; University of Oslo, Faculty of Medicine, 
      P. B. 1018, Blindern, 0315 Oslo, Norway. Electronic address: 
      ingridhartveit.svendsen@sykehuset-innlandet.no.
FAU - Oie, Merete G
AU  - Oie MG
AD  - Department of Psychology, University of Oslo, Pb 1094, Blindern, Norway; Division 
      of Research, Innlandet Hospital Trust, Norway. Electronic address: 
      m.g.oie@psykologi.uio.no.
FAU - Moller, Paul
AU  - Moller P
AD  - Vestre Viken Hospital Trust, Division of Mental Health and Addiction, Department 
      of Mental Health Research and Development, Norway. Electronic address: 
      Paul.Moller@vestreviken.no.
FAU - Nelson, Barnaby
AU  - Nelson B
AD  - Orygen Youth Health, Centre for Youth Mental Health, University of Melbourne, 35 
      Poplar Rd (Locked Bag 10), Parkville, Victoria 3052, Australia. Electronic 
      address: nelsonb@unimelb.edu.au.
FAU - Melle, Ingrid
AU  - Melle I
AD  - NORMENT KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, 
      University of Oslo, Postal adr, P.O. Box 1039, Blindern, 0315 Oslo, Norway; 
      Division of Mental Health and Addiction, Oslo University Hospital, Postal adr, 
      P.O. Box 1039, Blindern, 0315 Oslo, Norway. Electronic address: 
      ingrid.melle@medisin.uio.no.
FAU - Haug, Elisabeth
AU  - Haug E
AD  - Innlandet Hospital Trust, Department of Acute Psychiatry and Psychosis Treatment, 
      Presteseter 1, 2840 Reinsvoll, Norway. Electronic address: 
      elisabeth.haug@sykehuset-innlandet.no.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180711
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adult
MH  - Bipolar Disorder/diagnosis/psychology
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/*diagnosis/psychology
MH  - Schizophrenia/*diagnosis
MH  - Schizophrenic Psychology
MH  - Young Adult
OTO - NOTNLM
OT  - Bipolar disorder
OT  - Early intervention
OT  - Examination of anomalous self-experience
OT  - Phenomenology
OT  - Schizophrenia
EDAT- 2018/07/17 06:00
MHDA- 2019/10/29 06:00
CRDT- 2018/07/16 06:00
PHST- 2017/12/08 00:00 [received]
PHST- 2018/06/17 00:00 [revised]
PHST- 2018/07/01 00:00 [accepted]
PHST- 2018/07/17 06:00 [pubmed]
PHST- 2019/10/29 06:00 [medline]
PHST- 2018/07/16 06:00 [entrez]
AID - S0920-9964(18)30426-2 [pii]
AID - 10.1016/j.schres.2018.07.011 [doi]
PST - ppublish
SO  - Schizophr Res. 2018 Dec;202:274-280. doi: 10.1016/j.schres.2018.07.011. Epub 2018 
      Jul 11.