PMID- 30009889
OWN - NLM
STAT- MEDLINE
DCOM- 20181024
LR  - 20181024
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 120
DP  - 2018 Oct
TI  - The role of nuclear factor erythroid 2-related factor 2 in hepatoprotective 
      activity of natural products: A review.
PG  - 261-276
LID - S0278-6915(18)30469-1 [pii]
LID - 10.1016/j.fct.2018.07.024 [doi]
AB  - Internal metabolism and environmental toxicant exposure can be caused to generate 
      reactive oxygen species in human organelles which lead to oxidative stress. The 
      nuclear factor erythroid 2-related factor 2 (Nrf2), a basic leucine zipper (bZip) 
      transcription factor, controls the expression of antioxidant response element 
      (ARE)-dependent genes to regulate cellular resistance to oxidants. Nrf2 is an 
      essential factor for hepatoprotection against drugs and xenobiotics. The key role 
      of Nrf2 in hepatoprotection has been highlighted since Nrf2 knockout mice showed 
      high sensitivity to xenobiotic-induced hepatotoxicity. Some natural products 
      including polyphenols, terpenoids and alkaloids can induce Nrf2 expression as a 
      key protein in the antioxidant defense system of hepatocytes. This review 
      outlines natural product activators of Nrf2 that protect the liver from toxicity 
      induced by xenobiotics.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Iranshahy, Milad
AU  - Iranshahy M
AD  - Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical 
      Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology 
      Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Iranshahi, Mehrdad
AU  - Iranshahi M
AD  - Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical 
      Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology 
      Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Abtahi, Seyed Reza
AU  - Abtahi SR
AD  - Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
FAU - Karimi, Gholamreza
AU  - Karimi G
AD  - Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad 
      University of Medical Sciences, Mashhad, Iran; Pharmaceutical Research Center, 
      Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, 
      Mashhad, Iran. Electronic address: karimig@mums.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180720
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Biological Products)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Xenobiotics)
SB  - IM
MH  - Animals
MH  - Biological Products/*pharmacology
MH  - Humans
MH  - Liver/*drug effects
MH  - NF-E2-Related Factor 2/biosynthesis/*physiology
MH  - Xenobiotics/*toxicity
OTO - NOTNLM
OT  - Curcumin
OT  - Hepatotoxicity
OT  - Natural products
OT  - Nrf2
OT  - Sulforaphane
EDAT- 2018/07/17 06:00
MHDA- 2018/10/26 06:00
CRDT- 2018/07/17 06:00
PHST- 2018/04/30 00:00 [received]
PHST- 2018/07/11 00:00 [revised]
PHST- 2018/07/12 00:00 [accepted]
PHST- 2018/07/17 06:00 [pubmed]
PHST- 2018/10/26 06:00 [medline]
PHST- 2018/07/17 06:00 [entrez]
AID - S0278-6915(18)30469-1 [pii]
AID - 10.1016/j.fct.2018.07.024 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2018 Oct;120:261-276. doi: 10.1016/j.fct.2018.07.024. Epub 
      2018 Jul 20.