PMID- 30008602
OWN - NLM
STAT- MEDLINE
DCOM- 20190121
LR  - 20190121
IS  - 1449-1907 (Electronic)
IS  - 1449-1907 (Linking)
VI  - 15
IP  - 9
DP  - 2018
TI  - Assessment of a combination of Serum Proteins as potential biomarkers to 
      clinically predict Schizophrenia.
PG  - 900-906
LID - 10.7150/ijms.24346 [doi]
AB  - Schizophrenia (SZ) is a devastating psychiatric disorder. Validation of potential 
      serum biomarkers during first-episode psychosis (FEP) is especially helpful to 
      understand the onset and prognosis of this disorder. To address this question, we 
      examined multiple blood biomarkers and assessed the efficacy to diagnose SZ. The 
      expression levels of Neuregulin1 (NRG1), ErbB4, brain-derived neurotrophic factor 
      (BDNF), DNA methyltransferases 1 (DNMT1) and ten-eleven translocation 1 (TET1) 
      proteins in peripheral blood of 53 FEP patients and 57 healthy controls were 
      determined by enzyme-linked immunosorbent assay (ELISA). Multivariable logistic 
      regression including biomarker concentration as covariates was used to predict 
      SZ. Differentiating performance of these five serum protein levels was analyzed 
      by Receiver Operating Characteristic (ROC) curve analysis. We found that patients 
      with SZ present a higher concentration of DNMT1, and TET1 in peripheral blood, 
      but a lower concentration of NRG1, ErbB4 and BDNF than controls. Multivariable 
      logistic regression showed that ErbB4, BDNF and TET1 were independent predictors 
      of SZ, and when combined, provided high diagnostic accuracy for SZ. Together, our 
      findings highlight that altered expression of NRG1, ErbB4, BDNF, DNMT1 and TET1 
      are involved in schizophrenia development and they may serve as potential 
      biomarkers for the diagnosis of the schizophrenia. Therefore, our study provides 
      evidence that combination of ErbB4, BDNF and TET1 biomarkers could greatly 
      improve the diagnostic performance.
FAU - Li, Cunyan
AU  - Li C
AD  - Department of Laboratory Medicine, Hunan Provincial People's Hospital, The first 
      affiliated hospital of Hunan Normal University, Changsha, 410005, Hunan, China.
FAU - Tao, Huai
AU  - Tao H
AD  - Department of Biochemistry and Molecular Biology, Hunan University of Chinese 
      Medicine, Changsha 410208, Hunan, China.
FAU - Yang, Xiudeng
AU  - Yang X
AD  - Department of Laboratory Medicine, The Second Xiangya Hospital, Central South 
      University, Changsha 410011, Hunan, China.
FAU - Zhang, Xianghui
AU  - Zhang X
AD  - Department of Psychiatry, The Second Xiangya Hospital, Central South University, 
      Changsha, Hunan 410011, China; Mental Health Institute of Central South 
      University & Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, 
      China; China National Clinical Research Center on Mental Disorders (Xiangya) & 
      China National Technology Institute on Mental Disorders, China.
FAU - Liu, Yong
AU  - Liu Y
AD  - Department of Psychiatry, The Second Xiangya Hospital, Central South University, 
      Changsha, Hunan 410011, China; Mental Health Institute of Central South 
      University & Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, 
      China; China National Clinical Research Center on Mental Disorders (Xiangya) & 
      China National Technology Institute on Mental Disorders, China.
FAU - Tang, Yamei
AU  - Tang Y
AD  - Department of Laboratory Medicine, The Second Xiangya Hospital, Central South 
      University, Changsha 410011, Hunan, China.
FAU - Tang, Aiguo
AU  - Tang A
AD  - Department of Laboratory Medicine, The Second Xiangya Hospital, Central South 
      University, Changsha 410011, Hunan, China.
LA  - eng
PT  - Journal Article
DEP - 20180604
PL  - Australia
TA  - Int J Med Sci
JT  - International journal of medical sciences
JID - 101213954
RN  - 0 (Biomarkers)
RN  - 0 (Blood Proteins)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Proto-Oncogene Proteins)
RN  - EC 1.- (Mixed Function Oxygenases)
RN  - EC 1.- (TET1 protein, human)
RN  - EC 2.7.10.1 (ERBB4 protein, human)
RN  - EC 2.7.10.1 (Receptor, ErbB-4)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/*blood
MH  - Blood Proteins
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Case-Control Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Mixed Function Oxygenases/blood
MH  - Proto-Oncogene Proteins/blood
MH  - Receptor, ErbB-4/blood
MH  - Schizophrenia/blood/*diagnosis
MH  - Young Adult
PMC - PMC6036096
OTO - NOTNLM
OT  - BDNF
OT  - DNMT1
OT  - ErbB4
OT  - NRG1
OT  - Schizophrenia
OT  - TET1
OT  - biomarker
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2018/07/17 06:00
MHDA- 2019/01/22 06:00
PMCR- 2018/01/01
CRDT- 2018/07/17 06:00
PHST- 2017/12/13 00:00 [received]
PHST- 2018/04/27 00:00 [accepted]
PHST- 2018/07/17 06:00 [entrez]
PHST- 2018/07/17 06:00 [pubmed]
PHST- 2019/01/22 06:00 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - ijmsv15p0900 [pii]
AID - 10.7150/ijms.24346 [doi]
PST - epublish
SO  - Int J Med Sci. 2018 Jun 4;15(9):900-906. doi: 10.7150/ijms.24346. eCollection 
      2018.