PMID- 30009537
OWN - NLM
STAT- Publisher
LR  - 20240227
IS  - 2059-2310 (Electronic)
IS  - 2059-2302 (Linking)
DP  - 2018 Jul 16
TI  - Extended HLA-G haplotypes in patients with age-related macular degeneration.
LID - 10.1111/tan.13340 [doi]
AB  - The study aims to determine if genetic polymorphisms in the human leukocyte 
      antigen (HLA)-G gene are associated with age-related macular degeneration (AMD). 
      HLA-G is important for immunological tolerance, and it is also known to have 
      angiogenic effects. Polymorphisms in the 5'-upstream regulatory region (URR) and 
      3'-untranslated region (UTR) of HLA-G have been associated with a number of 
      diseases, especially with respect to a 14 bp insertion/deletion (ins/del) 
      polymorphism in the 3'UTR. Full gene sequencing was performed on a cohort of 146 
      AMD patients and 63 healthy controls aged 60 years or older and HLA-G haplotypes 
      were determined. Analyses were performed on a publicly available gene expression 
      dataset from the NCBI GEO database (accession number GSE29801) from which 
      expression data for HLA-G, -C and -A were extracted. Analysis of the GEO dataset 
      showed that both HLA-G and -C was expressed in the back of the eye and that 
      expression was upregulated in the macular area of AMD. No differences were 
      observed between patients and controls when analysing the distribution of 
      haplotypes in the HLA-G promoter, coding region, 3'UTR or the 14 bp ins/del 
      polymorphism of the 3'UTR. The increased expression of HLA-G in the macula of AMD 
      patients indicates a role of HLA-G in the micro environment as part of the AMD 
      pathogenesis. This is supported by the expression of HLA-C, which has previously 
      been shown to play a role in AMD. The HLA-G haplotype distribution did not 
      display any differences between AMD patients and controls. This article is 
      protected by copyright. All rights reserved.
CI  - This article is protected by copyright. All rights reserved.
FAU - Svendsen, Signe Goul
AU  - Svendsen SG
AD  - Department of Immunology and Microbiology, University of Copenhagen, Denmark.
FAU - Nilsson, Line Lynge
AU  - Nilsson LL
AD  - Centre for Immune Regulation and Reproductive Immunology (CIRRI), Department of 
      Clinical Biochemistry, Zealand University Hospital, Denmark.
AD  - Department of Clinical Medicine, Faculty of Health Sciences, University of 
      Copenhagen.
FAU - Djurisic, Snezana
AU  - Djurisic S
AD  - Centre for Immune Regulation and Reproductive Immunology (CIRRI), Department of 
      Clinical Biochemistry, Zealand University Hospital, Denmark.
AD  - Department of Clinical Medicine, Faculty of Health Sciences, University of 
      Copenhagen.
FAU - Funck, Tina
AU  - Funck T
AD  - Centre for Immune Regulation and Reproductive Immunology (CIRRI), Department of 
      Clinical Biochemistry, Zealand University Hospital, Denmark.
AD  - Department of Clinical Medicine, Faculty of Health Sciences, University of 
      Copenhagen.
FAU - Wu, Ching-Lien
AU  - Wu CL
AD  - Hemato-Immunology Research Department, CEA, Hospital Saint Louis, Paris.
FAU - Faber, Carsten
AU  - Faber C
AD  - Department of Immunology and Microbiology, University of Copenhagen, Denmark.
AD  - Department of Ophthalmology, Rigshospitalet, Glostrup, Denmark.
FAU - Falk, Mads Kruger
AU  - Falk MK
AD  - Department of Ophthalmology, Rigshospitalet, Glostrup, Denmark.
AD  - Clinical Eye Research Unit, Department of Ophthalmology, Zealand University 
      Hospital, Roskilde, Denmark.
FAU - Singh, Amardeep
AU  - Singh A
AD  - Clinical Eye Research Unit, Department of Ophthalmology, Zealand University 
      Hospital, Roskilde, Denmark.
AD  - Dept. of Ophthalmology, Skane University Hospital & Lund University, Sweden.
FAU - Sorensen, Torben Lykke
AU  - Sorensen TL
AD  - Clinical Eye Research Unit, Department of Ophthalmology, Zealand University 
      Hospital, Roskilde, Denmark.
AD  - Department of Clinical Medicine, Faculty of Health Sciences, University of 
      Copenhagen.
FAU - Carosella, Edgardo D
AU  - Carosella ED
AD  - Hemato-Immunology Research Department, CEA, Hospital Saint Louis, Paris.
FAU - LeMaoult, Joel
AU  - LeMaoult J
AD  - Hemato-Immunology Research Department, CEA, Hospital Saint Louis, Paris.
FAU - Hviid, Thomas Vauvert F
AU  - Hviid TVF
AUID- ORCID: 0000-0003-0299-0151
AD  - Centre for Immune Regulation and Reproductive Immunology (CIRRI), Department of 
      Clinical Biochemistry, Zealand University Hospital, Denmark.
AD  - Department of Clinical Medicine, Faculty of Health Sciences, University of 
      Copenhagen.
FAU - Nissen, Mogens Holst
AU  - Nissen MH
AD  - Department of Immunology and Microbiology, University of Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
DEP - 20180716
PL  - England
TA  - HLA
JT  - HLA
JID - 101675570
OTO - NOTNLM
OT  - 3'UTR
OT  - 5'URR
OT  - AMD
OT  - HLA-G
OT  - age-related macular degeneration
OT  - haplotype
EDAT- 2018/07/17 06:00
MHDA- 2018/07/17 06:00
CRDT- 2018/07/17 06:00
PHST- 2018/03/15 00:00 [received]
PHST- 2018/06/14 00:00 [revised]
PHST- 2018/07/12 00:00 [accepted]
PHST- 2018/07/17 06:00 [entrez]
PHST- 2018/07/17 06:00 [pubmed]
PHST- 2018/07/17 06:00 [medline]
AID - 10.1111/tan.13340 [doi]
PST - aheadofprint
SO  - HLA. 2018 Jul 16. doi: 10.1111/tan.13340.