PMID- 30008596
OWN - NLM
STAT- MEDLINE
DCOM- 20190121
LR  - 20230926
IS  - 1449-1907 (Electronic)
IS  - 1449-1907 (Linking)
VI  - 15
IP  - 9
DP  - 2018
TI  - Chewing during prenatal stress prevents prenatal stress-induced suppression of 
      neurogenesis, anxiety-like behavior and learning deficits in mouse offspring.
PG  - 849-858
LID - 10.7150/ijms.25281 [doi]
AB  - Prenatal stress (PS) induces learning deficits and anxiety-like behavior in mouse 
      pups by increasing corticosterone levels in the dam. We examined the effects of 
      maternal chewing during PS on arginine vasopressin (AVP) mRNA expression in the 
      dams and on neurogenesis, brain-derived neurotrophic factor (BDNF) mRNA 
      expression, learning deficits and anxiety-like behavior in the offspring. Mice 
      were divided into control, stress and stress/chewing groups. Pregnant mice were 
      exposed to restraint stress beginning on day 12 of pregnancy and continuing until 
      delivery. Mice in the stress/chewing group were given a wooden stick to chew 
      during restraint stress. PS significantly increased AVP mRNA expression in the 
      paraventricular nucleus (PVN) of the hypothalamus in the dams. PS also impaired 
      learning ability, suppressed neurogenesis and BDNF mRNA expression in the 
      hippocampus, and induced anxiety-like behavior in the offspring. Chewing during 
      PS prevented the PS-induced increase in AVP mRNA expression of the PVN in the 
      dams. Chewing during PS significantly attenuated the PS-induced learning 
      deficits, anxiety-like behavior, and suppression of neurogenesis and BDNF mRNA 
      expression in the hippocampus of the offspring. Chewing during PS prevented the 
      increase in plasma corticosterone in the dam by inhibiting the 
      hypothalamic-pituitary-adrenal axis activity, and attenuated the attenuated the 
      PS-induced suppression of neurogenesis and BDNF expression in the hippocampus of 
      the pups, thereby ameliorating the PS-induced learning deficits and anxiety-like 
      behavior. Chewing during PS is an effective stress-coping method for the dam to 
      prevent PS-induced deficits in learning ability and anxiety-like behavior in the 
      offspring.
FAU - Kubo, Kin-Ya
AU  - Kubo KY
AD  - Graduate School of Human Life Science, Nagoya Women's University, 3-40 
      Shioji-cho, Mizuho-ku, Nagoya, Aichi, 467-8610, Japan.
FAU - Kotachi, Mika
AU  - Kotachi M
AD  - Departments of 2 Pediatric Dentistry, Asahi University School of Dentistry, 1851 
      Hozumi, Mizuho, Gifu, 501-0296, Japan.
FAU - Suzuki, Ayumi
AU  - Suzuki A
AD  - Departments of 2 Pediatric Dentistry, Asahi University School of Dentistry, 1851 
      Hozumi, Mizuho, Gifu, 501-0296, Japan.
FAU - Iinuma, Mitsuo
AU  - Iinuma M
AD  - Departments of 2 Pediatric Dentistry, Asahi University School of Dentistry, 1851 
      Hozumi, Mizuho, Gifu, 501-0296, Japan.
FAU - Azuma, Kagaku
AU  - Azuma K
AD  - Department of Anatomy, School of Medicine, University of Occupational and 
      Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyusyu, 807-8555, Japan.
LA  - eng
PT  - Journal Article
DEP - 20180526
PL  - Australia
TA  - Int J Med Sci
JT  - International journal of medical sciences
JID - 101213954
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Anxiety
MH  - Behavior, Animal
MH  - Corticosterone
MH  - Female
MH  - Hippocampus
MH  - Hypothalamo-Hypophyseal System/*physiology
MH  - Male
MH  - *Mastication
MH  - Mice
MH  - Neurogenesis
MH  - Pituitary-Adrenal System/*physiology
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - *Stress, Psychological
PMC - PMC6036092
OTO - NOTNLM
OT  - Anxiety-like behavior
OT  - BDNF
OT  - Chewing
OT  - Learning ability
OT  - Neurogenesis
OT  - Prenatal stress
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2018/07/17 06:00
MHDA- 2019/01/22 06:00
PMCR- 2018/01/01
CRDT- 2018/07/17 06:00
PHST- 2018/02/01 00:00 [received]
PHST- 2018/04/30 00:00 [accepted]
PHST- 2018/07/17 06:00 [entrez]
PHST- 2018/07/17 06:00 [pubmed]
PHST- 2019/01/22 06:00 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - ijmsv15p0849 [pii]
AID - 10.7150/ijms.25281 [doi]
PST - epublish
SO  - Int J Med Sci. 2018 May 26;15(9):849-858. doi: 10.7150/ijms.25281. eCollection 
      2018.