PMID- 30008380 OWN - NLM STAT- MEDLINE DCOM- 20190220 LR - 20190320 IS - 1872-7972 (Electronic) IS - 0304-3940 (Linking) VI - 684 DP - 2018 Sep 25 TI - The effect of bilateral low-frequency rTMS over dorsolateral prefrontal cortex on serum brain-derived neurotropic factor and serotonin in patients with generalized anxiety disorder. PG - 67-71 LID - S0304-3940(18)30477-4 [pii] LID - 10.1016/j.neulet.2018.07.008 [doi] AB - To investigate the effect of bilateral low-frequency repetitive transcranial magnetic stimulation (rTMS) over dorsolateral prefrontal cortex on serum brain-derived neurotropic factor (BDNF) and serotonin (5-HT) in patients with generalized anxiety disorders (GAD). As compared with before treatment, the HARS score in patients markedly decreased after treatment, and the levels of serum BDNF and 5-HT were significantly higher. Pearson correlation analysis revealed that the increase in the level of serum 5-HT was positively associated with the increase of the level of serum BDNF, and the change of anxiety score was negatively associated with the change of the level of serum BDNF and 5-HT. The results suggested that alleviation of GAD by bilateral low-frequency rTMS may be involved in the increase of the level of BDNF and the release of 5-HT in the brain. CI - Copyright (c) 2018 Elsevier B.V. All rights reserved. FAU - Lu, Rulan AU - Lu R AD - Laboratory of Neurological Disease, Department of Neurology, Changzhou No. 2 People's Hospital, The Affiliated Hospital of Nanjing Medical Univeristy, Changzhou, Jiangsu, 213003, China. FAU - Zhang, Chengliang AU - Zhang C AD - Laboratory of Neurological Disease, Department of Neurology, Changzhou No. 2 People's Hospital, The Affiliated Hospital of Nanjing Medical Univeristy, Changzhou, Jiangsu, 213003, China. FAU - Liu, Yanyan AU - Liu Y AD - Laboratory of Neurological Disease, Department of Neurology, Changzhou No. 2 People's Hospital, The Affiliated Hospital of Nanjing Medical Univeristy, Changzhou, Jiangsu, 213003, China. FAU - Wang, Linxiao AU - Wang L AD - Laboratory of Neurological Disease, Department of Neurology, Changzhou No. 2 People's Hospital, The Affiliated Hospital of Nanjing Medical Univeristy, Changzhou, Jiangsu, 213003, China. FAU - Chen, Xia AU - Chen X AD - Laboratory of Neurological Disease, Department of Neurology, Changzhou No. 2 People's Hospital, The Affiliated Hospital of Nanjing Medical Univeristy, Changzhou, Jiangsu, 213003, China. FAU - Zhou, Xianju AU - Zhou X AD - Laboratory of Neurological Disease, Department of Neurology, Changzhou No. 2 People's Hospital, The Affiliated Hospital of Nanjing Medical Univeristy, Changzhou, Jiangsu, 213003, China. Electronic address: xianju_zhou@yahoo.com. LA - eng PT - Clinical Trial PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180706 PL - Ireland TA - Neurosci Lett JT - Neuroscience letters JID - 7600130 RN - 0 (Biomarkers) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 333DO1RDJY (Serotonin) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Adult MH - Aged MH - Anxiety Disorders/*blood/diagnosis/*therapy MH - Biomarkers/blood MH - Brain-Derived Neurotrophic Factor/*blood MH - Female MH - Humans MH - Male MH - Middle Aged MH - Prefrontal Cortex/*metabolism MH - Serotonin/*blood MH - Transcranial Magnetic Stimulation/*methods MH - Treatment Outcome OTO - NOTNLM OT - Brain-derived neurotropic factor OT - Generalized anxiety disorder OT - Repetitive transcranial magnetic stimulation OT - Serotonin EDAT- 2018/07/17 06:00 MHDA- 2019/03/21 06:00 CRDT- 2018/07/17 06:00 PHST- 2017/11/30 00:00 [received] PHST- 2018/06/22 00:00 [revised] PHST- 2018/07/05 00:00 [accepted] PHST- 2018/07/17 06:00 [pubmed] PHST- 2019/03/21 06:00 [medline] PHST- 2018/07/17 06:00 [entrez] AID - S0304-3940(18)30477-4 [pii] AID - 10.1016/j.neulet.2018.07.008 [doi] PST - ppublish SO - Neurosci Lett. 2018 Sep 25;684:67-71. doi: 10.1016/j.neulet.2018.07.008. Epub 2018 Jul 6.