PMID- 30008280
OWN - NLM
STAT- MEDLINE
DCOM- 20190326
LR  - 20190326
IS  - 1601-5215 (Electronic)
IS  - 0924-2708 (Linking)
VI  - 30
IP  - 6
DP  - 2018 Dec
TI  - Mediator effects of parameters of inflammation and neurogenesis from a N-acetyl 
      cysteine clinical-trial for bipolar depression.
PG  - 334-341
LID - 10.1017/neu.2018.13 [doi]
AB  - OBJECTIVE: This study aimed to explore effects of adjunctive treatment with 
      N-acetyl cysteine (NAC) on markers of inflammation and neurogenesis in bipolar 
      depression. METHODS: This is a secondary analysis of a placebo-controlled 
      randomised trial. Serum samples were collected at baseline, week 8, and week 32 
      of the open-label and maintenance phases of the clinical trial to determine 
      changes in interleukin (IL)-6, IL-8, IL-10, tumour necrosis factor-alpha (TNF-alpha), 
      C-reactive protein (CRP) and brain-derived neurotrophic factor (BDNF) following 
      adjunctive NAC treatment, and to explore mediation and moderator effects of the 
      listed markers. RESULTS: Levels of brain-derived neurotrophic factor (BDNF), 
      tumour necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), interleukins (IL) -6, 
      8, or 10 were not significantly changed during the course of the trial or 
      specifically in the open-label and maintenance phases. There were no mediation or 
      moderation effects of the biological factors on the clinical parameters. 
      CONCLUSION: The results suggest that these particular biological parameters may 
      not be directly involved in the therapeutic mechanism of action of adjunctive NAC 
      in bipolar depression.
FAU - Panizzutti, Bruna
AU  - Panizzutti B
AD  - 1Laboratory of Molecular Psychiatry,Hospital de Clinicas de Porto Alegre (HCPA) 
      and Programa de Pos-graduacao em Psiquiatria e Ciencias do 
      Comportamento,Faculdade de Medicina,Universidade Federal do Rio Grande do Sul 
      (UFRGS),Porto Alegre,Brazil.
FAU - Bortolasci, Chiara
AU  - Bortolasci C
AD  - 2Graduation Program in Health Sciences,State University of Londrina 
      (UEL),Londrina,Brazil.
FAU - Hasebe, Kyoko
AU  - Hasebe K
AD  - 3Deakin University,School of Medicine,Centre for Molecular and Medical 
      Research,Geelong,Australia.
FAU - Kidnapillai, Srisaiyini
AU  - Kidnapillai S
AD  - 3Deakin University,School of Medicine,Centre for Molecular and Medical 
      Research,Geelong,Australia.
FAU - Gray, Laura
AU  - Gray L
AD  - 3Deakin University,School of Medicine,Centre for Molecular and Medical 
      Research,Geelong,Australia.
FAU - Walder, Ken
AU  - Walder K
AD  - 3Deakin University,School of Medicine,Centre for Molecular and Medical 
      Research,Geelong,Australia.
FAU - Berk, Michael
AU  - Berk M
AD  - 4Deakin University,School of Medicine,IMPACT Strategic Research Centre,Barwon 
      Health,Geelong,Australia.
FAU - Mohebbi, Mohammadreza
AU  - Mohebbi M
AD  - 8Deakin University,Biostatistics Unit,Faculty of Health,Geelong,Australia.
FAU - Dodd, Seetal
AU  - Dodd S
AD  - 4Deakin University,School of Medicine,IMPACT Strategic Research Centre,Barwon 
      Health,Geelong,Australia.
FAU - Gama, Clarissa
AU  - Gama C
AD  - 1Laboratory of Molecular Psychiatry,Hospital de Clinicas de Porto Alegre (HCPA) 
      and Programa de Pos-graduacao em Psiquiatria e Ciencias do 
      Comportamento,Faculdade de Medicina,Universidade Federal do Rio Grande do Sul 
      (UFRGS),Porto Alegre,Brazil.
FAU - Magalhaes, Pedro V
AU  - Magalhaes PV
AD  - 1Laboratory of Molecular Psychiatry,Hospital de Clinicas de Porto Alegre (HCPA) 
      and Programa de Pos-graduacao em Psiquiatria e Ciencias do 
      Comportamento,Faculdade de Medicina,Universidade Federal do Rio Grande do Sul 
      (UFRGS),Porto Alegre,Brazil.
FAU - Cotton, Susan M
AU  - Cotton SM
AD  - 7Orygen Centre for Youth Mental Health,University of 
      Melbourne,Parkville,Australia.
FAU - Kapczinski, Flavio
AU  - Kapczinski F
AD  - 1Laboratory of Molecular Psychiatry,Hospital de Clinicas de Porto Alegre (HCPA) 
      and Programa de Pos-graduacao em Psiquiatria e Ciencias do 
      Comportamento,Faculdade de Medicina,Universidade Federal do Rio Grande do Sul 
      (UFRGS),Porto Alegre,Brazil.
FAU - Bush, Ashley I
AU  - Bush AI
AD  - 5Department of Psychiatry,The University of Melbourne,Parkville,Australia.
FAU - Malhi, Gin S
AU  - Malhi GS
AD  - 10Academic Department of Psychiatry,Northern Sydney Local Health District,St 
      Leonards,NSW,Australia.
FAU - Dean, Olivia M
AU  - Dean OM
AD  - 4Deakin University,School of Medicine,IMPACT Strategic Research Centre,Barwon 
      Health,Geelong,Australia.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20180716
PL  - England
TA  - Acta Neuropsychiatr
JT  - Acta neuropsychiatrica
JID - 9612501
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Interleukins)
RN  - 0 (TNF protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetylcysteine/*therapeutic use
MH  - Adult
MH  - Aged
MH  - Bipolar Disorder/*blood/complications/*drug therapy
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - C-Reactive Protein/metabolism
MH  - Encephalitis/*blood/complications
MH  - Female
MH  - Humans
MH  - Interleukins/blood
MH  - Male
MH  - Middle Aged
MH  - *Neurogenesis
MH  - Treatment Outcome
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Young Adult
OTO - NOTNLM
OT  - N-acetyl cysteine
OT  - biomarkers
OT  - bipolar disorder
OT  - clinical trial
OT  - depression
EDAT- 2018/07/17 06:00
MHDA- 2019/03/27 06:00
CRDT- 2018/07/17 06:00
PHST- 2018/07/17 06:00 [pubmed]
PHST- 2019/03/27 06:00 [medline]
PHST- 2018/07/17 06:00 [entrez]
AID - S0924270818000133 [pii]
AID - 10.1017/neu.2018.13 [doi]
PST - ppublish
SO  - Acta Neuropsychiatr. 2018 Dec;30(6):334-341. doi: 10.1017/neu.2018.13. Epub 2018 
      Jul 16.